mTOR Inhibitors in Cancer: What Can We Learn from Exceptional Responses?()

por Kwiatkowski, David J., Wagle, Nikhil
Publicado 2014

mTORC1 hyperactivation in lymphangioleiomyomatosis leads to ACE2 upregulation in type II pneumocytes: implications for COVID-19

por Tang, Yan, Kwiatkowski, David J., Henske, Elizabeth P.
Publicado 2021

Midkine expression by stem-like tumor cells drives persistence to mTOR inhibition and an immune-suppressive microenvironment

por Tang, Yan, Kwiatkowski, David J., Henske, Elizabeth P.
Publicado 2022

Delayed Retraction of Filopodia in Gelsolin Null Mice

por Lu, Mei, Witke, Walter, Kwiatkowski, David J., Kosik, Kenneth S.
Publicado 1997

Comparisons of CapG and gelsolin-null macrophages: demonstration of a unique role for CapG in receptor-mediated ruffling, phagocytosis, and vesicle rocketing

por Witke, Walter, Li, Wei, Kwiatkowski, David J., Southwick, Frederick S.
Publicado 2001

Design and Generation of MLPA Probe Sets for Combined Copy Number and Small-Mutation Analysis of Human Genes: EGFR as an Example

por Marcinkowska, Malgorzata, Wong, Kwok-Kin, Kwiatkowski, David J., Kozlowski, Piotr
Publicado 2010

Equivalent benefit of mTORC1 blockade and combined PI3K-mTOR blockade in a mouse model of tuberous sclerosis

por Pollizzi, Kristen, Malinowska-Kolodziej, Izabela, Stumm, Michael, Lane, Heidi, Kwiatkowski, David
Publicado 2009

Therapeutic Trial of Metformin and Bortezomib in a Mouse Model of Tuberous Sclerosis Complex (TSC)

por Auricchio, Neil, Malinowska, Izabela, Shaw, Reuben, Manning, Brendan D., Kwiatkowski, David J.
Publicado 2012

Gelsolin Deficiency Blocks Podosome Assembly and Produces Increased Bone Mass and Strength

por Chellaiah, Meenakshi, Kizer, Neil, Silva, Matthew, Alvarez, Ulises, Kwiatkowski, David, Hruska, Keith A.
Publicado 2000

Analysis of a Mouse Skin Model of Tuberous Sclerosis Complex

por Guo, Yanan, Dreier, John R., Cao, Juxiang, Du, Heng, Granter, Scott R., Kwiatkowski, David J.
Publicado 2016

Evaluation of Hsp90 and mTOR inhibitors as potential drugs for the treatment of TSC1/TSC2 deficient cancer

por Mrozek, Evelyn M., Bajaj, Vineeta, Guo, Yanan, Malinowska, Izabela A., Zhang, Jianming, Kwiatkowski, David J.
Publicado 2021

Diagnosis of Mosaic Tuberous Sclerosis Complex Using Next-Generation Sequencing of Subtle or Unusual Cutaneous Findings

por Treichel, Alison M., Boeszoermenyi, Barbara, Lee, Chyi-Chia Richard, Moss, Joel, Kwiatkowski, David J., Darling, Thomas N.
Publicado 2023

Angiomyolipoma Have Common Mutations in TSC2 but No Other Common Genetic Events

por Qin, Wei, Bajaj, Vineeta, Malinowska, Izabela, Lu, Xin, MacConaill, Laura, Wu, Chin-Lee, Kwiatkowski, David J.
Publicado 2011

Tsc1-Tp53 loss induces mesothelioma in mice, and evidence for this mechanism in human mesothelioma

por Guo, Yanan, Chirieac, Lucian R., Bueno, Raphael, Pass, Harvey, Wu, Wenhao, Malinowska, Izabela A., Kwiatkowski, David J.
Publicado 2013

Response to everolimus is seen in TSC-associated SEGAs and angiomyolipomas independent of mutation type and site in TSC1 and TSC2

por Kwiatkowski, David J, Palmer, Michael R, Jozwiak, Sergiusz, Bissler, John, Franz, David, Segal, Scott, Chen, David, Sampson, Julian R
Publicado 2015

mTORC1-S6K Activation by Endotoxin Contributes to Cytokine Up-Regulation and Early Lethality in Animals

por Lee, Po-Shun, Wilhelmson, Anna S. K., Hubner, Anton P., Reynolds, Samuel B., Gallacchi, Dana A., Chiou, Terry T., Kwiatkowski, David J.
Publicado 2010

mTORC1 upregulates B7-H3/CD276 to inhibit antitumor T cells and drive tumor immune evasion

por Liu, Heng-Jia, Du, Heng, Khabibullin, Damir, Zarei, Mahsa, Wei, Kevin, Freeman, Gordon J., Kwiatkowski, David J., Henske, Elizabeth P.
Publicado 2023

Identification of Nine Genomic Regions of Amplification in Urothelial Carcinoma, Correlation with Stage, and Potential Prognostic and Therapeutic Value

por Chekaluk, Yvonne, Wu, Chin-Lee, Rosenberg, Jonathan, Riester, Markus, Dai, Qishan, Lin, Sharron, Guo, Yanan, McDougal, W. Scott, Kwiatkowski, David J.
Publicado 2013

Ultrasensitive profiling of UV-induced mutations identifies thousands of subclinical facial tumors in tuberous sclerosis complex

por Klonowska, Katarzyna, Grevelink, Joannes M., Giannikou, Krinio, Ogorek, Barbara A., Herbert, Zachary T., Thorner, Aaron R., Darling, Thomas N., Moss, Joel, Kwiatkowski, David J.
Publicado 2022

Bi-steric mTORC1 inhibitors induce apoptotic cell death in tumor models with hyperactivated mTORC1

por Du, Heng, Yang, Yu Chi, Liu, Heng-Jia, Yuan, Min, Asara, John M., Wong, Kwok-Kin, Henske, Elizabeth P., Singh, Mallika, Kwiatkowski, David J.
Publicado 2023