Adlay (薏苡 yì yĭ; “soft-shelled job's tears”; the seeds of Coix lachryma-jobi L. var. ma-yuen Stapf) is a Potential Cancer Chemopreventive Agent toward Multistage Carcinogenesis Pro...

por Kuo, Ching-Chuan, Chen, Huang-Hui, Chiang, Wenchang
Publicado 2012

Novel microtubule inhibitor MPT0B098 inhibits hypoxia-induced epithelial-to-mesenchymal transition in head and neck squamous cell carcinoma

por Tsai, I-Ting, Kuo, Ching-Chuan, Liou, Jing-Ping, Chang, Jang-Yang
Publicado 2018

Desferal regulates hCtr1 and transferrin receptor expression through Sp1 and exhibits synergistic cytotoxicity with platinum drugs in oxaliplatin-resistant human cervical cancer ce...

por Chen, Szu-Jung, Kuo, Ching-Chuan, Pan, Hsin-Yi, Tsou, Tsui-Chun, Yeh, Szu-Ching, Chang, Jang-Yang
Publicado 2016

Pilot Study: Nutritional and Preclinical Safety Investigation of Fermented Hispidin-Enriched Sanghuangporus sanghuang Mycelia: A Promising Functional Food Material to Improve Sleep

por Li, I-Chen, Chang, Fang-Chia, Kuo, Ching-Chuan, Chu, Hsin-Tung, Li, Tsung-Ju, Chen, Chin-Chu
Publicado 2022

How to deal with frenemy NRF2: Targeting NRF2 for chemoprevention and cancer therapy

por Tang, Ya-Chu, Chuang, Yung-Jen, Chang, Hsin-Huei, Juang, Shin-Hun, Yen, Gow-Chin, Chang, Jang-Yang, Kuo, Ching-Chuan
Publicado 2023

Survivin counteracts the therapeutic effect of microtubule de-stabilizers by stabilizing tubulin polymers

por Cheung, Chun Hei Antonio, Chen, Huang-Hui, Kuo, Ching-Chuan, Chang, Chi-Yen, Coumar, Mohane S, Hsieh, Hsing-Pang, Chang, Jang-Yang
Publicado 2009

A Novel Synthetic Microtubule Inhibitor, MPT0B214 Exhibits Antitumor Activity in Human Tumor Cells through Mitochondria-Dependent Intrinsic Pathway

por Chiang, Nai-Jung, Lin, Ching-I, Liou, Jing-Ping, Kuo, Ching-Chuan, Chang, Chi-Yen, Chen, Li-Tzong, Chang, Jang-Yang
Publicado 2013

Synthesis and Biological Evaluation of 4-Aroyl-6,7,8-Trimethoxyquinolines as a Novel Class of Anticancer Agents

por Hsieh, Cheng-Chih, Lee, Hsueh-Yun, Nien, Chih-Ying, Kuo, Ching-Chuan, Chang, Chi-Yen, Chang, Jang-Yang, Liou, Jing-Ping
Publicado 2011

A novel NRF2/ARE inhibitor gossypol induces cytotoxicity and sensitizes chemotherapy responses in chemo-refractory cancer cells

por Tang, Ya-Chu, Chang, Hsin-Huei, Chen, Huang-Hui, Yao, Jau-Ying, Chen, Yu-Tsen, Chuang, Yung-Jen, Chang, Jang-Yang, Kuo, Ching-Chuan
Publicado 2021

Melatonin promotes neuroblastoma cell differentiation by activating hyaluronan synthase 3‐induced mitophagy

por Lee, Wen‐Jui, Chen, Li‐Ching, Lin, Juo‐Han, Cheng, Tzu‐Chun, Kuo, Ching‐Chuan, Wu, Chih‐Hsiung, Chang, Hui‐Wen, Tu, Shih‐Hsin, Ho, Yuan‐Soon
Publicado 2019

MiR-30a and miR-379 modulate retinoic acid pathway by targeting DNA methyltransferase 3B in oral cancer

por Shiah, Shine-Gwo, Hsiao, Jenn-Ren, Chang, Hsiao-Ju, Hsu, Yuan-Ming, Wu, Guan-Hsun, Peng, Hsuan-Yu, Chou, Sung-Tau, Kuo, Ching-Chuan, Chang, Jang-Yang
Publicado 2020

MPT0B098, a Microtubule Inhibitor, Suppresses JAK2/STAT3 Signaling Pathway through Modulation of SOCS3 Stability in Oral Squamous Cell Carcinoma

por Peng, Hsuan-Yu, Cheng, Yun-Ching, Hsu, Yuan-Ming, Wu, Guan-Hsun, Kuo, Ching-Chuan, Liou, Jing-Ping, Chang, Jang-Yang, Jin, Shiow-Lian Catherine, Shiah, Shine-Gwo
Publicado 2016

