DNA binding residues in the RQC domain of Werner protein are critical for its catalytic activities

por Tadokoro, Takashi, Kulikowicz, Tomasz, Dawut, Lale, Croteau, Deborah L., Bohr, Vilhelm A.
Publicado 2012

Neurologic effects of short-term treatment with a soluble epoxide hydrolase inhibitor after cardiac arrest in pediatric swine

por O’Brien, Caitlin E., Santos, Polan T., Kulikowicz, Ewa, Lee, Jennifer K., Koehler, Raymond C., Martin, Lee J.
Publicado 2020

Werner syndrome protein works as a dimer for unwinding and replication fork regression

por Shin, Soochul, Hyun, Kwangbeom, Lee, Jinwoo, Joo, Dongwon, Kulikowicz, Tomasz, Bohr, Vilhelm A, Kim, Jaehoon, Hohng, Sungchul
Publicado 2022

The helicase and ATPase activities of RECQL4 are compromised by mutations reported in three human patients

por Jensen, Martin Borch, Dunn, Christopher A., Keijzers, Guido, Kulikowicz, Tomasz, Rasmussen, Lene Juel, Croteau, Deborah L., Bohr, Vilhelm A.
Publicado 2012

Senescence induced by RECQL4 dysfunction contributes to Rothmund–Thomson syndrome features in mice

por Lu, H, Fang, E F, Sykora, P, Kulikowicz, T, Zhang, Y, Becker, K G, Croteau, D L, Bohr, V A
Publicado 2014

Oleuropein Activates Neonatal Neocortical Proteasomes, but Proteasome Gene Targeting by AAV9 Is Variable in a Clinically Relevant Piglet Model of Brain Hypoxia-Ischemia and Hypothe...

por El Demerdash, Nagat, Chen, May W., O’Brien, Caitlin E., Adams, Shawn, Kulikowicz, Ewa, Martin, Lee J., Lee, Jennifer K.
Publicado 2021

SLX4 contributes to telomere preservation and regulated processing of telomeric joint molecule intermediates

por Sarkar, Jaya, Wan, Bingbing, Yin, Jinhu, Vallabhaneni, Haritha, Horvath, Kent, Kulikowicz, Tomasz, Bohr, Vilhelm A., Zhang, Yanbin, Lei, Ming, Liu, Yie
Publicado 2015

Impaired autophagosome clearance contributes to neuronal death in a piglet model of neonatal hypoxic-ischemic encephalopathy

por Cui, Derong, Sun, Dawei, Wang, Xintao, Yi, Liye, Kulikowicz, Ewa, Reyes, Michael, Zhu, Junchao, Yang, Zeng-Jin, Jiang, Wei, Koehler, Raymond C
Publicado 2017

CDK2 phosphorylation of Werner protein (WRN) contributes to WRN’s DNA double‐strand break repair pathway choice

por Lee, Jong‐Hyuk, Shamanna, Raghavendra A., Kulikowicz, Tomasz, Borhan Fakouri, Nima, Kim, Edward W., Christiansen, Louise S., Croteau, Deborah L., Bohr, Vilhelm A.
Publicado 2021

Use of an end-tidal carbon dioxide-guided algorithm during cardiopulmonary resuscitation improves short-term survival in paediatric swine

por O'Brien, Caitlin E., Santos, Polan T., Kulikowicz, Ewa, Adams, Shawn, Lee, Jennifer K., Hunt, Elizabeth A., Koehler, Raymond C., Shaffner, Donald H.
Publicado 2021

RECQL5 cooperates with Topoisomerase II alpha in DNA decatenation and cell cycle progression

por Ramamoorthy, Mahesh, Tadokoro, Takashi, Rybanska, Ivana, Ghosh, Avik K., Wersto, Robert, May, Alfred, Kulikowicz, Tomasz, Sykora, Peter, Croteau, Deborah L., Bohr, Vilhelm A.
Publicado 2012

