Comprehensive transcriptome analysis of fluid shear stress altered gene expression in renal epithelial cells

por Kunnen, Steven J., Malas, Tareq B., Semeins, Cornelis M., Bakker, Astrid D., Peters, Dorien J. M.
Publicado 2017

An ensemble learning approach for modeling the systems biology of drug-induced injury

por Aguirre-Plans, Joaquim, Piñero, Janet, Souza, Terezinha, Callegaro, Giulia, Kunnen, Steven J., Sanz, Ferran, Fernandez-Fuentes, Narcis, Furlong, Laura I., Guney, Emre, Oliva, Baldo
Publicado 2021

Fluid shear stress-induced TGF-β/ALK5 signaling in renal epithelial cells is modulated by MEK1/2

por Kunnen, Steven J., Leonhard, Wouter N., Semeins, Cor, Hawinkels, Lukas J. A. C., Poelma, Christian, ten Dijke, Peter, Bakker, Astrid, Hierck, Beerend P., Peters, Dorien J. M.
Publicado 2017

High-Throughput Phenotypic Screening of Kinase Inhibitors to Identify Drug Targets for Polycystic Kidney Disease

por Booij, Tijmen H., Bange, Hester, Leonhard, Wouter N., Yan, Kuan, Fokkelman, Michiel, Kunnen, Steven J., Dauwerse, Johannes G., Qin, Yu, van de Water, Bob, van Westen, Gerard J. P., Peters, Dorien J. M., Price, Leo S.
Publicado 2017

Identifying multiscale translational safety biomarkers using a network-based systems approach

por Callegaro, Giulia, Schimming, Johannes P., Piñero González, Janet, Kunnen, Steven J., Wijaya, Lukas, Trairatphisan, Panuwat, van den Berk, Linda, Beetsma, Kim, Furlong, Laura I., Sutherland, Jeffrey J., Mollon, Jennifer, Stevens, James L., van de Water, Bob
Publicado 2023

The human hepatocyte TXG-MAPr: gene co-expression network modules to support mechanism-based risk assessment

por Callegaro, Giulia, Kunnen, Steven J., Trairatphisan, Panuwat, Grosdidier, Solène, Niemeijer, Marije, den Hollander, Wouter, Guney, Emre, Piñero Gonzalez, Janet, Furlong, Laura, Webster, Yue W., Saez-Rodriguez, Julio, Sutherland, Jeffrey J., Mollon, Jennifer, Stevens, James L., van de Water, Bob
Publicado 2021

A systems approach reveals species differences in hepatic stress response capacity

por Russomanno, Giusy, Sison-Young, Rowena, Livoti, Lucia A, Coghlan, Hannah, Jenkins, Rosalind E, Kunnen, Steven J, Fisher, Ciarán P, Reddyhoff, Dennis, Gardner, Iain, Rehman, Adeeb H, Fenwick, Stephen W, Jones, Andrew R, Vermeil De Conchard, Guy, Simonin, Gilles, Bertheux, Helene, Weaver, Richard J, Johnson, Robert L, Liguori, Michael J, Clausznitzer, Diana, Stevens, James L, Goldring, Christopher E, Copple, Ian M
Publicado 2023