Improvements in the Tolerability Profile of 2′-O-Methoxyethyl Chimeric Antisense Oligonucleotides in Parallel with Advances in Design, Screening, and Other Methods

por Partridge, Wesley, Xia, Shuting, Kwoh, T. Jesse, Bhanot, Sanjay, Geary, Richard S., Baker, Brenda F.
Publicado 2021

Integrated Assessment of Phase 2 Data on GalNAc(3)-Conjugated 2′-O-Methoxyethyl-Modified Antisense Oligonucleotides

por Baker, Brenda F., Xia, Shuting, Partridge, Wesley, Kwoh, T. Jesse, Tsimikas, Sotirios, Bhanot, Sanjay, Geary, Richard S.
Publicado 2023

Correlations between preclinical BJAB assay ranking of antisense drugs and clinical trial adverse events

por Partridge, Wesley, Burel, Sebastien A., Ferng, Annie, Xia, Shuting, Kwoh, T. Jesse, Henry, Scott P., Baker, Brenda F.
Publicado 2023

The Effects of 2′-O-Methoxyethyl Oligonucleotides on Renal Function in Humans

por Crooke, Stanley T., Baker, Brenda F., Pham, Nguyen C., Hughes, Steven G., Kwoh, T. Jesse, Cai, Danlin, Tsimikas, Sotirios, Geary, Richard S., Bhanot, Sanjay
Publicado 2018

Preclinical and Phase 1 Assessment of Antisense Oligonucleotide Bepirovirsen in Hepatitis B Virus–Transgenic Mice and Healthy Human Volunteers: Support for Clinical Dose Selection...

por Han, Kelong, Theodore, Dickens, McMullen, Gina, Swayze, Eric, McCaleb, Michael, Billioud, Gaetan, Wieland, Stefan, Hood, Steve, Paff, Melanie, Bennett, C. Frank, Kwoh, T. Jesse
Publicado 2022

The Effects of 2′-O-Methoxyethyl Containing Antisense Oligonucleotides on Platelets in Human Clinical Trials

por Crooke, Stanley T., Baker, Brenda F., Witztum, Joseph L., Kwoh, T. Jesse, Pham, Nguyen C., Salgado, Nelson, McEvoy, Bradley W., Cheng, Wei, Hughes, Steven G., Bhanot, Sanjay, Geary, Richard S.
Publicado 2017

Integrated Safety Assessment of 2′-O-Methoxyethyl Chimeric Antisense Oligonucleotides in NonHuman Primates and Healthy Human Volunteers

por Crooke, Stanley T, Baker, Brenda F, Kwoh, T Jesse, Cheng, Wei, Schulz, Dan J, Xia, Shuting, Salgado, Nelson, Bui, Huynh-Hoa, Hart, Christopher E, Burel, Sebastien A, Younis, Husam S, Geary, Richard S, Henry, Scott P, Bhanot, Sanjay
Publicado 2016

Safety, tolerability and antiviral activity of the antisense oligonucleotide bepirovirsen in patients with chronic hepatitis B: a phase 2 randomized controlled trial

por Yuen, Man-Fung, Heo, Jeong, Jang, Jeong-Won, Yoon, Jung-Hwan, Kweon, Young-Oh, Park, Sung-Jae, Tami, Yvonne, You, Shihyun, Yates, Phillip, Tao, Yu, Cremer, Jennifer, Campbell, Fiona, Elston, Robert, Theodore, Dickens, Paff, Melanie, Bennett, C. Frank, Kwoh, T. Jesse
Publicado 2021