Coordinated Destruction of Cellular Messages in Translation Complexes by the Gammaherpesvirus Host Shutoff Factor and the Mammalian Exonuclease Xrn1

por Covarrubias, Sergio, Gaglia, Marta M., Kumar, G. Renuka, Wong, Wesley, Jackson, Andrew O., Glaunsinger, Britt A.
Publicado 2011

A single-component luminescent biosensor for the SARS-CoV-2 spike protein

por Ravalin, Matthew, Roh, Heegwang, Suryawanshi, Rahul, Kumar, G. Renuka, Pak, John, Ott, Melanie, Ting, Alice Y.
Publicado 2022

Novel RT-ddPCR Assays for determining the transcriptional profile of SARS-CoV-2

por Telwatte, Sushama, Kumar, Nitasha, Vallejo-Gracia, Albert, Kumar, G. Renuka, Lu, Chuanyi M., Ott, Melanie, Wong, Joseph K., Yukl, Steven A.
Publicado 2021

Novel RT-ddPCR assays for simultaneous quantification of multiple noncoding and coding regions of SARS-CoV-2 RNA

por Telwatte, Sushama, Kumar, Nitasha, Vallejo-Gracia, Albert, Kumar, G. Renuka, Lu, Chuanyi M., Ott, Melanie, Wong, Joseph K., Yukl, Steven A.
Publicado 2021

Accelerating PERx reaction enables covalent nanobodies for potent neutralization of SARS-CoV-2 and variants

por Yu, Bingchen, Li, Shanshan, Tabata, Takako, Wang, Nanxi, Cao, Li, Kumar, G. Renuka, Sun, Wei, Liu, Jun, Ott, Melanie, Wang, Lei
Publicado 2022

Global mRNA Degradation during Lytic Gammaherpesvirus Infection Contributes to Establishment of Viral Latency

por Richner, Justin M., Clyde, Karen, Pezda, Andrea C., Cheng, Benson Yee Hin, Wang, Tina, Kumar, G. Renuka, Covarrubias, Sergio, Coscoy, Laurent, Glaunsinger, Britt
Publicado 2011

Novel RT-ddPCR assays for measuring the levels of subgenomic and genomic SARS-CoV-2 transcripts

por Telwatte, Sushama, Martin, Holly Anne, Marczak, Ryan, Fozouni, Parinaz, Vallejo-Gracia, Albert, Kumar, G. Renuka, Murray, Victoria, Lee, Sulggi, Ott, Melanie, Wong, Joseph K., Yukl, Steven A.
Publicado 2022

Mercapto-pyrimidines are reversible covalent inhibitors of the papain-like protease (PLpro) and inhibit SARS-CoV-2 (SCoV-2) replication

por Bajaj, Teena, Wehri, Eddie, Suryawanshi, Rahul K., King, Elizabeth, Pardeshi, Kundan Singh, Behrouzi, Kamyar, Khodabakhshi, Zahra, Schulze-Gahmen, Ursula, Kumar, G. Renuka, Mofrad, Mohammad R. K., Nomura, Daniel K., Ott, Melanie, Schaletzky, Julia, Murthy, Niren
Publicado 2023

Tropism of SARS-CoV-2 for Developing Human Cortical Astrocytes

por Andrews, Madeline G., Mukhtar, Tanzila, Eze, Ugomma C., Simoneau, Camille R., Perez, Yonatan, Mostajo-Radji, Mohammed A., Wang, Shaohui, Velmeshev, Dmitry, Salma, Jahan, Kumar, G. Renuka, Pollen, Alex A., Crouch, Elizabeth E., Ott, Melanie, Kriegstein, Arnold R.
Publicado 2021

Transcriptomics-based drug repositioning pipeline identifies therapeutic candidates for COVID-19

por Le, Brian L., Andreoletti, Gaia, Oskotsky, Tomiko, Vallejo-Gracia, Albert, Rosales, Romel, Yu, Katharine, Kosti, Idit, Leon, Kristoffer E., Bunis, Daniel G., Li, Christine, Kumar, G. Renuka, White, Kris M., García-Sastre, Adolfo, Ott, Melanie, Sirota, Marina
Publicado 2021

Sentinel cells enable genetic detection of SARS-CoV-2 Spike protein

por Weinberg, Zara Y., Hilburger, Claire E., Kim, Matthew, Cao, Longxing, Khalid, Mir, Elmes, Sarah, Diwanji, Devan, Hernandez, Evelyn, Lopez, Jocelyne, Schaefer, Kaitlin, Smith, Amber M., Zhou, Fengbo, Kumar, G. Renuka, Ott, Melanie, Baker, David, El-Samad, Hana
Publicado 2021

Transcriptomics-based drug repositioning pipeline identifies therapeutic candidates for COVID-19

por Le, Brian L., Andreoletti, Gaia, Oskotsky, Tomiko, Vallejo-Gracia, Albert, Rosales, Romel, Yu, Katharine, Kosti, Idit, Leon, Kristoffer E., Bunis, Daniel G., Li, Christine, Kumar, G. Renuka, White, Kris M., García-Sastre, Adolfo, Ott, Melanie, Sirota, Marina
Publicado 2021

