The relevance of contact-independent cell-to-cell transfer of TDP-43 and SOD1 in amyotrophic lateral sclerosis

por Hanspal, Maya A., Dobson, Christopher M., Yerbury, Justin J., Kumita, Janet R.
Publicado 2017

Alpha-2-Macroglobulin Is Acutely Sensitive to Freezing and Lyophilization: Implications for Structural and Functional Studies

por Wyatt, Amy R., Kumita, Janet R., Farrawell, Natalie E., Dobson, Christopher M., Wilson, Mark R.
Publicado 2015

Solvent exposure of Tyr10 as a probe of structural differences between monomeric and aggregated forms of the amyloid-β peptide

por Aran Terol, Pablo, Kumita, Janet R., Hook, Sharon C., Dobson, Christopher M., Esbjörner, Elin K.
Publicado 2015

Hypochlorite-induced oxidation promotes aggregation and reduces toxicity of amyloid beta 1-42

por Mañucat-Tan, Noralyn B., Chowdhury, Ashfaq, Cataldi, Rodrigo, Abdullah, Rafaa Zeineddine, Kumita, Janet R., Wyatt, Amy R.
Publicado 2023

Serum amyloid P component promotes formation of distinct aggregated lysozyme morphologies and reduces toxicity in Drosophila flies expressing F57I lysozyme

por Bergkvist, Liza, Richards, Daniel R., Bernardo-Gancedo, Ana, Kumita, Janet R., Nilsson, Peter R., Brorsson, Ann-Christin
Publicado 2020

Exogenous misfolded protein oligomers can cross the intestinal barrier and cause a disease phenotype in C. elegans

por Perni, Michele, Mannini, Benedetta, Xu, Catherine K., Kumita, Janet R., Dobson, Christopher M., Chiti, Fabrizio, Vendruscolo, Michele
Publicado 2021

Mapping pathogenic processes contributing to neurodegeneration in Drosophila models of Alzheimer's disease

por Bergkvist, Liza, Du, Zhen, Elovsson, Greta, Appelqvist, Hanna, Itzhaki, Laura S., Kumita, Janet R., Kågedal, Katarina, Brorsson, Ann‐Christin
Publicado 2020

Probing the unfolded protein response in long-lived naked mole-rats

por Du, Zhen, Chakrabarti, Sampurna, Kulaberoglu, Yavuz, Smith, Ewan St John, Dobson, Christopher M., Itzhaki, Laura S., Kumita, Janet R.
Publicado 2020

Structural Characterization of Covalently Stabilized Human Cystatin C Oligomers

por Chrabąszczewska, Magdalena, Sieradzan, Adam K., Rodziewicz-Motowidło, Sylwia, Grubb, Anders, Dobson, Christopher M., Kumita, Janet R., Kozak, Maciej
Publicado 2020

Analysis of the Native Structure, Stability and Aggregation of Biotinylated Human Lysozyme

por Ahn, Minkoo, De Genst, Erwin, Kaminski Schierle, Gabriele S., Erdelyi, Miklos, Kaminski, Clemens F., Dobson, Christopher M., Kumita, Janet R.
Publicado 2012

Protease-activated alpha-2-macroglobulin can inhibit amyloid formation via two distinct mechanisms

por Wyatt, Amy R., Constantinescu, Patrick, Ecroyd, Heath, Dobson, Christopher M., Wilson, Mark R., Kumita, Janet R., Yerbury, Justin J.
Publicado 2013

Amyloid-like Fibrils from an α-Helical Transmembrane Protein

por Stroobants, Karen, Kumita, Janet R., Harris, Nicola J., Chirgadze, Dimitri Y., Dobson, Christopher M., Booth, Paula J., Vendruscolo, Michele
Publicado 2017

Native-State Stability Determines the Extent of Degradation Relative to Secretion of Protein Variants from Pichia pastoris

por Whyteside, Graham, Alcocer, Marcos J. C., Kumita, Janet R., Dobson, Christopher M., Lazarou, Maria, Pleass, Richard J., Archer, David B.
Publicado 2011

Structure and Dynamics of the Integrin LFA-1 I-Domain in the Inactive State Underlie its Inside-Out/Outside-In Signaling and Allosteric Mechanisms

por Kukic, Predrag, Alvin Leung, Hoi Tik, Bemporad, Francesco, Aprile, Francesco A., Kumita, Janet R., De Simone, Alfonso, Camilloni, Carlo, Vendruscolo, Michele
Publicado 2015

Application of Lysine-specific Labeling to Detect Transient Interactions Present During Human Lysozyme Amyloid Fibril Formation

por Ahn, Minkoo, Waudby, Christopher A., Bernardo-Gancedo, Ana, De Genst, Erwin, Dhulesia, Anne, Salvatella, Xavier, Christodoulou, John, Dobson, Christopher M., Kumita, Janet R.
Publicado 2017

Disulfide Bonds Reduce the Toxicity of the Amyloid Fibrils Formed by an Extracellular Protein**

por Mossuto, Maria F, Bolognesi, Benedetta, Guixer, Bernat, Dhulesia, Anne, Agostini, Federico, Kumita, Janet R, Tartaglia, Gian G, Dumoulin, Mireille, Dobson, Christopher M, Salvatella, Xavier
Publicado 2011

Influence of Point Mutations on PR65 Conformational Adaptability: Insights from Nanoaperture Optical Tweezer Experiments and Molecular Simulations

por Bahar, Ivet, Banerjee, Anupam, Mathew, Samuel, Naqvi, Mohsin, Yilmaz, Sema, Zachoropoulou, Maria, Doruker, Pemra, Kumita, Janet, Yang, Shang-Hua, Gur, Mert, Itzhaki, Laura, Gordon, Reuven
Publicado 2023

The Non-Core Regions of Human Lysozyme Amyloid Fibrils Influence Cytotoxicity

por Mossuto, Maria F., Dhulesia, Anne, Devlin, Glyn, Frare, Erica, Kumita, Janet R., de Laureto, Patrizia Polverino, Dumoulin, Mireille, Fontana, Angelo, Dobson, Christopher M., Salvatella, Xavier
Publicado 2010

Local Cooperativity in an Amyloidogenic State of Human Lysozyme Observed at Atomic Resolution

por Dhulesia, Anne, Cremades, Nunilo, Kumita, Janet R., Hsu, Shang-Te Danny, Mossuto, Maria F., Dumoulin, Mireille, Nietlispach, Daniel, Akke, Mikael, Salvatella, Xavier, Dobson, Christopher M.
Publicado 2010

Disease-related amyloidogenic variants of human lysozyme trigger the unfolded protein response and disturb eye development in Drosophila melanogaster

por Kumita, Janet R., Helmfors, Linda, Williams, Jocy, Luheshi, Leila M., Menzer, Linda, Dumoulin, Mireille, Lomas, David A., Crowther, Damian C., Dobson, Christopher M., Brorsson, Ann-Christin
Publicado 2012