Comparing molecular and computational approaches for detecting viral integration of AAV gene therapy constructs

por Oziolor, Elias M., Kumpf, Steven W., Qian, Jessie, Gosink, Mark, Sheehan, Mark, Rubitski, David M., Newman, Leah, Whiteley, Laurence O., Lanz, Thomas A.
Publicado 2023

Biodistribution and Tolerability of AAV-PHP.B-CBh-SMN1 in Wistar Han Rats and Cynomolgus Macaques Reveal Different Toxicologic Profiles

por Palazzi, Xavier, Pardo, Ingrid D., Sirivelu, Madhu P., Newman, Leah, Kumpf, Steven W., Qian, Jessie, Franks, Tania, Lopes, Sarah, Liu, June, Monarski, Laura, Casinghino, Sandra, Ritenour, Casey, Ritenour, Hayley, Dubois, Christopher, Olson, Jennifer, Graves, John, Alexander, Kristin E., Coskran, Timothy, Lanz, Thomas A., Brady, Joseph, McCarty, Douglas, Suryanarayan, Somanathan, Whiteley, Laurence O.
Publicado 2022

Use of the dTAG system in vivo to degrade CDK2 and CDK5 in adult mice and explore potential safety liabilities

por Yenerall, Paul, Sung, Tae, Palyada, Kiran, Qian, Jessie, Arat, Seda, Kumpf, Steven W, Wang, Shih-Wen, Biddle, Kathleen, Esparza, Carlos, Chang, Stephanie, Scott, Wesley, Collette, Walter, Winrow, Taylor-Symon, Affolter, Tim, Shirai, Norimitsu, Thibault, Stephane, Wang, Julia, Liu, Ling, Bauchmann, Mary, Frey, Jessica, Steyn, Stefanus, Sacaan, Aida, Vitsky, Allison, Ahn, Youngwook, Paul, Tom, Lum, Lawrence, Oyer, Jon, Yang, Amy, Hu, Wenyue
Publicado 2023