Viral proteases: Structure, mechanism and inhibition

por Zephyr, Jacqueto, Kurt Yilmaz, Nese, Schiffer, Celia A.
Publicado 2021

Interdependence of Inhibitor Recognition in HIV-1 Protease

por Paulsen, Janet L., Leidner, Florian, Ragland, Debra A., Kurt Yilmaz, Nese, Schiffer, Celia A.
Publicado 2017

Drug Resistance Mutations Alter Dynamics of Inhibitor-Bound HIV-1 Protease

por Cai, Yufeng, Myint, Wazo, Paulsen, Janet L., Schiffer, Celia A., Ishima, Rieko, Kurt Yilmaz, Nese
Publicado 2014

Structural basis of substrate specificity in human cytidine deaminase family APOBEC3s

por Hou, Shurong, Lee, Jeong Min, Myint, Wazo, Matsuo, Hiroshi, Kurt Yilmaz, Nese, Schiffer, Celia A.
Publicado 2021

Mechanism for APOBEC3G catalytic exclusion of RNA and non-substrate DNA

por Solomon, William C, Myint, Wazo, Hou, Shurong, Kanai, Tapan, Tripathi, Rashmi, Kurt Yilmaz, Nese, Schiffer, Celia A, Matsuo, Hiroshi
Publicado 2019

Substrate sequence selectivity of APOBEC3A implicates intra-DNA interactions

por Silvas, Tania V., Hou, Shurong, Myint, Wazo, Nalivaika, Ellen, Somasundaran, Mohan, Kelch, Brian A., Matsuo, Hiroshi, Kurt Yilmaz, Nese, Schiffer, Celia A.
Publicado 2018

T cell epitope engineering: an avian H7N9 influenza vaccine strategy for pandemic preparedness and response

por Moise, Leonard, M. Biron, Bethany, Boyle, Christine M., Kurt Yilmaz, Nese, Jang, Hyesun, Schiffer, Celia, M. Ross, Ted, Martin, William D., De Groot, Anne S.
Publicado 2018

Crystal Structures of Inhibitor-Bound Main Protease from Delta- and Gamma-Coronaviruses

por Zvornicanin, Sarah N., Shaqra, Ala M., Huang, Qiuyu J., Ornelas, Elizabeth, Moghe, Mallika, Knapp, Mark, Moquin, Stephanie, Dovala, Dustin, Schiffer, Celia A., Kurt Yilmaz, Nese
Publicado 2023

Crystal Structure of SARS-CoV-2 Main Protease in Complex with the Non-Covalent Inhibitor ML188

por Lockbaum, Gordon J., Reyes, Archie C., Lee, Jeong Min, Tilvawala, Ronak, Nalivaika, Ellen A., Ali, Akbar, Kurt Yilmaz, Nese, Thompson, Paul R., Schiffer, Celia A.
Publicado 2021

Drug Resistance Conferred by Mutations Outside the Active Site through Alterations in the Dynamic and Structural Ensemble of HIV-1 Protease

por Ragland, Debra A., Nalivaika, Ellen A., Nalam, Madhavi N. L., Prachanronarong, Kristina L., Cao, Hong, Bandaranayake, Rajintha M., Cai, Yufeng, Kurt-Yilmaz, Nese, Schiffer, Celia A.
Publicado 2014

Avoiding Drug Resistance by Substrate Envelope-Guided Design: Toward Potent and Robust HCV NS3/4A Protease Inhibitors

por Matthew, Ashley N., Zephyr, Jacqueto, Nageswara Rao, Desaboini, Henes, Mina, Kamran, Wasih, Kosovrasti, Klajdi, Hedger, Adam K., Lockbaum, Gordon J., Timm, Jennifer, Ali, Akbar, Kurt Yilmaz, Nese, Schiffer, Celia A.
Publicado 2020

Crystal structure of APOBEC3A bound to single-stranded DNA reveals structural basis for cytidine deamination and specificity

por Kouno, Takahide, Silvas, Tania V., Hilbert, Brendan J., Shandilya, Shivender M. D., Bohn, Markus F., Kelch, Brian A., Royer, William E., Somasundaran, Mohan, Kurt Yilmaz, Nese, Matsuo, Hiroshi, Schiffer, Celia A.
Publicado 2017

Defining the substrate envelope of SARS-CoV-2 main protease to predict and avoid drug resistance

por Shaqra, Ala M., Zvornicanin, Sarah N., Huang, Qiu Yu J., Lockbaum, Gordon J., Knapp, Mark, Tandeske, Laura, Bakan, David T., Flynn, Julia, Bolon, Daniel N. A., Moquin, Stephanie, Dovala, Dustin, Kurt Yilmaz, Nese, Schiffer, Celia A.
Publicado 2022

Structural Determination of the Broadly Reactive Anti-IGHV1-69 Anti-idiotypic Antibody G6 and Its Idiotope

por Avnir, Yuval, Prachanronarong, Kristina L., Zhang, Zhen, Hou, Shurong, Peterson, Eric C., Sui, Jianhua, Zayed, Hatem, Kurella, Vinodh B., McGuire, Andrew T., Stamatatos, Leonidas, Hilbert, Brendan J., Bohn, Markus-Frederik, Kowalik, Timothy F., Jensen, Jeffrey D., Finberg, Robert W., Wang, Jennifer P., Goodall, Margaret, Jefferis, Roy, Zhu, Quan, Kurt Yilmaz, Nese, Schiffer, Celia A., Marasco, Wayne A.
Publicado 2017

A cross-reactive human IgA monoclonal antibody blocks SARS-CoV-2 spike-ACE2 interaction

por Ejemel, Monir, Li, Qi, Hou, Shurong, Schiller, Zachary A., Tree, Julia A., Wallace, Aaron, Amcheslavsky, Alla, Kurt Yilmaz, Nese, Buttigieg, Karen R., Elmore, Michael J., Godwin, Kerry, Coombes, Naomi, Toomey, Jacqueline R., Schneider, Ryan, Ramchetty, Anudeep S., Close, Brianna J., Chen, Da-Yuan, Conway, Hasahn L., Saeed, Mohsan, Ganesa, Chandrashekar, Carroll, Miles W., Cavacini, Lisa A., Klempner, Mark S., Schiffer, Celia A., Wang, Yang
Publicado 2020