Identification of novel regulators of STAT3 activity

por Parri, Elina, Kuusanmäki, Heikki, van Adrichem, Arjan J., Kaustio, Meri, Wennerberg, Krister
Publicado 2020

Endogenous and combination retinoids are active in myelomonocytic leukemias

por di Martino, Orsola, Niu, Haixia, Hadwiger, Gayla, Kuusanmaki, Heikki, Ferris, Margaret A., Vu, Anh, Beales, Jeremy, Wagner, Carl, Menéndez-Gutiérrez, María P., Ricote, Mercedes, Heckman, Caroline, Welch, John S.
Publicado 2021

Drug sensitivity profiling identifies potential therapies for lymphoproliferative disorders with overactive JAK/STAT3 signaling

por Kuusanmäki, Heikki, Dufva, Olli, Parri, Elina, van Adrichem, Arjan J., Rajala, Hanna, Majumder, Muntasir M., Yadav, Bhagwan, Parsons, Alun, Chan, Wing C., Wennerberg, Krister, Mustjoki, Satu, Heckman, Caroline A.
Publicado 2017

Identification of precision treatment strategies for relapsed/refractory multiple myeloma by functional drug sensitivity testing

por Majumder, Muntasir Mamun, Silvennoinen, Raija, Anttila, Pekka, Tamborero, David, Eldfors, Samuli, Yadav, Bhagwan, Karjalainen, Riikka, Kuusanmäki, Heikki, Lievonen, Juha, Parsons, Alun, Suvela, Minna, Jantunen, Esa, Porkka, Kimmo, Heckman, Caroline A.
Publicado 2017

Standardized assays to monitor drug sensitivity in hematologic cancers

por Ayuda-Durán, Pilar, Hermansen, Johanne U., Giliberto, Mariaserena, Yin, Yanping, Hanes, Robert, Gordon, Sandra, Kuusanmäki, Heikki, Brodersen, Andrea M., Andersen, Aram N., Taskén, Kjetil, Wennerberg, Krister, Enserink, Jorrit M., Skånland, Sigrid S.
Publicado 2023

Phenotype-based drug screening reveals association between venetoclax response and differentiation stage in acute myeloid leukemia

por Kuusanmäki, Heikki, Leppä, Aino-Maija, Pölönen, Petri, Kontro, Mika, Dufva, Olli, Deb, Debashish, Yadav, Bhagwan, Brück, Oscar, Kumar, Ashwini, Everaus, Hele, Gjertsen, Bjørn T., Heinäniemi, Merja, Porkka, Kimmo, Mustjoki, Satu, Heckman, Caroline A.
Publicado 2020

P409: BCL-2/BCL-XL INHIBITION INDUCES APOPTOSIS AND CIRCUMVENTS VENETOCLAX RESISTANCE IN TP53-MUTATED ACUTE MYELOID LEUKEMIA

por Vänttinen, Ida, Kytölä, Sari, Dufva, Olli, Hellesøy, Monica, Gullaksen, Stein-Erik, Ruokoranta, Tanja, Brück, Oscar, Siitonen, Sanna, Ettala, Pia, Pyörälä, Marja, Rimpilainen, Johanna, Siitonen, Timo, Tore Gjertsen, Bjorn, Heckman, Caroline, Kuusanmäki, Heikki, Kontro, Mika
Publicado 2023

Patient-tailored design for selective co-inhibition of leukemic cell subpopulations

por Ianevski, Aleksandr, Lahtela, Jenni, Javarappa, Komal K., Sergeev, Philipp, Ghimire, Bishwa R., Gautam, Prson, Vähä-Koskela, Markus, Turunen, Laura, Linnavirta, Nora, Kuusanmäki, Heikki, Kontro, Mika, Porkka, Kimmo, Heckman, Caroline A., Mattila, Pirkko, Wennerberg, Krister, Giri, Anil K., Aittokallio, Tero
Publicado 2021

P562: CAPILLARY BLOOD SAMPLING ALLOWS FEASIBLE METHOD FOR VENETOCLAX CONCENTRATION MEASUREMENT IN AN ACADEMIC MULTICENTER CLINICAL TRIAL CONTEXT

por Kytölä, Sari, Vänttinen, Ida, Kuusanmäki, Heikki, Ruokoranta, Tanja, Kurkela, Mika, Kiiski, Johanna, Holopainen, Annasofia, Partanen, Anu, Kuusisto, Milla E.L., Koskela, Sirpa, Räty, Riikka, Itälä-Remes, Maija, Ettala, Pia, Rimpiläinen, Johanna, Siitonen, Timo, Pyörälä, Marja, T. Backman, Janne, Niemi, Mikko, Kontro, Mika
Publicado 2023

