Sortilin, SorCS1b, and SorLA Vps10p sorting receptors, are novel γ-secretase substrates

por Nyborg, Andrew C, Ladd, Thomas B, Zwizinski, Craig W, Lah, James J, Golde, Todd E
Publicado 2006

Designing antibodies against LRRK2-targeted tau epitopes

por Hamm, Matthew, Ladd, Thomas B., Levites, Yona, Golde, Todd E., Giasson, Benoit I., Lewis, Jada
Publicado 2018

Signal peptide peptidase (SPP) dimer formation as assessed by fluorescence lifetime imaging microscopy (FLIM) in intact cells

por Nyborg, Andrew C, Herl, Lauren, Berezovska, Oksana, Thomas, Anne V, Ladd, Thomas B, Jansen, Karen, Hyman, Bradley T, Golde, Todd E
Publicado 2006

γ-Secretase modulators exhibit selectivity for modulation of APP cleavage but inverse γ-secretase modulators do not

por Lessard, Christian B., Rodriguez, Edgardo, Ladd, Thomas B., Minter, Lisa M., Osborne, Barbara A., Miele, Lucio, Golde, Todd E., Ran, Yong
Publicado 2020

Independent Relationship between Amyloid Precursor Protein (APP) Dimerization and γ-Secretase Processivity

por Jung, Joo In, Premraj, Sasha, Cruz, Pedro E., Ladd, Thomas B., Kwak, Yewon, Koo, Edward H., Felsenstein, Kevin M., Golde, Todd E., Ran, Yong
Publicado 2014

Studies of lipopolysaccharide effects on the induction of α-synuclein pathology by exogenous fibrils in transgenic mice

por Rutherford, Nicola J., Sacino, Amanda N., Brooks, Mieu, Ceballos-Diaz, Carolina, Ladd, Thomas B., Howard, Jasie K., Golde, Todd E., Giasson, Benoit I.
Publicado 2015

Cardiac MLC2 kinase is localized to the Z-disc and interacts with α-actinin2

por X. Cai, Lawrence, Tanada, Yohei, D. Bello, Gregory, C. Fleming, James, F. Alkassis, Fariz, Ladd, Thomas, Golde, Todd, Koh, Jin, Chen, Sixue, Kasahara, Hideko
Publicado 2019

Complex Relationships between Substrate Sequence and Sensitivity to Alterations in γ-Secretase Processivity Induced by γ-Secretase Modulators

por Jung, Joo In, Ran, Yong, Cruz, Pedro E., Rosario, Awilda M., Ladd, Thomas B., Kukar, Thomas L., Koo, Edward H., Felsenstein, Kevin M., Golde, Todd E.
Publicado 2014

Overlapping profiles of Aβ peptides in the Alzheimer's disease and pathological aging brains

por Moore, Brenda D, Chakrabarty, Paramita, Levites, Yona, Kukar, Tom L, Baine, Ann-Marie, Moroni, Tina, Ladd, Thomas B, Das, Pritam, Dickson, Dennis W, Golde, Todd E
Publicado 2012

High‐affinity interactions and signal transduction between Aβ oligomers and TREM2

por Lessard, Christian B, Malnik, Samuel L, Zhou, Yingyue, Ladd, Thomas B, Cruz, Pedro E, Ran, Yong, Mahan, Thomas E, Chakrabaty, Paramita, Holtzman, David M, Ulrich, Jason D, Colonna, Marco, Golde, Todd E
Publicado 2018

Microglia show differential transcriptomic response to Aβ peptide aggregates ex vivo and in vivo

por McFarland, Karen N, Ceballos, Carolina, Rosario, Awilda, Ladd, Thomas, Moore, Brenda, Golde, Griffin, Wang, Xue, Allen, Mariet, Ertekin-Taner, Nilüfer, Funk, Cory C, Robinson, Max, Baloni, Priyanka, Rappaport, Noa, Chakrabarty, Paramita, Golde, Todd E
Publicado 2021

Cholestenoic acid, an endogenous cholesterol metabolite, is a potent γ-secretase modulator

por Jung, Joo In, Price, Ashleigh R., Ladd, Thomas B., Ran, Yong, Park, Hyo-Jin, Ceballos-Diaz, Carolina, Smithson, Lisa A., Hochhaus, Günther, Tang, Yufei, Akula, Rajender, Ba, Saritha, Koo, Edward H., Shapiro, Gideon, Felsenstein, Kevin M., Golde, Todd E.
Publicado 2015

Modulating innate immune activation states impacts the efficacy of specific Aβ immunotherapy

por Levites, Yona, Funk, Cory, Wang, Xue, Chakrabarty, Paramita, McFarland, Karen N., Bramblett, Baxter, O’Neal, Veronica, Liu, Xufei, Ladd, Thomas, Robinson, Max, Allen, Mariet, Carrasquillo, Minerva M., Dickson, Dennis, Cruz, Pedro, Ryu, Danny, Li, Hong-Dong, Price, Nathan D., Ertekin-Taner, NIlüfer, Golde, Todd E.
Publicado 2021

Short Aβ peptides attenuate Aβ42 toxicity in vivo

por Moore, Brenda D., Martin, Jason, de Mena, Lorena, Sanchez, Jonatan, Cruz, Pedro E., Ceballos-Diaz, Carolina, Ladd, Thomas B., Ran, Yong, Levites, Yona, Kukar, Thomas L., Kurian, Justin J., McKenna, Robert, Koo, Edward H., Borchelt, David R., Janus, Christopher, Rincon-Limas, Diego, Fernandez-Funez, Pedro, Golde, Todd E.
Publicado 2018

An anti-CRF antibody suppresses the HPA axis and reverses stress-induced phenotypes

por Futch, Hunter S., McFarland, Karen N., Moore, Brenda D., Kuhn, M. Zino, Giasson, Benoit I., Ladd, Thomas B., Scott, Karen A., Shapiro, Melanie R., Nosacka, Rachel L., Goodwin, Marshall S., Ran, Yong, Cruz, Pedro E., Ryu, Daniel H., Croft, Cara L., Levites, Yona, Janus, Christopher, Chakrabarty, Paramita, Judge, Andrew R., Brusko, Todd M., de Kloet, Annette D., Krause, Eric G., Golde, Todd E.
Publicado 2019

TLR5 decoy receptor as a novel anti-amyloid therapeutic for Alzheimer’s disease

por Chakrabarty, Paramita, Li, Andrew, Ladd, Thomas B., Strickland, Michael R., Koller, Emily J., Burgess, Jeremy D., Funk, Cory C., Cruz, Pedro E., Allen, Mariet, Yaroshenko, Mariya, Wang, Xue, Younkin, Curtis, Reddy, Joseph, Lohrer, Benjamin, Mehrke, Leonie, Moore, Brenda D., Liu, Xuefei, Ceballos-Diaz, Carolina, Rosario, Awilda M., Medway, Christopher, Janus, Christopher, Li, Hong-Dong, Dickson, Dennis W., Giasson, Benoit I., Price, Nathan D., Younkin, Steven G., Ertekin-Taner, Nilüfer, Golde, Todd E.
Publicado 2018