Structural reorganization of SHP2 by oncogenic mutations and implications for oncoprotein resistance to allosteric inhibition

por LaRochelle, Jonathan R., Fodor, Michelle, Vemulapalli, Vidyasiri, Mohseni, Morvarid, Wang, Ping, Stams, Travis, LaMarche, Matthew J., Chopra, Rajiv, Acker, Michael G., Blacklow, Stephen C.
Publicado 2018

Resistance to allosteric SHP2 inhibition in FGFR-driven cancers through rapid feedback activation of FGFR

por Lu, Hengyu, Liu, Chen, Huynh, Hung, Le, Thi Bich Uyen, LaMarche, Matthew J., Mohseni, Morvarid, Engelman, Jeffrey A., Hammerman, Peter S., Caponigro, Giordano, Hao, Huai-Xiang
Publicado 2020

Time-resolved phosphoproteomics reveals scaffolding and catalysis-responsive patterns of SHP2-dependent signaling

por Vemulapalli, Vidyasiri, Chylek, Lily A, Erickson, Alison, Pfeiffer, Anamarija, Gabriel, Khal-Hentz, LaRochelle, Jonathan, Subramanian, Kartik, Cao, Ruili, Stegmaier, Kimberley, Mohseni, Morvarid, LaMarche, Matthew J, Acker, Michael G, Sorger, Peter K, Gygi, Steven P, Blacklow, Stephen C
Publicado 2021

SHP2 blockade enhances anti-tumor immunity via tumor cell intrinsic and extrinsic mechanisms

por Wang, Ye, Mohseni, Morvarid, Grauel, Angelo, Diez, Javier Estrada, Guan, Wei, Liang, Simon, Choi, Jiyoung Elizabeth, Pu, Minying, Chen, Dongshu, Laszewski, Tyler, Schwartz, Stephanie, Gu, Jane, Mansur, Leandra, Burks, Tyler, Brodeur, Lauren, Velazquez, Roberto, Kovats, Steve, Pant, Bhavesh, Buruzula, Giri, Deng, Emily, Chen, Julie T., Sari-Sarraf, Farid, Dornelas, Christina, Varadarajan, Malini, Yu, Haiyan, Liu, Chen, Lim, Joanne, Hao, Huai-Xiang, Jiang, Xiaomo, Malamas, Anthony, LaMarche, Matthew J., Geyer, Felipe Correa, McLaughlin, Margaret, Costa, Carlotta, Wagner, Joel, Ruddy, David, Jayaraman, Pushpa, Kirkpatrick, Nathaniel D., Zhang, Pu, Iartchouk, Oleg, Aardalen, Kimberly, Cremasco, Viviana, Dranoff, Glenn, Engelman, Jeffrey A., Silver, Serena, Wang, Hongyun, Hastings, William D., Goldoni, Silvia
Publicado 2021