A Novel Probe for Spliceosomal Proteins that Induces Autophagy and Death of Melanoma Cells Reveals New Targets for Melanoma Drug Discovery

por Palrasu, Manikandan, Knapinska, Anna M., Diez, Juan, Smith, Lyndsay, LaVoi, Travis, Giulianotti, Marc, Houghten, Richard A., Fields, Gregg B., Minond, Dmitriy
Publicado 2019

Novel Pyrrolidine Diketopiperazines Selectively Inhibit Melanoma Cells via Induction of Late-Onset Apoptosis

por Onwuha-Ekpete, Lillian, Tack, Lisa, Knapinska, Anna, Smith, Lyndsay, Kaushik, Gaurav, LaVoi, Travis, Giulianotti, Marc, Houghten, Richard A., Fields, Gregg B., Minond, Dmitriy
Publicado 2014

The Parallel Structure–Activity Relationship Screening of Three Compounds Identifies the Common Agonist Pharmacophore of Pyrrolidine Bis-Cyclic Guanidine Melanocortin-3 Receptor (M...

por Ericson, Mark D., Freeman, Katie T., LaVoi, Travis M., Donow, Haley M., Santos, Radleigh G., Giulianotti, Marc A., Pinilla, Clemencia, Houghten, Richard A., Haskell-Luevano, Carrie
Publicado 2023

Direct Phenotypic Screening in Mice: Identification of Individual, Novel Antinociceptive Compounds from a Library of 734 821 Pyrrolidine Bis-piperazines

por Houghten, Richard A., Ganno, Michelle L., McLaughlin, Jay P., Dooley, Colette T., Eans, Shainnel O., Santos, Radleigh G., LaVoi, Travis, Nefzi, Adel, Welmaker, Greg, Giulianotti, Marc A., Toll, Lawrence
Publicado 2015

Inhibition of Aminoglycoside 6′-N-acetyltransferase Type Ib (AAC(6′)-Ib): Structure–Activity Relationship of Substituted Pyrrolidine Pentamine Derivatives as Inhibitors

por Rocha, Kenneth, Magallon, Jesus, Reeves, Craig, Phan, Kimberly, Vu, Peter, Oakley-Havens, Crista L., Kwan, Stella, Ramirez, Maria Soledad, LaVoi, Travis, Donow, Haley, Chapagain, Prem, Santos, Radleigh, Pinilla, Clemencia, Giulianotti, Marc A., Tolmasky, Marcelo E.
Publicado 2021