Comparing distributions of polygenic risk scores of type 2 diabetes and coronary heart disease within different populations

por Reisberg, Sulev, Iljasenko, Tatjana, Läll, Kristi, Fischer, Krista, Vilo, Jaak
Publicado 2017

Personalized risk prediction for type 2 diabetes: the potential of genetic risk scores

por Läll, Kristi, Mägi, Reedik, Morris, Andrew, Metspalu, Andres, Fischer, Krista
Publicado 2017

Validating the doubly weighted genetic risk score for the prediction of type 2 diabetes in the Lifelines and Estonian Biobank cohorts

por Pärna, Katri, Snieder, Harold, Läll, Kristi, Fischer, Krista, Nolte, Ilja
Publicado 2020

Genetic insights into the age-specific biological mechanisms governing human ovarian aging

por Ojavee, Sven E., Darrous, Liza, Patxot, Marion, Läll, Kristi, Fischer, Krista, Mägi, Reedik, Kutalik, Zoltan, Robinson, Matthew R.
Publicado 2023

Polygenic prediction of breast cancer: comparison of genetic predictors and implications for risk stratification

por Läll, Kristi, Lepamets, Maarja, Palover, Marili, Esko, Tõnu, Metspalu, Andres, Tõnisson, Neeme, Padrik, Peeter, Mägi, Reedik, Fischer, Krista
Publicado 2019

Contribution of schizophrenia polygenic burden to longitudinal phenotypic variance in 22q11.2 deletion syndrome

por Alver, Maris, Mancini, Valentina, Läll, Kristi, Schneider, Maude, Romano, Luciana, Mägi, Reedik, Dermitzakis, Emmanouil T., Eliez, Stephan, Reymond, Alexandre
Publicado 2022

Advancing our understanding of genetic risk factors and potential personalized strategies for pelvic organ prolapse

por Pujol-Gualdo, Natàlia, Läll, Kristi, Lepamets, Maarja, Rossi, Henna-Riikka, Arffman, Riikka K., Piltonen, Terhi T., Mägi, Reedik, Laisk, Triin
Publicado 2022

Improving GWAS discovery and genomic prediction accuracy in biobank data

por Orliac, Etienne J., Trejo Banos, Daniel, Ojavee, Sven E., Läll, Kristi, Mägi, Reedik, Visscher, Peter M., Robinson, Matthew R.
Publicado 2022

Ancestry deconvolution and partial polygenic score can improve susceptibility predictions in recently admixed individuals

por Marnetto, Davide, Pärna, Katri, Läll, Kristi, Molinaro, Ludovica, Montinaro, Francesco, Haller, Toomas, Metspalu, Mait, Mägi, Reedik, Fischer, Krista, Pagani, Luca
Publicado 2020

GWAS meta-analyses clarify the genetics of cervical phenotypes and inform risk stratification for cervical cancer

por Koel, Mariann, Võsa, Urmo, Jõeloo, Maarja, Läll, Kristi, Gualdo, Natàlia P, Laivuori, Hannele, Lemmelä, Susanna, Daly, Mark, Palta, Priit, Mägi, Reedik, Laisk, Triin
Publicado 2023

Genomic architecture and prediction of censored time-to-event phenotypes with a Bayesian genome-wide analysis

por Ojavee, Sven E., Kousathanas, Athanasios, Trejo Banos, Daniel, Orliac, Etienne J., Patxot, Marion, Läll, Kristi, Mägi, Reedik, Fischer, Krista, Kutalik, Zoltan, Robinson, Matthew R.
Publicado 2021

Stratification of Type 2 Diabetes by Age of Diagnosis in the UK Biobank Reveals Subgroup-Specific Genetic Associations and Causal Risk Profiles

por Noordam, Raymond, Läll, Kristi, Smit, Roelof A.J., Laisk, Triin, Metspalu, Andres, Esko, Tõnu, Milani, Lili, Loos, Ruth J.F., Mägi, Reedik, Willems van Dijk, Ko, van Heemst, Diana
Publicado 2021

Effectiveness and feasibility of cardiovascular disease personalized prevention on high polygenic risk score subjects: a randomized controlled pilot study

por Viigimaa, Margus, Jürisson, Mikk, Pisarev, Heti, Kalda, Ruth, Alavere, Helene, Irs, Alar, Saar, Aet, Fischer, Krista, Läll, Kristi, Kruuv-Käo, Krista, Mars, Nina, Widen, Elisabeth, Ripatti, Samuli, Metspalu, Andres
Publicado 2022