Bayesian multi-source regression and monocyte-associated gene expression predict BCL-2 inhibitor resistance in acute myeloid leukemia

por White, Brian S., Khan, Suleiman A., Mason, Mike J., Ammad-ud-din, Muhammad, Potdar, Swapnil, Malani, Disha, Kuusanmäki, Heikki, Druker, Brian J., Heckman, Caroline, Kallioniemi, Olli, Kurtz, Stephen E., Porkka, Kimmo, Tognon, Cristina E., Tyner, Jeffrey W., Aittokallio, Tero, Wennerberg, Krister, Guinney, Justin
Publicado 2021

Differentiation status of primary chronic myeloid leukemia cells affects sensitivity to BCR-ABL1 inhibitors

por Pietarinen, Paavo O., Eide, Christopher A., Ayuda-Durán, Pilar, Potdar, Swapnil, Kuusanmäki, Heikki, Andersson, Emma I., Mpindi, John P., Pemovska, Tea, Kontro, Mika, Heckman, Caroline A., Kallioniemi, Olli, Wennerberg, Krister, Hjorth-Hansen, Henrik, Druker, Brian J., Enserink, Jorrit M., Tyner, Jeffrey W., Mustjoki, Satu, Porkka, Kimmo
Publicado 2017

Ex vivo venetoclax sensitivity testing predicts treatment response in acute myeloid leukemia

por Kuusanmäki, Heikki, Kytölä, Sari, Vänttinen, Ida, Ruokoranta, Tanja, Ranta, Amanda, Huuhtanen, Jani, Suvela, Minna, Parsons, Alun, Holopainen, Annasofia, Partanen, Anu, Kuusisto, Milla E.L., Koskela, Sirpa, Räty, Riikka, Itälä-Remes, Maija, Västrik, Imre, Dufva, Olli, Siitonen, Sanna, Porkka, Kimmo, Wennerberg, Krister, Heckman, Caroline A., Ettala, Pia, Pyörälä, Marja, Rimpiläinen, Johanna, Siitonen, Timo, Kontro, Mika
Publicado 2022

Implementing a Functional Precision Medicine Tumor Board for Acute Myeloid Leukemia

por Malani, Disha, Kumar, Ashwini, Brück, Oscar, Kontro, Mika, Yadav, Bhagwan, Hellesøy, Monica, Kuusanmäki, Heikki, Dufva, Olli, Kankainen, Matti, Eldfors, Samuli, Potdar, Swapnil, Saarela, Jani, Turunen, Laura, Parsons, Alun, Västrik, Imre, Kivinen, Katja, Saarela, Janna, Räty, Riikka, Lehto, Minna, Wolf, Maija, Gjertsen, Bjorn Tore, Mustjoki, Satu, Aittokallio, Tero, Wennerberg, Krister, Heckman, Caroline A., Kallioniemi, Olli, Porkka, Kimmo
Publicado 2022

Aggressive natural killer-cell leukemia mutational landscape and drug profiling highlight JAK-STAT signaling as therapeutic target

por Dufva, Olli, Kankainen, Matti, Kelkka, Tiina, Sekiguchi, Nodoka, Awad, Shady Adnan, Eldfors, Samuli, Yadav, Bhagwan, Kuusanmäki, Heikki, Malani, Disha, Andersson, Emma I, Pietarinen, Paavo, Saikko, Leena, Kovanen, Panu E., Ojala, Teija, Lee, Dean A., Loughran, Thomas P., Nakazawa, Hideyuki, Suzumiya, Junji, Suzuki, Ritsuro, Ko, Young Hyeh, Kim, Won Seog, Chuang, Shih-Sung, Aittokallio, Tero, Chan, Wing C., Ohshima, Koichi, Ishida, Fumihiro, Mustjoki, Satu
Publicado 2018

Erythroid/megakaryocytic differentiation confers BCL-XL dependency and venetoclax resistance in acute myeloid leukemia

por Kuusanmäki, Heikki, Dufva, Olli, Vähä-Koskela, Markus, Leppä, Aino-Maija, Huuhtanen, Jani, Vänttinen, Ida, Nygren, Petra, Klievink, Jay, Bouhlal, Jonas, Pölönen, Petri, Zhang, Qi, Adnan-Awad, Shady, Mancebo-Pérez, Cristina, Saad, Joseph, Miettinen, Juho, Javarappa, Komal K., Aakko, Sofia, Ruokoranta, Tanja, Eldfors, Samuli, Heinäniemi, Merja, Theilgaard-Mönch, Kim, Wartiovaara-Kautto, Ulla, Keränen, Mikko, Porkka, Kimmo, Konopleva, Marina, Wennerberg, Krister, Kontro, Mika, Heckman, Caroline A., Mustjoki, Satu
Publicado 2023