Nuclear accumulation of host transcripts during Zika Virus Infection

por Leon, Kristoffer E., Khalid, Mir M., Flynn, Ryan A., Fontaine, Krystal A., Nguyen, Thong T., Kumar, G. Renuka, Simoneau, Camille R., Tomar, Sakshi, Jimenez-Morales, David, Dunlap, Mariah, Kaye, Julia, Shah, Priya S., Finkbeiner, Steven, Krogan, Nevan J., Bertozzi, Carolyn, Carette, Jan E., Ott, Melanie
Publicado 2023

A covalent inhibitor targeting the papain-like protease from SARS-CoV-2 inhibits viral replication

por Han, Hesong, Gracia, Albert Vallejo, Røise, Joachim J., Boike, Lydia, Leon, Kristoffer, Schulze-Gahmen, Ursula, Stentzel, Michael R., Bajaj, Teena, Chen, Dake, Li, I.-Che, He, Maomao, Behrouzi, Kamyar, Khodabakhshi, Zahra, Nomura, Daniel K., Mofrad, Mohammad R. K., Kumar, G. Renuka, Ott, Melanie, Murthy, Niren
Publicado 2023

Omicron mutations enhance infectivity and reduce antibody neutralization of SARS-CoV-2 virus-like particles

por Syed, Abdullah M., Ciling, Alison, Khalid, Mir M., Sreekumar, Bharath, Chen, Pei-Yi, Kumar, G. Renuka, Silva, Ines, Milbes, Bilal, Kojima, Noah, Hess, Victoria, Shacreaw, Maria, Lopez, Lauren, Brobeck, Matthew, Turner, Fred, Spraggon, Lee, Taha, Taha Y., Tabata, Takako, Chen, Irene P., Ott, Melanie, Doudna, Jennifer A.
Publicado 2022

Omicron mutations enhance infectivity and reduce antibody neutralization of SARS-CoV-2 virus-like particles

por Syed, Abdullah M., Ciling, Alison, Taha, Taha Y., Chen, Irene P., Khalid, Mir M., Sreekumar, Bharath, Chen, Pei-Yi, Kumar, G. Renuka, Suryawanshi, Rahul, Silva, Ines, Milbes, Bilal, Kojima, Noah, Hess, Victoria, Shacreaw, Maria, Lopez, Lauren, Brobeck, Matthew, Turner, Fred, Spraggon, Lee, Tabata, Takako, Ott, Melanie, Doudna, Jennifer A.
Publicado 2022

Upper airway gene expression differentiates COVID-19 from other acute respiratory illnesses and reveals suppression of innate immune responses by SARS-CoV-2

por Mick, Eran, Kamm, Jack, Pisco, Angela Oliveira, Ratnasiri, Kalani, Babik, Jennifer M., Calfee, Carolyn S., Castañeda, Gloria, DeRisi, Joseph L., Detweiler, Angela M., Hao, Samantha, Kangelaris, Kirsten N., Kumar, G. Renuka, Li, Lucy M., Mann, Sabrina A., Neff, Norma, Prasad, Priya A., Serpa, Paula Hayakawa, Shah, Sachin J., Spottiswoode, Natasha, Tan, Michelle, Christenson, Stephanie A., Kistler, Amy, Langelier, Charles
Publicado 2020

Neutralizing immunity in vaccine breakthrough infections from the SARS-CoV-2 Omicron and Delta variants

por Servellita, Venice, Syed, Abdullah M., Morris, Mary Kate, Brazer, Noah, Saldhi, Prachi, Garcia-Knight, Miguel, Sreekumar, Bharath, Khalid, Mir M., Ciling, Alison, Chen, Pei-Yi, Kumar, G. Renuka, Gliwa, Amelia S., Nguyen, Jenny, Sotomayor-Gonzalez, Alicia, Zhang, Yueyuan, Frias, Edwin, Prostko, John, Hackett, John, Andino, Raul, Wadford, Debra A., Hanson, Carl, Doudna, Jennifer, Ott, Melanie, Chiu, Charles Y.
Publicado 2022

Upper airway gene expression reveals suppressed immune responses to SARS-CoV-2 compared with other respiratory viruses

por Mick, Eran, Kamm, Jack, Pisco, Angela Oliveira, Ratnasiri, Kalani, Babik, Jennifer M., Castañeda, Gloria, DeRisi, Joseph L., Detweiler, Angela M., Hao, Samantha L., Kangelaris, Kirsten N., Kumar, G. Renuka, Li, Lucy M., Mann, Sabrina A., Neff, Norma, Prasad, Priya A., Serpa, Paula Hayakawa, Shah, Sachin J., Spottiswoode, Natasha, Tan, Michelle, Calfee, Carolyn S., Christenson, Stephanie A., Kistler, Amy, Langelier, Charles
Publicado 2020

Tropism of SARS-CoV-2 for human cortical astrocytes

por Andrews, Madeline G., Mukhtar, Tanzila, Eze, Ugomma C., Simoneau, Camille R., Ross, Jayden, Parikshak, Neelroop, Wang, Shaohui, Zhou, Li, Koontz, Mark, Velmeshev, Dmitry, Siebert, Clara-Vita, Gemenes, Kaila M., Tabata, Takako, Perez, Yonatan, Wang, Li, Mostajo-Radji, Mohammed A., de Majo, Martina, Donohue, Kevin C., Shin, David, Salma, Jahan, Pollen, Alex A., Nowakowski, Tomasz J., Ullian, Erik, Kumar, G. Renuka, Winkler, Ethan A., Crouch, Elizabeth E., Ott, Melanie, Kriegstein, Arnold R.
Publicado 2022