Genomics of 1 million parent lifespans implicates novel pathways and common diseases and distinguishes survival chances

por Timmers, Paul RHJ, Mounier, Ninon, Lall, Kristi, Fischer, Krista, Ning, Zheng, Feng, Xiao, Bretherick, Andrew D, Clark, David W, Shen, Xia, Esko, Tõnu, Kutalik, Zoltán, Wilson, James F, Joshi, Peter K
Publicado 2019

Development and validation of two SCORE-based cardiovascular risk prediction models for Eastern Europe: a multicohort study

por Tillmann, Taavi, Läll, Kristi, Dukes, Oliver, Veronesi, Giovanni, Pikhart, Hynek, Peasey, Anne, Kubinova, Ruzena, Kozela, Magdalena, Pajak, Andrzej, Nikitin, Yuri, Malyutina, Sofia, Metspalu, Andres, Esko, Tõnu, Fischer, Krista, Kivimäki, Mika, Bobak, Martin
Publicado 2020

Genetic and modifiable risk factors combine multiplicatively in common disease

por Pang, Shichao, Yengo, Loic, Nelson, Christopher P., Bourier, Felix, Zeng, Lingyao, Li, Ling, Kessler, Thorsten, Erdmann, Jeanette, Mägi, Reedik, Läll, Kristi, Metspalu, Andres, Mueller-Myhsok, Bertram, Samani, Nilesh J., Visscher, Peter M., Schunkert, Heribert
Publicado 2022

Recall by genotype and cascade screening for familial hypercholesterolemia in a population-based biobank from Estonia

por Alver, Maris, Palover, Marili, Saar, Aet, Läll, Kristi, Zekavat, Seyedeh Maryam, Tõnisson, Neeme, Leitsalu, Liis, Reigo, Anu, Nikopensius, Tiit, Ainla, Tiia, Kals, Mart, Mägi, Reedik, Gabriel, Stacey B., Eha, Jaan, Lander, Eric S., Irs, Alar, Philippakis, Anthony, Marandi, Toomas, Natarajan, Pradeep, Metspalu, Andres, Kathiresan, Sekar, Esko, Tõnu
Publicado 2018

Genome-wide risk prediction of common diseases across ancestries in one million people

por Mars, Nina, Kerminen, Sini, Feng, Yen-Chen A., Kanai, Masahiro, Läll, Kristi, Thomas, Laurent F., Skogholt, Anne Heidi, della Briotta Parolo, Pietro, Neale, Benjamin M., Smoller, Jordan W., Gabrielsen, Maiken E., Hveem, Kristian, Mägi, Reedik, Matsuda, Koichi, Okada, Yukinori, Pirinen, Matti, Palotie, Aarno, Ganna, Andrea, Martin, Alicia R., Ripatti, Samuli
Publicado 2022

Global Biobank analyses provide lessons for developing polygenic risk scores across diverse cohorts

por Wang, Ying, Namba, Shinichi, Lopera, Esteban, Kerminen, Sini, Tsuo, Kristin, Läll, Kristi, Kanai, Masahiro, Zhou, Wei, Wu, Kuan-Han, Favé, Marie-Julie, Bhatta, Laxmi, Awadalla, Philip, Brumpton, Ben, Deelen, Patrick, Hveem, Kristian, Lo Faro, Valeria, Mägi, Reedik, Murakami, Yoshinori, Sanna, Serena, Smoller, Jordan W., Uzunovic, Jasmina, Wolford, Brooke N., Willer, Cristen, Gamazon, Eric R., Cox, Nancy J., Surakka, Ida, Okada, Yukinori, Martin, Alicia R., Hirbo, Jibril
Publicado 2023

Estimation of recurrent atherosclerotic cardiovascular event risk in patients with established cardiovascular disease: the updated SMART2 algorithm

por Hageman, Steven H J, McKay, Ailsa J, Ueda, Peter, Gunn, Laura H, Jernberg, Tomas, Hagström, Emil, Bhatt, Deepak L, Steg, Ph. Gabriel, Läll, Kristi, Mägi, Reedik, Gynnild, Mari Nordbø, Ellekjær, Hanne, Saltvedt, Ingvild, Tuñón, José, Mahíllo, Ignacio, Aceña, Álvaro, Kaminski, Karol, Chlabicz, Malgorzata, Sawicka, Emilia, Tillman, Taavi, McEvoy, John W, Di Angelantonio, Emanuele, Graham, Ian, De Bacquer, Dirk, Ray, Kausik K, Dorresteijn, Jannick A N, Visseren, Frank L J
Publicado 2022