Small molecule activators of the p53 response

por Ladds, Marcus J G W, Laín, Sonia
Publicado 2019

ATG7 is a haploinsufficient repressor of tumor progression and promoter of metastasis

por Long, Jaclyn S., Kania, Elżbieta, McEwan, David G., Barthet, Valentin J. A., Brucoli, Martina, Ladds, Marcus J.G.W., Nössing, Christoph, Ryan, Kevin M.
Publicado 2022

Lipids Shape the Electron Acceptor-Binding Site of the Peripheral Membrane Protein Dihydroorotate Dehydrogenase

por Costeira-Paulo, Joana, Gault, Joseph, Popova, Gergana, Ladds, Marcus J.G.W., van Leeuwen, Ingeborg M.M., Sarr, Médoune, Olsson, Anders, Lane, David P., Laín, Sonia, Marklund, Erik G., Landreh, Michael
Publicado 2018

Exploitation of dihydroorotate dehydrogenase (DHODH) and p53 activation as therapeutic targets: A case study in polypharmacology

por Ladds, Marcus J. G.W., Popova, Gergana, Pastor-Fernández, Andrés, Kannan, Srinivasaraghavan, van Leeuwen, Ingeborg M.M., Håkansson, Maria, Walse, Björn, Tholander, Fredrik, Bhatia, Ravi, Verma, Chandra S., Lane, David P., Laín, Sonia
Publicado 2021

Autophagy suppresses the formation of hepatocyte-derived cancer-initiating ductular progenitor cells in the liver

por Barthet, Valentin J. A., Brucoli, Martina, Ladds, Marcus J. G. W., Nössing, Christoph, Kiourtis, Christos, Baudot, Alice D., O’Prey, James, Zunino, Barbara, Müller, Miryam, May, Stephanie, Nixon, Colin, Long, Jaclyn S., Bird, Thomas G., Ryan, Kevin M.
Publicado 2021

Autophagic flux blockage by accumulation of weakly basic tenovins leads to elimination of B-Raf mutant tumour cells that survive vemurafenib

por Ladds, Marcus J. G. W., Pastor-Fernández, Andrés, Popova, Gergana, van Leeuwen, Ingeborg M. M., Eng, Kai Er, Drummond, Catherine J., Johansson, Lars, Svensson, Richard, Westwood, Nicholas J., McCarthy, Anna R., Tholander, Fredrik, Popa, Mihaela, Lane, David P., McCormack, Emmet, McInerney, Gerald M., Bhatia, Ravi, Laín, Sonia
Publicado 2018

Publisher Correction: A DHODH inhibitor increases p53 synthesis and enhances tumor cell killing by p53 degradation blockage

por Ladds, Marcus J. G. W., van Leeuwen, Ingeborg M. M., Drummond, Catherine J., Chu, Su, Healy, Alan R., Popova, Gergana, Fernández, Andrés Pastor, Mollick, Tanzina, Darekar, Suhas, Sedimbi, Saikiran K., Nekulova, Marta, Sachweh, Marijke C. C., Campbell, Johanna, Higgins, Maureen, Tuck, Chloe, Popa, Mihaela, Safont, Mireia Mayoral, Gelebart, Pascal, Fandalyuk, Zinayida, Thompson, Alastair M., Svensson, Richard, Gustavsson, Anna-Lena, Johansson, Lars, Färnegårdh, Katarina, Yngve, Ulrika, Saleh, Aljona, Haraldsson, Martin, D’Hollander, Agathe C. A., Franco, Marcela, Zhao, Yan, Håkansson, Maria, Walse, Björn, Larsson, Karin, Peat, Emma M., Pelechano, Vicent, Lunec, John, Vojtesek, Borivoj, Carmena, Mar, Earnshaw, William C., McCarthy, Anna R., Westwood, Nicholas J., Arsenian-Henriksson, Marie, Lane, David P., Bhatia, Ravi, McCormack, Emmet, Laín, Sonia
Publicado 2023

A DHODH inhibitor increases p53 synthesis and enhances tumor cell killing by p53 degradation blockage

por Ladds, Marcus J. G. W., van Leeuwen, Ingeborg M. M., Drummond, Catherine J., Chu, Su, Healy, Alan R., Popova, Gergana, Pastor Fernández, Andrés, Mollick, Tanzina, Darekar, Suhas, Sedimbi, Saikiran K., Nekulova, Marta, Sachweh, Marijke C. C., Campbell, Johanna, Higgins, Maureen, Tuck, Chloe, Popa, Mihaela, Safont, Mireia Mayoral, Gelebart, Pascal, Fandalyuk, Zinayida, Thompson, Alastair M., Svensson, Richard, Gustavsson, Anna-Lena, Johansson, Lars, Färnegårdh, Katarina, Yngve, Ulrika, Saleh, Aljona, Haraldsson, Martin, D’Hollander, Agathe C. A., Franco, Marcela, Zhao, Yan, Håkansson, Maria, Walse, Björn, Larsson, Karin, Peat, Emma M., Pelechano, Vicent, Lunec, John, Vojtesek, Borivoj, Carmena, Mar, Earnshaw, William C., McCarthy, Anna R., Westwood, Nicholas J., Arsenian-Henriksson, Marie, Lane, David P., Bhatia, Ravi, McCormack, Emmet, Laín, Sonia
Publicado 2018

Publisher Correction: A DHODH inhibitor increases p53 synthesis and enhances tumor cell killing by p53 degradation blockage

por Ladds, Marcus J. G. W., van Leeuwen, Ingeborg M. M., Drummond, Catherine J., Chu, Su, Healy, Alan R., Popova, Gergana, Pastor Fernández, Andrés, Mollick, Tanzina, Darekar, Suhas, Sedimbi, Saikiran K., Nekulova, Marta, Sachweh, Marijke C. C., Campbell, Johanna, Higgins, Maureen, Tuck, Chloe, Popa, Mihaela, Safont, Mireia Mayoral, Gelebart, Pascal, Fandalyuk, Zinayida, Thompson, Alastair M., Svensson, Richard, Gustavsson, Anna-Lena, Johansson, Lars, Färnegårdh, Katarina, Yngve, Ulrika, Saleh, Aljona, Haraldsson, Martin, D’Hollander, Agathe C. A., Franco, Marcela, Zhao, Yan, Håkansson, Maria, Walse, Björn, Larsson, Karin, Peat, Emma M., Pelechano, Vicent, Lunec, John, Vojtesek, Borivoj, Carmena, Mar, Earnshaw, William C., McCarthy, Anna R., Westwood, Nicholas J., Arsenian-Henriksson, Marie, Lane, David P., Bhatia, Ravi, McCormack, Emmet, Laín, Sonia
Publicado 2018