Systematic profiling of temperature- and retinal-sensitive rhodopsin variants by deep mutational scanning

por McKee, Andrew G., Kuntz, Charles P., Ortega, Joseph T., Woods, Hope, Most, Victoria, Roushar, Francis J., Meiler, Jens, Jastrzebska, Beata, Schlebach, Jonathan P.
Publicado 2021

Coordination of -1 programmed ribosomal frameshifting by transcript and nascent chain features revealed by deep mutational scanning

por Carmody, Patrick J, Zimmer, Matthew H, Kuntz, Charles P, Harrington, Haley R, Duckworth, Kate E, Penn, Wesley D, Mukhopadhyay, Suchetana, Miller, Thomas F, Schlebach, Jonathan P
Publicado 2021

Molecular basis for the evolved instability of a human G-protein coupled receptor

por Chamness, Laura M., Zelt, Nathan B., Harrington, Haley R., Kuntz, Charles P., Bender, Brian J., Penn, Wesley D., Ziarek, Joshua J., Meiler, Jens, Schlebach, Jonathan P.
Publicado 2021

Divergent Pairwise Epistasis in the Context of Unstable Membrane Protein Variants

por Chamness, Laura M., Kuntz, Charles P., McKee, Andrew G., Penn, Wesley D., Hemmerich, Christopher M., Rusch, Douglas B., Woods, Hope, Dyotima, Meiler, Jens, Schlebach, Jonathan P.
Publicado 2023

Molecular basis for variations in the sensitivity of pathogenic rhodopsin variants to 9-cis-retinal

por Roushar, Francis J., McKee, Andrew G., Kuntz, Charles P., Ortega, Joseph T., Penn, Wesley D., Woods, Hope, Chamness, Laura M., Most, Victoria, Meiler, Jens, Jastrzebska, Beata, Schlebach, Jonathan P.
Publicado 2022

Probing biophysical sequence constraints within the transmembrane domains of rhodopsin by deep mutational scanning

por Penn, Wesley D., McKee, Andrew G., Kuntz, Charles P., Woods, Hope, Nash, Veronica, Gruenhagen, Timothy C., Roushar, Francis J., Chandak, Mahesh, Hemmerich, Chris, Rusch, Douglas B., Meiler, Jens, Schlebach, Jonathan P.
Publicado 2020