Synthesis and Structure–Activity Relationship of Salvinal Derivatives as Potent Microtubule Inhibitors

por Chang, Chi-I, Hsieh, Cheng-Chih, Wein, Yung-Shung, Kuo, Ching-Chuan, Chang, Chi-Yen, Lung, Jrhau, Cherng, Jong-Yuh, Chu, Po-Chen, Chang, Jang-Yang, Kuo, Yueh-Hsiung
Publicado 2023

Xanthine Derivatives Reveal an Allosteric Binding Site in Methylenetetrahydrofolate Dehydrogenase 2 (MTHFD2)

por Lee, Lung-Chun, Peng, Yi-Hui, Chang, Hsin-Huei, Hsu, Tsu, Lu, Cheng-Tai, Huang, Chih-Hsiang, Hsueh, Ching-Cheng, Kung, Fang-Chun, Kuo, Ching-Chuan, Jiaang, Weir-Torn, Wu, Su-Ying
Publicado 2021

Tea polyphenol epigallocatechin-3-gallate inhibits cell proliferation in a patient-derived triple-negative breast cancer xenograft mouse model via inhibition of proline-dehydrogena...

por Lee, Wen-Jui, Cheng, Tzu-Chun, Yen, Yun, Fang, Chia-Lang, Liao, You-Cheng, Kuo, Ching-Chuan, Tu, Shih-Hsin, Lin, Li-Cheng, Chang, Hui-Wen, Chen, Li-Ching, Ho, Yuan-Soon
Publicado 2021

Surface α-Enolase Promotes Extracellular Matrix Degradation and Tumor Metastasis and Represents a New Therapeutic Target

por Hsiao, Kuan-Chung, Shih, Neng-Yao, Fang, Hsun-Lang, Huang, Tze-Sing, Kuo, Ching-Chuan, Chu, Pei-Yi, Hung, Yi-Mei, Chou, Shao-Wen, Yang, Yi-Yuan, Chang, Gee-Chen, Liu, Ko-Jiunn
Publicado 2013

ERK Activation Modulates Cancer Stemness and Motility of a Novel Mouse Oral Squamous Cell Carcinoma Cell Line

por Chen, Yu-Lin, Liu, Ko-Jiunn, Jang, Chuan-Wei, Hsu, Chia-Chun, Yen, Yi-Chen, Liu, Yi-Ling, Chuang, Tsung-Hsien, Wang, Ssu-Han, Fu, Yu-Ke, Kuo, Ching-Chuan, Chen, Ya-Wen
Publicado 2019

Type-3 Hyaluronan Synthase Attenuates Tumor Cells Invasion in Human Mammary Parenchymal Tissues

por Lee, Wen-Jui, Tu, Shih-Hsin, Cheng, Tzu-Chun, Lin, Juo-Han, Sheu, Ming-Thau, Kuo, Ching-Chuan, Changou, Chun A., Wu, Chih-Hsiung, Chang, Hui-Wen, Chang, Hang-Lung, Chen, Li-Ching, Ho, Yuan-Soon
Publicado 2021

c-MYC-directed NRF2 drives malignant progression of head and neck cancer via glucose-6-phosphate dehydrogenase and transketolase activation

por Tang, Ya-Chu, Hsiao, Jenn-Ren, Jiang, Shih-Sheng, Chang, Jang-Yang, Chu, Pei-Yi, Liu, Ko-Jiunn, Fang, Hsun-Lang, Lin, Li-Mei, Chen, Huang-Hui, Huang, Yen-Wen, Chen, Yu-Tsen, Tsai, Fang-Yu, Lin, Su-Fang, Chuang, Yung-Jen, Kuo, Ching-Chuan
Publicado 2021

Discovery of BPR1K871, a quinazoline based, multi-kinase inhibitor for the treatment of AML and solid tumors: Rational design, synthesis, in vitro and in vivo evaluation

por Hsu, Yung Chang, Coumar, Mohane Selvaraj, Wang, Wen-Chieh, Shiao, Hui-Yi, Ke, Yi-Yu, Lin, Wen-Hsing, Kuo, Ching-Chuan, Chang, Chun-Wei, Kuo, Fu-Ming, Chen, Pei-Yi, Wang, Sing-Yi, Li, An-Siou, Chen, Chun-Hwa, Kuo, Po-Chu, Chen, Ching-Ping, Wu, Ming-Hsine, Huang, Chen-Lung, Yen, Kuei-Jung, Chang, Yun-I, Hsu, John T.-A., Chen, Chiung-Tong, Yeh, Teng-Kuang, Song, Jen-Shin
Publicado 2016