Developing a new class of engineered live bacterial therapeutics to treat human diseases

por Charbonneau, Mark R., Isabella, Vincent M., Li, Ning, Kurtz, Caroline B.
Publicado 2020

Guanylate cyclase-C/cGMP: an emerging pathway in the regulation of visceral pain

por Hannig, Gerhard, Tchernychev, Boris, Kurtz, Caroline B., Bryant, Alexander P., Currie, Mark G., Silos-Santiago, Inmaculada
Publicado 2014

Assessment of treatment response in chronic constipation clinical trials

por Ervin, Claire M, Fehnel, Sheri E, Baird, Mollie J, Carson, Robyn T, Johnston, Jeffrey M, Shiff, Steven J, Kurtz, Caroline B, Mangel, Allen W
Publicado 2014

Psychometric validation of patient-reported outcome measures assessing chronic constipation

por Nelson, Lauren M, Williams, Valerie SL, Fehnel, Sheri E, Carson, Robyn T, MacDougall, James, Baird, Mollie J, Tourkodimitris, Stavros, Kurtz, Caroline B, Johnston, Jeffrey M
Publicado 2014

Linaclotide in Chronic Idiopathic Constipation Patients with Moderate to Severe Abdominal Bloating: A Randomized, Controlled Trial

por Lacy, Brian E., Schey, Ron, Shiff, Steven J., Lavins, Bernard J., Fox, Susan M., Jia, Xinwei D., Blakesley, Rick E., Hao, Xinming, Cronin, Jacquelyn A., Currie, Mark G., Kurtz, Caroline B., Johnston, Jeffrey M., Lembo, Anthony J.
Publicado 2015

An engineered bacterial therapeutic lowers urinary oxalate in preclinical models and in silico simulations of enteric hyperoxaluria

por Lubkowicz, David, Horvath, Nicholas G, James, Michael J, Cantarella, Pasquale, Renaud, Lauren, Bergeron, Christopher G, Shmueli, Ron B, Anderson, Cami, Gao, Jian‐Rong, Kurtz, Caroline B, Perreault, Mylene, Charbonneau, Mark R, Isabella, Vincent M, Hava, David L
Publicado 2022

Low-Dose Linaclotide (72 μg) for Chronic Idiopathic Constipation: A 12-Week, Randomized, Double-Blind, Placebo-Controlled Trial

por Schoenfeld, Philip, Lacy, Brian E, Chey, William D, Lembo, Anthony J, Kurtz, Caroline B, Reasner, David S, Bochenek, Wieslaw, Tripp, Kenneth, Currie, Mark G, Fox, Susan M, Blakesley, Rick E, O’Dea, Christopher R, Omniewski, Nicholas D, Hall, Michael L
Publicado 2018

A 12-Week, Randomized, Controlled Trial With a 4-Week Randomized Withdrawal Period to Evaluate the Efficacy and Safety of Linaclotide in Irritable Bowel Syndrome With Constipation

por Rao, Satish, Lembo, Anthony J, Shiff, Steven J, Lavins, Bernard J, Currie, Mark G, Jia, Xinwei D, Shi, Kelvin, MacDougall, James E, Shao, James Z, Eng, Paul, Fox, Susan M, Schneier, Harvey A, Kurtz, Caroline B, Johnston, Jeffrey M
Publicado 2012