New Therapeutics to Treat Castrate-Resistant Prostate Cancer

por Acar, Ömer, Esen, Tarık, Lack, Nathan A.
Publicado 2013

Androgen Receptor-Mediated Transcription in Prostate Cancer

por Özturan, Doğancan, Morova, Tunç, Lack, Nathan A.
Publicado 2022

Determining the origin of synchronous multifocal bladder cancer by exome sequencing

por Acar, Ömer, Özkurt, Ezgi, Demir, Gulfem, Saraç, Hilal, Alkan, Can, Esen, Tarık, Somel, Mehmet, Lack, Nathan A.
Publicado 2015

Characterisation of a putative AraC transcriptional regulator from Mycobacterium smegmatis

por Evangelopoulos, Dimitrios, Gupta, Antima, Lack, Nathan A., Maitra, Arundhati, ten Bokum, Annemieke M.C., Kendall, Sharon, Sim, Edith, Bhakta, Sanjib
Publicado 2014

Androgen receptor-binding sites are highly mutated in prostate cancer

por Morova, Tunç, McNeill, Daniel R., Lallous, Nada, Gönen, Mehmet, Dalal, Kush, Wilson, David M., Gürsoy, Attila, Keskin, Özlem, Lack, Nathan A.
Publicado 2020

Systematic characterization of chromatin modifying enzymes identifies KDM3B as a critical regulator in castration resistant prostate cancer

por Saraç, Hilal, Morova, Tunç, Pires, Elisabete, McCullagh, James, Kaplan, Anıl, Cingöz, Ahmet, Bagci-Onder, Tugba, Önder, Tamer, Kawamura, Akane, Lack, Nathan A.
Publicado 2019

Genetic variants of MARCO are associated with susceptibility to pulmonary tuberculosis in a Gambian population

por Bowdish, Dawn ME, Sakamoto, Kaori, Lack, Nathan A, Hill, Philip C, Sirugo, Giorgio, Newport, Melanie J, Gordon, Siamon, Hill, Adrian VS, Vannberg, Fredrick O
Publicado 2013

Optimized high-throughput screening of non-coding variants identified from genome-wide association studies

por Morova, Tunc, Ding, Yi, Huang, Chia-Chi F, Sar, Funda, Schwarz, Tommer, Giambartolomei, Claudia, Baca, Sylvan C, Grishin, Dennis, Hach, Faraz, Gusev, Alexander, Freedman, Matthew L, Pasaniuc, Bogdan, Lack, Nathan A
Publicado 2022

Curcuphenol possesses an unusual histone deacetylase enhancing activity that counters immune escape in metastatic tumours

por Ellis, Samantha L. S., Dada, Sarah, Nohara, Lilian L., Saranchova, Iryna, Munro, Lonna, Pfeifer, Cheryl G., Eyford, Brett A., Morova, Tunc, Williams, David E., Cheng, Ping, Lack, Nathan A., Andersen, Raymond J., Jefferies, Wilfred A.
Publicado 2023

KDM2B, an H3K36-specific demethylase, regulates apoptotic response of GBM cells to TRAIL

por Kurt, Ibrahim Cagri, Sur, Ilknur, Kaya, Ezgi, Cingoz, Ahmet, Kazancioglu, Selena, Kahya, Zeynep, Toparlak, Omer Duhan, Senbabaoglu, Filiz, Kaya, Zeynep, Ozyerli, Ezgi, Karahüseyinoglu, Sercin, Lack, Nathan A, Gümüs, Zeynep H, Onder, Tamer T, Bagci-Onder, Tugba
Publicado 2017

Development of an Androgen Receptor Inhibitor Targeting the N-Terminal Domain of Androgen Receptor for Treatment of Castration Resistant Prostate Cancer

por Ban, Fuqiang, Leblanc, Eric, Cavga, Ayse Derya, Huang, Chia-Chi Flora, Flory, Mark R., Zhang, Fan, Chang, Matthew E. K., Morin, Hélène, Lallous, Nada, Singh, Kriti, Gleave, Martin E., Mohammed, Hisham, Rennie, Paul S., Lack, Nathan A., Cherkasov, Artem
Publicado 2021

EPIKOL, a chromatin-focused CRISPR/Cas9-based screening platform, to identify cancer-specific epigenetic vulnerabilities

por Yedier-Bayram, Ozlem, Gokbayrak, Bengul, Kayabolen, Alisan, Aksu, Ali Cenk, Cavga, Ayse Derya, Cingöz, Ahmet, Kala, Ezgi Yagmur, Karabiyik, Goktug, Günsay, Rauf, Esin, Beril, Morova, Tunc, Uyulur, Fırat, Syed, Hamzah, Philpott, Martin, Cribbs, Adam P., Kung, Sonia H. Y., Lack, Nathan A., Onder, Tamer T., Bagci-Onder, Tugba
Publicado 2022

Specific cannabinoids revive adaptive immunity by reversing immune evasion mechanisms in metastatic tumours

por Dada, Sarah, Ellis, Samantha L. S., Wood, Christi, Nohara, Lilian L., Dreier, Carola, Garcia, Nicolas H., Saranchova, Iryna, Munro, Lonna, Pfeifer, Cheryl G., Eyford, Brett A., Kari, Suresh, Garrovillas, Emmanuel, Caspani, Giorgia, Al Haddad, Eliana, Gray, Patrick W., Morova, Tunc, Lack, Nathan A., Andersen, Raymond J., Tjoelker, Larry, Jefferies, Wilfred A.
Publicado 2023

