Do We Need Anti-Prionic Compounds to Treat Alzheimer’s Disease?

por Willbold, Dieter, Kutzsche, Janine
Publicado 2019

Oral Treatment with d-RD2RD2 Impedes Early Disease Mechanisms in SOD1*G93A Transgenic Mice but Does Not Prolong Survival

por Wintz, Katharina, Post, Julia, Langen, Karl-Josef, Willbold, Dieter, Willuweit, Antje, Kutzsche, Janine
Publicado 2023

In Vitro and In Vivo Efficacies of the Linear and the Cyclic Version of an All-d-Enantiomeric Peptide Developed for the Treatment of Alzheimer’s Disease

por Schemmert, Sarah, Camargo, Luana Cristina, Honold, Dominik, Gering, Ian, Kutzsche, Janine, Willuweit, Antje, Willbold, Dieter
Publicado 2021

Aβ oligomer concentration in mouse and human brain and its drug-induced reduction ex vivo

por Kass, Bettina, Schemmert, Sarah, Zafiu, Christian, Pils, Marlene, Bannach, Oliver, Kutzsche, Janine, Bujnicki, Tuyen, Willbold, Dieter
Publicado 2022

A Novel Anti-Inflammatory d-Peptide Inhibits Disease Phenotype Progression in an ALS Mouse Model

por Post, Julia, Kogel, Vanessa, Schaffrath, Anja, Lohmann, Philipp, Shah, N. Jon, Langen, Karl-Josef, Willbold, Dieter, Willuweit, Antje, Kutzsche, Janine
Publicado 2021

Large-Scale Oral Treatment Study with the Four Most Promising D3-Derivatives for the Treatment of Alzheimer’s Disease

por Kutzsche, Janine, Schemmert, Sarah, Tusche, Markus, Neddens, Jörg, Rabl, Roland, Jürgens, Dagmar, Brener, Oleksandr, Willuweit, Antje, Hutter-Paier, Birgit, Willbold, Dieter
Publicado 2017

Sex-Related Motor Deficits in the Tau-P301L Mouse Model

por Camargo, Luana Cristina, Honold, Dominik, Bauer, Robert, Shah, N. Jon, Langen, Karl-Josef, Willbold, Dieter, Kutzsche, Janine, Willuweit, Antje, Schemmert, Sarah
Publicado 2021

Safety and pharmacokinetics of the orally available antiprionic compound PRI‐002: A single and multiple ascending dose phase I study

por Kutzsche, Janine, Jürgens, Dagmar, Willuweit, Antje, Adermann, Knut, Fuchs, Carola, Simons, Stefanie, Windisch, Manfred, Hümpel, Michael, Rossberg, Wolfgang, Wolzt, Michael, Willbold, Dieter
Publicado 2020

Oral Treatment with RD2RD2 Impedes Development of Motoric Phenotype and Delays Symptom Onset in SOD1(G93A) Transgenic Mice

por Post, Julia, Schaffrath, Anja, Gering, Ian, Hartwig, Sonja, Lehr, Stefan, Shah, N. Jon, Langen, Karl-Josef, Willbold, Dieter, Kutzsche, Janine, Willuweit, Antje
Publicado 2021

PEAβ Triggers Cognitive Decline and Amyloid Burden in a Novel Mouse Model of Alzheimer’s Disease

por Camargo, Luana Cristina, Schöneck, Michael, Sangarapillai, Nivethini, Honold, Dominik, Shah, N. Jon, Langen, Karl-Josef, Willbold, Dieter, Kutzsche, Janine, Schemmert, Sarah, Willuweit, Antje
Publicado 2021

Competitive Mirror Image Phage Display Derived Peptide Modulates Amyloid Beta Aggregation and Toxicity

por Rudolph, Stephan, Klein, Antonia Nicole, Tusche, Markus, Schlosser, Christine, Elfgen, Anne, Brener, Oleksandr, Teunissen, Charlotte, Gremer, Lothar, Funke, Susanne Aileen, Kutzsche, Janine, Willbold, Dieter
Publicado 2016

Correction: Competitive Mirror Image Phage Display Derived Peptide Modulates Amyloid Beta Aggregation and Toxicity

por Rudolph, Stephan, Klein, Antonia Nicole, Tusche, Markus, Schlosser, Christine, Elfgen, Anne, Brener, Oleksandr, Teunissen, Charlotte, Gremer, Lothar, Funke, Susanne Aileen, Kutzsche, Janine, Willbold, Dieter
Publicado 2016

