Structural Insight into TNIK Inhibition

por Kukimoto-Niino, Mutsuko, Shirouzu, Mikako, Yamada, Tesshi
Publicado 2022

Dimerization of DOCK2 Is Essential for DOCK2-Mediated Rac Activation and Lymphocyte Migration

por Terasawa, Masao, Uruno, Takehito, Mori, Sayako, Kukimoto-Niino, Mutsuko, Nishikimi, Akihiko, Sanematsu, Fumiyuki, Tanaka, Yoshihiko, Yokoyama, Shigeyuki, Fukui, Yoshinori
Publicado 2012

Cell-free synthesis of functional antibody fragments to provide a structural basis for antibody–antigen interaction

por Matsuda, Takayoshi, Ito, Takuhiro, Takemoto, Chie, Katsura, Kazushige, Ikeda, Mariko, Wakiyama, Motoaki, Kukimoto-Niino, Mutsuko, Yokoyama, Shigeyuki, Kurosawa, Yoshikazu, Shirouzu, Mikako
Publicado 2018

Structural Basis for the Inhibition of Cyclin G‐Associated Kinase by Gefitinib

por Ohbayashi, Naomi, Murayama, Kazutaka, Kato‐Murayama, Miyuki, Kukimoto‐Niino, Mutsuko, Uejima, Tamami, Matsuda, Takayoshi, Ohsawa, Noboru, Yokoyoma, Shigeyuki, Nojima, Hiroshi, Shirouzu, Mikako
Publicado 2018

Cell-permeable Carboxyl-terminal p27(Kip1) Peptide Exhibits Anti-tumor Activity by Inhibiting Pim-1 Kinase

por Morishita, Daisuke, Takami, Miho, Yoshikawa, Seiko, Katayama, Ryohei, Sato, Shigeo, Kukimoto-Niino, Mutsuko, Umehara, Takashi, Shirouzu, Mikako, Sekimizu, Kazuhisa, Yokoyama, Shigeyuki, Fujita, Naoya
Publicado 2011

A conserved PI(4,5)P2–binding domain is critical for immune regulatory function of DOCK8

por Sakurai, Tetsuya, Kukimoto-Niino, Mutsuko, Kunimura, Kazufumi, Yamane, Nana, Sakata, Daiji, Aihara, Ryosuke, Yasuda, Tomoharu, Yokoyama, Shigeyuki, Shirouzu, Mikako, Fukui, Yoshinori, Uruno, Takehito
Publicado 2021

Granzyme A Stimulates pDCs to Promote Adaptive Immunity via Induction of Type I IFN

por Shimizu, Kanako, Yamasaki, Satoru, Sakurai, Maki, Yumoto, Noriko, Ikeda, Mariko, Mishima-Tsumagari, Chiemi, Kukimoto-Niino, Mutsuko, Watanabe, Takashi, Kawamura, Masami, Shirouzu, Mikako, Fujii, Shin-ichiro
Publicado 2019

Reduced efficacy of a Src kinase inhibitor in crowded protein solution

por Kasahara, Kento, Re, Suyong, Nawrocki, Grzegorz, Oshima, Hiraku, Mishima-Tsumagari, Chiemi, Miyata-Yabuki, Yukako, Kukimoto-Niino, Mutsuko, Yu, Isseki, Shirouzu, Mikako, Feig, Michael, Sugita, Yuji
Publicado 2021

Targeting Ras-binding domain of ELMO1 by computational nanobody design

por Tam, Chunlai, Kukimoto-Niino, Mutsuko, Miyata-Yabuki, Yukako, Tsuda, Kengo, Mishima-Tsumagari, Chiemi, Ihara, Kentaro, Inoue, Mio, Yonemochi, Mayumi, Hanada, Kazuharu, Matsumoto, Takehisa, Shirouzu, Mikako, Zhang, Kam Y. J.
Publicado 2023

TNIK inhibition abrogates colorectal cancer stemness

por Masuda, Mari, Uno, Yuko, Ohbayashi, Naomi, Ohata, Hirokazu, Mimata, Ayako, Kukimoto-Niino, Mutsuko, Moriyama, Hideki, Kashimoto, Shigeki, Inoue, Tomoko, Goto, Naoko, Okamoto, Koji, Shirouzu, Mikako, Sawa, Masaaki, Yamada, Tesshi
Publicado 2016

Cryo-EM structure of the human ELMO1-DOCK5-Rac1 complex

por Kukimoto-Niino, Mutsuko, Katsura, Kazushige, Kaushik, Rahul, Ehara, Haruhiko, Yokoyama, Takeshi, Uchikubo-Kamo, Tomomi, Nakagawa, Reiko, Mishima-Tsumagari, Chiemi, Yonemochi, Mayumi, Ikeda, Mariko, Hanada, Kazuharu, Zhang, Kam Y. J., Shirouzu, Mikako
Publicado 2021

Direct homophilic interaction of LAMP2A with the two-domain architecture revealed by site-directed photo-crosslinks and steric hindrances in mammalian cells

por Terasawa, Kazue, Kato, Yuji, Ikami, Yuta, Sakamoto, Kensaku, Ohtake, Kazumasa, Kusano, Seisuke, Tomabechi, Yuri, Kukimoto-Niino, Mutsuko, Shirouzu, Mikako, Guan, Jun-Lin, Kobayashi, Toshihide, Iwata, Takanori, Watabe, Tetsuro, Yokoyama, Shigeyuki, Hara-Yokoyama, Miki
Publicado 2021

Gilteritinib overcomes lorlatinib resistance in ALK-rearranged cancer

por Mizuta, Hayato, Okada, Koutaroh, Araki, Mitsugu, Adachi, Jun, Takemoto, Ai, Kutkowska, Justyna, Maruyama, Kohei, Yanagitani, Noriko, Oh-hara, Tomoko, Watanabe, Kana, Tamai, Keiichi, Friboulet, Luc, Katayama, Kazuhiro, Ma, Biao, Sasakura, Yoko, Sagae, Yukari, Kukimoto-Niino, Mutsuko, Shirouzu, Mikako, Takagi, Satoshi, Simizu, Siro, Nishio, Makoto, Okuno, Yasushi, Fujita, Naoya, Katayama, Ryohei
Publicado 2021