Novel asymmetrically engineered antibody Fc variant with superior FcγR binding affinity and specificity compared with afucosylated Fc variant

por Mimoto, Futa, Igawa, Tomoyuki, Kuramochi, Taichi, Katada, Hitoshi, Kadono, Shojiro, Kamikawa, Takayuki, Shida-Kawazoe, Meiri, Hattori, Kunihiro
Publicado 2013

Antibody engineering to generate SKY59, a long-acting anti-C5 recycling antibody

por Sampei, Zenjiro, Haraya, Kenta, Tachibana, Tatsuhiko, Fukuzawa, Taku, Shida-Kawazoe, Meiri, Gan, Siok Wan, Shimizu, Yuichiro, Ruike, Yoshinao, Feng, Shu, Kuramochi, Taichi, Muraoka, Masaru, Kitazawa, Takehisa, Kawabe, Yoshiki, Igawa, Tomoyuki, Hattori, Kunihiro, Nezu, Junichi
Publicado 2018

Elimination of plasma soluble antigen in cynomolgus monkeys by combining pH-dependent antigen binding and novel Fc engineering

por Hori, Yuji, Ohmine, Ken, Katada, Hitoshi, Noguchi, Yuki, Sato, Kazuki, Nambu, Takeru, Adeline, Lam Runyi, Wan, Gan Siok, Haraya, Kenta, Ozeki, Kazuhisa, Nanami, Masahiko, Tachibana, Tatsuhiko, Sampei, Zenjiro, Kuramochi, Taichi, Nezu, Junichi, Hattori, Kunihiro, Igawa, Tomoyuki
Publicado 2022

Efficient production of bispecific antibody by FAST-Ig(TM) and its application to NXT007 for the treatment of hemophilia A

por Koga, Hikaru, Yamano, Takashi, Betancur, Juan, Nagatomo, Satoko, Ikeda, Yousuke, Yamaguchi, Kazuki, Nabuchi, Yoshiaki, Sato, Kazuki, Teranishi-Ikawa, Yuri, Sato, Motohiko, Hirayama, Hiroyuki, Hayasaka, Akira, Torizawa, Takuya, Haraya, Kenta, Sampei, Zenjiro, Shiraiwa, Hirotake, Kitazawa, Takehisa, Igawa, Tomoyuki, Kuramochi, Taichi
Publicado 2023

Comprehensive engineering of a therapeutic neutralizing antibody targeting SARS-CoV-2 spike protein to neutralize escape variants

por Kuramochi, Taichi, Gan, Siok Wan, Ho, Adrian W.S., Wang, Bei, Kageji, Nagisa, Nambu, Takeru, Iida, Sayaka, Okuda-Miura, Momoko, Chia, Wei Shan, Yeo, Chiew Ying, Chen, Dan, Lee, Wen-Hsin, Ngoh, Eve Zi Xian, Mohd Salleh, Siti Nazihah, Wang, Cheng-I, Igawa, Tomoyuki, Shimada, Hideaki
Publicado 2022

Novel myostatin-specific antibody enhances muscle strength in muscle disease models

por Muramatsu, Hiroyasu, Kuramochi, Taichi, Katada, Hitoshi, Ueyama, Atsunori, Ruike, Yoshinao, Ohmine, Ken, Shida-Kawazoe, Meiri, Miyano-Nishizawa, Rie, Shimizu, Yuichiro, Okuda, Momoko, Hori, Yuji, Hayashi, Madoka, Haraya, Kenta, Ban, Nobuhiro, Nonaka, Tatsuya, Honda, Masaki, Kitamura, Hidetomo, Hattori, Kunihiro, Kitazawa, Takehisa, Igawa, Tomoyuki, Kawabe, Yoshiki, Nezu, Junichi
Publicado 2021