The Identification of a SIRT6 Activator from Brown Algae Fucus distichus

por Rahnasto-Rilla, Minna K., McLoughlin, Padraig, Kulikowicz, Tomasz, Doyle, Maire, Bohr, Vilhelm A., Lahtela-Kakkonen, Maija, Ferrucci, Luigi, Hayes, Maria, Moaddel, Ruin
Publicado 2017

Natural polyphenols as sirtuin 6 modulators

por Rahnasto-Rilla, Minna, Tyni, Jonna, Huovinen, Marjo, Jarho, Elina, Kulikowicz, Tomasz, Ravichandran, Sarangan, A. Bohr, Vilhelm, Ferrucci, Luigi, Lahtela-Kakkonen, Maija, Moaddel, Ruin
Publicado 2018

Multiple RPAs make WRN syndrome protein a superhelicase

por Lee, Mina, Shin, Soochul, Uhm, Heesoo, Hong, Heesun, Kirk, Jaewon, Hyun, Kwangbeom, Kulikowicz, Tomasz, Kim, Jaehoon, Ahn, Byungchan, Bohr, Vilhelm A, Hohng, Sungchul
Publicado 2018

The human RecQ helicases BLM and RECQL4 cooperate to preserve genome stability

por Singh, Dharmendra Kumar, Popuri, Venkateswarlu, Kulikowicz, Tomasz, Shevelev, Igor, Ghosh, Avik K., Ramamoorthy, Mahesh, Rossi, Marie L., Janscak, Pavel, Croteau, Deborah L., Bohr, Vilhelm A.
Publicado 2012

A high-throughput screen to identify novel small molecule inhibitors of the Werner Syndrome Helicase-Nuclease (WRN)

por Sommers, Joshua A., Kulikowicz, Tomasz, Croteau, Deborah L., Dexheimer, Thomas, Dorjsuren, Dorjbal, Jadhav, Ajit, Maloney, David J., Simeonov, Anton, Bohr, Vilhelm A., Brosh, Robert M.
Publicado 2019

PHOSPHORYLATION-DEPENDENT ASSOCIATION OF WRN WITH RPA IS REQUIRED FOR RECOVERY OF REPLICATION FORKS STALLED AT SECONDARY DNA STRUCTURES

por Noto, Alessandro, Valenzisi, Pasquale, Fratini, Federica, Kulikowicz, Tomasz, Sommers, Joshua A., Di Feo, Flavia, Palermo, Valentina, Semproni, Maurizio, Crescenzi, Marco, Brosh, Robert M., Franchitto, Annapaola, Pichierri, Pietro
Publicado 2023

Proteasome Biology Is Compromised in White Matter After Asphyxic Cardiac Arrest in Neonatal Piglets

por Santos, Polan T., O'Brien, Caitlin E., Chen, May W., Hopkins, C. Danielle, Adams, Shawn, Kulikowicz, Ewa, Singh, Rashmi, Koehler, Raymond C., Martin, Lee J., Lee, Jennifer K.
Publicado 2018

Pilot Study to Compare the Use of End‐Tidal Carbon Dioxide–Guided and Diastolic Blood Pressure–Guided Chest Compression Delivery in a Swine Model of Neonatal Asphyxial Cardiac Arre...

por O'Brien, Caitlin E., Reyes, Michael, Santos, Polan T., Heitmiller, Sophia E., Kulikowicz, Ewa, Kudchadkar, Sapna R., Lee, Jennifer K., Hunt, Elizabeth A., Koehler, Raymond C., Shaffner, Donald H.
Publicado 2018

Cell cycle-dependent phosphorylation regulates RECQL4 pathway choice and ubiquitination in DNA double-strand break repair

por Lu, Huiming, Shamanna, Raghavendra A., de Freitas, Jessica K., Okur, Mustafa, Khadka, Prabhat, Kulikowicz, Tomasz, Holland, Priscella P., Tian, Jane, Croteau, Deborah L., Davis, Anthony J., Bohr, Vilhelm A.
Publicado 2017