Mechanisms of action of therapeutic amyloidogenic hexapeptides in amelioration of inflammatory brain disease

por Kurnellas, Michael P., Schartner, Jill M., Fathman, C. Garrison, Jagger, Ann, Steinman, Lawrence, Rothbard, Jonathan B.
Publicado 2014

An amyloidogenic hexapeptide derived from amylin attenuates inflammation and acute lung injury in murine sepsis

por Mahapatra, Sidharth, Ying, Lihua, Ho, Peggy Pui-Kay, Kurnellas, Michael, Rothbard, Jonathan, Steinman, Lawrence, Cornfield, David N.
Publicado 2018

Latozinemab, a novel progranulin-elevating therapy for frontotemporal dementia

por Kurnellas, Michael, Mitra, Ananya, Schwabe, Tina, Paul, Robert, Arrant, Andrew E., Roberson, Erik D., Ward, Michael, Yeh, Felix, Long, Hua, Rosenthal, Arnon
Publicado 2023

AAV-GRN partially corrects motor deficits and ALS/FTLD-related pathology in Tmem106b(−/−)Grn(−/−) mice

por Feng, Tuancheng, Minevich, Gregory, Liu, Pengan, Qin, Henry Xin, Wozniak, Glenn, Pham, Jenny, Pham, Khanh, Korgaonkar, Akshata, Kurnellas, Michael, Defranoux, Nadine A., Long, Hua, Mitra, Ananya, Hu, Fenghua
Publicado 2023

Granulin loss of function in human mature brain organoids implicates astrocytes in TDP-43 pathology

por de Majo, Martina, Koontz, Mark, Marsan, Elise, Salinas, Nir, Ramsey, Arren, Kuo, Yien-Ming, Seo, Kyounghee, Li, Huinan, Dräger, Nina, Leng, Kun, Gonzales, Santiago L., Kurnellas, Michael, Miyaoka, Yuichiro, Klim, Joseph R., Kampmann, Martin, Ward, Michael E., Huang, Eric J., Ullian, Erik M.
Publicado 2023

Roadmap for C9ORF72 in Frontotemporal Dementia and Amyotrophic Lateral Sclerosis: Report on the C9ORF72 FTD/ALS Summit

por Sattler, Rita, Traynor, Bryan J., Robertson, Janice, Van Den Bosch, Ludo, Barmada, Sami J., Svendsen, Clive N., Disney, Matthew D., Gendron, Tania F., Wong, Philip C., Turner, Martin R., Boxer, Adam, Babu, Suma, Benatar, Michael, Kurnellas, Michael, Rohrer, Jonathan D., Donnelly, Christopher J., Bustos, Lynette M., Van Keuren-Jensen, Kendall, Dacks, Penny A., Sabbagh, Marwan N.
Publicado 2023