The Pharmacological or Genetic Blockade of Endogenous De Novo Fatty Acid Synthesis Does Not Increase the Uptake of Exogenous Lipids in Ovarian Cancer Cells

por Grunt, Thomas W., Lemberger, Lisa, Colomer, Ramón, López−Rodríguez, María Luz, Wagner, Renate
Publicado 2021

Membrane disruption, but not metabolic rewiring, is the key mechanism of anticancer-action of FASN-inhibitors: a multi-omics analysis in ovarian cancer

por Grunt, Thomas W., Slany, Astrid, Semkova, Mariya, Colomer, Ramón, López-Rodríguez, María Luz, Wuczkowski, Michael, Wagner, Renate, Gerner, Christopher, Stübiger, Gerald
Publicado 2020

A novel inhibitor of fatty acid synthase shows activity against HER2+ breast cancer xenografts and is active in anti-HER2 drug-resistant cell lines

por Puig, Teresa, Aguilar, Helena, Cufí, Sílvia, Oliveras, Glòria, Turrado, Carlos, Ortega-Gutiérrez, Sílvia, Benhamú, Bellinda, López-Rodríguez, María Luz, Urruticoechea, Ander, Colomer, Ramon
Publicado 2011

Essentiality of fatty acid synthase in the 2D to anchorage-independent growth transition in transforming cells

por Bueno, Maria J., Jimenez-Renard, Veronica, Samino, Sara, Capellades, Jordi, Junza, Alejandra, López-Rodríguez, María Luz, Garcia-Carceles, Javier, Lopez-Fabuel, Irene, Bolaños, Juan P., Chandel, Navdeep S., Yanes, Oscar, Colomer, Ramon, Quintela-Fandino, Miguel
Publicado 2019

Multi-level suppression of receptor-PI3K-mTORC1 by fatty acid synthase inhibitors is crucial for their efficacy against ovarian cancer cells

por Wagner, Renate, Stübiger, Gerald, Veigel, Daniel, Wuczkowski, Michael, Lanzerstorfer, Peter, Weghuber, Julian, Karteris, Emmanouil, Nowikovsky, Karin, Wilfinger-Lutz, Nastasia, Singer, Christian F., Colomer, Ramón, Benhamú, Bellinda, López-Rodríguez, María Luz, Valent, Peter, Grunt, Thomas W.
Publicado 2017