Uncovering the Role of Key Active-Site Side Chains in Catalysis: An Extended Brønsted Relationship for Substrate Deprotonation Catalyzed by Wild-Type and Variants of Triosephosphat...

por Kulkarni, Yashraj S., Amyes, Tina L., Richard, John P., Kamerlin, Shina C. L.
Publicado 2019

A sensor complements the steric gate when DNA polymerase ϵ discriminates ribonucleotides

por Parkash, Vimal, Kulkarni, Yashraj, Bylund, Göran O, Osterman, Pia, Kamerlin, Shina Caroline Lynn, Johansson, Erik
Publicado 2023

CADEE: Computer-Aided Directed Evolution of Enzymes

por Amrein, Beat Anton, Steffen-Munsberg, Fabian, Szeler, Ireneusz, Purg, Miha, Kulkarni, Yashraj, Kamerlin, Shina Caroline Lynn
Publicado 2017

Role of Ligand-Driven Conformational Changes in Enzyme Catalysis: Modeling the Reactivity of the Catalytic Cage of Triosephosphate Isomerase

por Kulkarni, Yashraj S., Liao, Qinghua, Byléhn, Fabian, Amyes, Tina L., Richard, John P., Kamerlin, Shina C. L.
Publicado 2018

Structural consequence of the most frequently recurring cancer-associated substitution in DNA polymerase ε

por Parkash, Vimal, Kulkarni, Yashraj, ter Beek, Josy, Shcherbakova, Polina V., Kamerlin, Shina Caroline Lynn, Johansson, Erik
Publicado 2019

Enzyme Architecture: Modeling the Operation of a Hydrophobic Clamp in Catalysis by Triosephosphate Isomerase

por Kulkarni, Yashraj S., Liao, Qinghua, Petrović, Dušan, Krüger, Dennis M., Strodel, Birgit, Amyes, Tina L., Richard, John P., Kamerlin, Shina C. L.
Publicado 2017