Endocytic pathways mediating oligomeric Aβ42 neurotoxicity

por Yu, Chunjiang, Nwabuisi-Heath, Evelyn, Laxton, Kevin, LaDu, Mary Jo
Publicado 2010

ApoE4 delays dendritic spine formation during neuron development and accelerates loss of mature spines in vitro

por Nwabuisi-Heath, Evelyn, Rebeck, G. William, LaDu, Mary Jo, Yu, Chunjiang
Publicado 2014

Human APOE4 increases microglia reactivity at Aβ plaques in a mouse model of Aβ deposition

por Rodriguez, Gustavo A, Tai, Leon M, LaDu, Mary Jo, Rebeck, G William
Publicado 2014

The generation and function of soluble apoE receptors in the CNS

por Rebeck, G William, LaDu, Mary Jo, Estus, Steven, Bu, Guojun, Weeber, Edwin J
Publicado 2006

Introducing Human APOE into Aβ Transgenic Mouse Models

por Tai, Leon M., Youmans, Katherine L., Jungbauer, Lisa, Yu, Chunjiang, LaDu, Mary Jo
Publicado 2011

ApoE isoform-dependent changes in hippocampal synaptic function

por Korwek, Kimberly M, Trotter, Justin H, LaDu, Mary Jo, Sullivan, Patrick M, Weeber, Edwin J
Publicado 2009

Soluble apoE/Aβ complex: mechanism and therapeutic target for APOE4-induced AD risk

por Tai, Leon M, Mehra, Shipra, Shete, Varsha, Estus, Steve, Rebeck, G William, Bu, Guojun, LaDu, Mary Jo
Publicado 2014

Arabidopsis thaliana extracts optimized for polyphenols production as potential therapeutics for the APOE-modulated neuroinflammation characteristic of Alzheimer’s disease in vitro...

por Ghura, Shivesh, Tai, Leon, Zhao, Ming, Collins, Nicole, Che, Chun-Tao, Warpeha, Katherine M., LaDu, Mary Jo
Publicado 2016

Synergistic effects of APOE and sex on the gut microbiome of young EFAD transgenic mice

por Maldonado Weng, Juan, Parikh, Ishita, Naqib, Ankur, York, Jason, Green, Stefan J., Estus, Steven, LaDu, Mary Jo
Publicado 2019

Development and validation of a yeast high-throughput screen for inhibitors of Aβ(42) oligomerization

por Park, Sei-Kyoung, Pegan, Scott D., Mesecar, Andrew D., Jungbauer, Lisa M., LaDu, Mary Jo, Liebman, Susan W.
Publicado 2011

Apolipoprotein E as a β-amyloid-independent factor in Alzheimer’s disease

por Wolf, Andrew B, Valla, Jon, Bu, Guojun, Kim, Jungsu, LaDu, Mary Jo, Reiman, Eric M, Caselli, Richard J
Publicado 2013

Low-Density Lipoprotein Receptor-Related Protein 1 (LRP1) Mediates Neuronal Aβ42 Uptake and Lysosomal Trafficking

por Fuentealba, Rodrigo A., Liu, Qiang, Zhang, Juan, Kanekiyo, Takahisa, Hu, Xiaoyan, Lee, Jin-Moo, LaDu, Mary Jo, Bu, Guojun
Publicado 2010

A small-molecule TLR4 antagonist reduced neuroinflammation in female E4FAD mice

por Balu, Deebika, Valencia-Olvera, Ana C., Nguyen, Austin, Patnam, Mehul, York, Jason, Peri, Francesco, Neumann, Frank, LaDu, Mary Jo, Tai, Leon M.
Publicado 2023

Metabolomic analysis of a selective ABCA1 inducer in obesogenic challenge provides a rationale for therapeutic development

por Lewandowski, Cutler T., Khan, Md.Wasim, BenAissa, Manel, Dubrovskyi, Oleksii, Ackerman-Berrier, Martha, LaDu, Mary Jo, Layden, Brian T., Thatcher, Gregory R.J.
Publicado 2021

APOE genotype and sex modulate Alzheimer’s disease pathology in aged EFAD transgenic mice

por Balu, Deebika, Valencia-Olvera, Ana C., Islam, Zarak, Mielczarek, Clare, Hansen, Allison, Perez Ramos, Tamara M., York, Jason, LaDu, Mary Jo, Tai, Leon M.
Publicado 2023

Genetics ignite focus on microglial inflammation in Alzheimer’s disease

por Malik, Manasi, Parikh, Ishita, Vasquez, Jared B., Smith, Conor, Tai, Leon, Bu, Guojun, LaDu, Mary Jo, Fardo, David W., Rebeck, G. William, Estus, Steven
Publicado 2015

Inhibition of ACAT as a Therapeutic Target for Alzheimer’s Disease Is Independent of ApoE4 Lipidation

por Valencia-Olvera, Ana C., Balu, Deebika, Faulk, Naomi, Amiridis, Aspasia, Wang, Yueting, Pham, Christine, Avila-Munoz, Eva, York, Jason M., Thatcher, Gregory R. J., LaDu, Mary Jo
Publicado 2023

Murine Gut Microbiome Association With APOE Alleles

por Parikh, Ishita J., Estus, Janice L., Zajac, Diana J., Malik, Manasi, Maldonado Weng, Juan, Tai, Leon M., Chlipala, George E., LaDu, Mary Jo, Green, Stefan J., Estus, Steven
Publicado 2020

A small molecule ApoE4-targeted therapeutic candidate that normalizes sirtuin 1 levels and improves cognition in an Alzheimer’s disease mouse model

por Campagna, Jesus, Spilman, Patricia, Jagodzinska, Barbara, Bai, Dongsheng, Hatami, Asa, Zhu, Chunni, Bilousova, Tina, Jun, Michael, Elias, Chris Jean, Pham, Johnny, Cole, Gregory, LaDu, Mary Jo, Jung, Michael E., Bredesen, Dale E., John, Varghese
Publicado 2018

APOE‐modulated Aβ‐induced neuroinflammation in Alzheimer's disease: current landscape, novel data, and future perspective

por Tai, Leon M., Ghura, Shivesh, Koster, Kevin P., Liakaite, Vaiva, Maienschein‐Cline, Mark, Kanabar, Pinal, Collins, Nicole, Ben‐Aissa, Manel, Lei, Arden Zhengdeng, Bahroos, Neil, Green, Stefan J., Hendrickson, Bill, Van Eldik, Linda J., LaDu, Mary Jo
Publicado 2015