Protein Scaffold‐Based Multimerization of Soluble ACE2 Efficiently Blocks SARS‐CoV‐2 Infection In Vitro and In Vivo

por Kayabolen, Alisan, Akcan, Ugur, Özturan, Doğancan, Ulbegi‐Polat, Hivda, Sahin, Gizem Nur, Pinarbasi‐Degirmenci, Nareg, Bayraktar, Canan, Soyler, Gizem, Sarayloo, Ehsan, Nurtop, Elif, Ozer, Berna, Guney‐Esken, Gulen, Barlas, Tayfun, Yildirim, Ismail Selim, Dogan, Ozlem, Karahuseyinoglu, Sercin, Lack, Nathan A., Kaya, Mehmet, Albayrak, Cem, Can, Fusun, Solaroglu, Ihsan, Bagci‐Onder, Tugba
Publicado 2022

Epigenetic-focused CRISPR/Cas9 screen identifies (absent, small, or homeotic)2-like protein (ASH2L) as a regulator of glioblastoma cell survival

por Ozyerli-Goknar, Ezgi, Kala, Ezgi Yagmur, Aksu, Ali Cenk, Bulut, Ipek, Cingöz, Ahmet, Nizamuddin, Sheikh, Biniossek, Martin, Seker-Polat, Fidan, Morova, Tunc, Aztekin, Can, Kung, Sonia H. Y., Syed, Hamzah, Tuncbag, Nurcan, Gönen, Mehmet, Philpott, Martin, Cribbs, Adam P., Acilan, Ceyda, Lack, Nathan A., Onder, Tamer T., Timmers, H. T. Marc, Bagci-Onder, Tugba
Publicado 2023

Pathogenic mycobacteria achieve cellular persistence by inhibiting the Niemann-Pick Type C disease cellular pathway

por Fineran, Paul, Lloyd-Evans, Emyr, Lack, Nathan A., Platt, Nick, Davis, Lianne C., Morgan, Anthony J., Höglinger, Doris, Tatituri, Raju Venkata V., Clark, Simon, Williams, Ian M., Tynan, Patricia, Al Eisa, Nada, Nazarova, Evgeniya, Williams, Ann, Galione, Antony, Ory, Daniel S., Besra, Gurdyal S., Russell, David G., Brenner, Michael B., Sim, Edith, Platt, Frances M.
Publicado 2017

Genome-wide CRISPR screen identifies PRC2 and KMT2D-COMPASS as regulators of distinct EMT trajectories that contribute differentially to metastasis

por Zhang, Yun, Donaher, Joana Liu, Das, Sunny, Li, Xin, Reinhardt, Ferenc, Krall, Jordan A., Lambert, Arthur W., Thiru, Prathapan, Keys, Heather R., Khan, Mehreen, Hofree, Matan, Wilson, Molly M., Yedier-Bayram, Ozlem, Lack, Nathan A., Onder, Tamer T., Bagci-Onder, Tugba, Tyler, Michael, Tirosh, Itay, Regev, Aviv, Lees, Jacqueline A., Weinberg, Robert A.
Publicado 2022

Association of B7‐H3 expression with racial ancestry, immune cell density, and androgen receptor activation in prostate cancer

por Mendes, Adrianna A., Lu, Jiayun, Kaur, Harsimar B., Zheng, Siqun L., Xu, Jianfeng, Hicks, Jessica, Weiner, Adam B., Schaeffer, Edward M., Ross, Ashley E., Balk, Steven P., Taplin, Mary‐Ellen, Lack, Nathan A., Tekoglu, Emirhan, Maynard, Janielle P., De Marzo, Angelo M., Antonarakis, Emmanuel S., Sfanos, Karen S., Joshu, Corinne E., Shenderov, Eugene, Lotan, Tamara L.
Publicado 2022

Functional mapping of androgen receptor enhancer activity

por Huang, Chia-Chi Flora, Lingadahalli, Shreyas, Morova, Tunc, Ozturan, Dogancan, Hu, Eugene, Yu, Ivan Pak Lok, Linder, Simon, Hoogstraat, Marlous, Stelloo, Suzan, Sar, Funda, van der Poel, Henk, Altintas, Umut Berkay, Saffarzadeh, Mohammadali, Le Bihan, Stephane, McConeghy, Brian, Gokbayrak, Bengul, Feng, Felix Y., Gleave, Martin E., Bergman, Andries M., Collins, Colin, Hach, Faraz, Zwart, Wilbert, Emberly, Eldon, Lack, Nathan A.
Publicado 2021

Extensive androgen receptor enhancer heterogeneity in primary prostate cancers underlies transcriptional diversity and metastatic potential

por Kneppers, Jeroen, Severson, Tesa M., Siefert, Joseph C., Schol, Pieter, Joosten, Stacey E. P., Yu, Ivan Pak Lok, Huang, Chia-Chi Flora, Morova, Tunç, Altıntaş, Umut Berkay, Giambartolomei, Claudia, Seo, Ji-Heui, Baca, Sylvan C., Carneiro, Isa, Emberly, Eldon, Pasaniuc, Bogdan, Jerónimo, Carmen, Henrique, Rui, Freedman, Matthew L., Wessels, Lodewyk F. A., Lack, Nathan A., Bergman, Andries M., Zwart, Wilbert
Publicado 2022