Comprehensive Characterization of the Pyroglutamate Amyloid-β Induced Motor Neurodegenerative Phenotype of TBA2.1 Mice

por Dunkelmann, Tina, Schemmert, Sarah, Honold, Dominik, Teichmann, Kerstin, Butzküven, Elke, Demuth, Hans-Ulrich, Shah, Nadim Joni, Langen, Karl-Josef, Kutzsche, Janine, Willbold, Dieter, Willuweit, Antje
Publicado 2018

Aβ Oligomer Elimination Restores Cognition in Transgenic Alzheimer’s Mice with Full-blown Pathology

por Schemmert, Sarah, Schartmann, Elena, Zafiu, Christian, Kass, Bettina, Hartwig, Sonja, Lehr, Stefan, Bannach, Oliver, Langen, Karl-Josef, Shah, Nadim Joni, Kutzsche, Janine, Willuweit, Antje, Willbold, Dieter
Publicado 2018

Optimization of the All-D Peptide D3 for Aβ Oligomer Elimination

por Klein, Antonia Nicole, Ziehm, Tamar, Tusche, Markus, Buitenhuis, Johan, Bartnik, Dirk, Boeddrich, Annett, Wiglenda, Thomas, Wanker, Erich, Funke, Susanne Aileen, Brener, Oleksandr, Gremer, Lothar, Kutzsche, Janine, Willbold, Dieter
Publicado 2016

The Aβ oligomer eliminating D-enantiomeric peptide RD2 improves cognition without changing plaque pathology

por van Groen, Thomas, Schemmert, Sarah, Brener, Oleksandr, Gremer, Lothar, Ziehm, Tamar, Tusche, Markus, Nagel-Steger, Luitgard, Kadish, Inga, Schartmann, Elena, Elfgen, Anne, Jürgens, Dagmar, Willuweit, Antje, Kutzsche, Janine, Willbold, Dieter
Publicado 2017

In Vitro Potency and Preclinical Pharmacokinetic Comparison of All-D-Enantiomeric Peptides Developed for the Treatment of Alzheimer’s Disease

por Schartmann, Elena, Schemmert, Sarah, Niemietz, Nicole, Honold, Dominik, Ziehm, Tamar, Tusche, Markus, Elfgen, Anne, Gering, Ian, Brener, Oleksandr, Shah, Nadim Joni, Langen, Karl-Josef, Kutzsche, Janine, Willbold, Dieter, Willuweit, Antje
Publicado 2018

Preclinical Pharmacokinetic Studies of the Tritium Labelled D-Enantiomeric Peptide D3 Developed for the Treatment of Alzheimer´s Disease

por Jiang, Nan, Leithold, Leonie H. E., Post, Julia, Ziehm, Tamar, Mauler, Jörg, Gremer, Lothar, Cremer, Markus, Schartmann, Elena, Shah, N. Jon, Kutzsche, Janine, Langen, Karl-Josef, Breitkreutz, Jörg, Willbold, Dieter, Willuweit, Antje
Publicado 2015

Metabolic resistance of the D-peptide RD2 developed for direct elimination of amyloid-β oligomers

por Elfgen, Anne, Hupert, Michelle, Bochinsky, Kevin, Tusche, Markus, González de San Román Martin, Estibaliz, Gering, Ian, Sacchi, Silvia, Pollegioni, Loredano, Huesgen, Pitter F., Hartmann, Rudolf, Santiago-Schübel, Beatrix, Kutzsche, Janine, Willbold, Dieter
Publicado 2019

Live imaging of prions reveals nascent PrP(Sc) in cell-surface, raft-associated amyloid strings and webs

por Rouvinski, Alexander, Karniely, Sharon, Kounin, Maria, Moussa, Sanaa, Goldberg, Miri D., Warburg, Gabriela, Lyakhovetsky, Roman, Papy-Garcia, Dulce, Kutzsche, Janine, Korth, Carsten, Carlson, George A., Godsave, Susan F., Peters, Peter J., Luhr, Katarina, Kristensson, Krister, Taraboulos, Albert
Publicado 2014