Similar neuronal imprint and no cross-seeded fibrils in α-synuclein aggregates from MSA and Parkinson’s disease

por Laferrière, Florent, Claverol, Stéphane, Bezard, Erwan, De Giorgi, Francesca, Ichas, François
Publicado 2022

Targeting α-Synuclein for PD Therapeutics: A Pursuit on All Fronts

por Teil, Margaux, Arotcarena, Marie-Laure, Faggiani, Emilie, Laferriere, Florent, Bezard, Erwan, Dehay, Benjamin
Publicado 2020

Oligodendrocytes Prune Axons Containing α-Synuclein Aggregates In Vivo: Lewy Neurites as Precursors of Glial Cytoplasmic Inclusions in Multiple System Atrophy?

por De Nuccio, Francesco, Kashyrina, Marianna, Serinelli, Francesca, Laferrière, Florent, Lofrumento, Dario Domenico, De Giorgi, Francesca, Ichas, François
Publicado 2023

Overexpression of α-Synuclein by Oligodendrocytes in Transgenic Mice Does Not Recapitulate the Fibrillar Aggregation Seen in Multiple System Atrophy

por Laferrière, Florent, He, Xin, Zinghirino, Federica, Doudnikoff, Evelyne, Faggiani, Emilie, Meissner, Wassilios G., Bezard, Erwan, De Giorgi, Francesca, Ichas, François
Publicado 2020

Quaternary Structure of Pathological Prion Protein as a Determining Factor of Strain-Specific Prion Replication Dynamics

por Laferrière, Florent, Tixador, Philippe, Moudjou, Mohammed, Chapuis, Jérôme, Sibille, Pierre, Herzog, Laetitia, Reine, Fabienne, Jaumain, Emilie, Laude, Hubert, Rezaei, Human, Béringue, Vincent
Publicado 2013

Early stage prion assembly involves two subpopulations with different quaternary structures and a secondary templating pathway

por Igel-Egalon, Angélique, Laferrière, Florent, Moudjou, Mohammed, Bohl, Jan, Mezache, Mathieu, Knäpple, Tina, Herzog, Laetitia, Reine, Fabienne, Jas-Duval, Christelle, Doumic, Marie, Rezaei, Human, Béringue, Vincent
Publicado 2019

Highly Infectious Prions Generated by a Single Round of Microplate-Based Protein Misfolding Cyclic Amplification

por Moudjou, Mohammed, Sibille, Pierre, Fichet, Guillaume, Reine, Fabienne, Chapuis, Jérôme, Herzog, Laetitia, Jaumain, Emilie, Laferrière, Florent, Richard, Charles-Adrien, Laude, Hubert, Andréoletti, Olivier, Rezaei, Human, Béringue, Vincent
Publicado 2013

Functional and dynamic polymerization of the ALS-linked protein TDP-43 antagonizes its pathologic aggregation

por Afroz, Tariq, Hock, Eva-Maria, Ernst, Patrick, Foglieni, Chiara, Jambeau, Melanie, Gilhespy, Larissa A. B., Laferriere, Florent, Maniecka, Zuzanna, Plückthun, Andreas, Mittl, Peer, Paganetti, Paolo, Allain, Frédéric H. T., Polymenidou, Magdalini
Publicado 2017

Protease resistance of infectious prions is suppressed by removal of a single atom in the cellular prion protein

por Leske, Henning, Hornemann, Simone, Herrmann, Uli Simon, Zhu, Caihong, Dametto, Paolo, Li, Bei, Laferriere, Florent, Polymenidou, Magdalini, Pelczar, Pawel, Reimann, Regina Rose, Schwarz, Petra, Rushing, Elisabeth Jane, Wüthrich, Kurt, Aguzzi, Adriano
Publicado 2017

Neurons with Cat’s Eyes: A Synthetic Strain of α-Synuclein Fibrils Seeding Neuronal Intranuclear Inclusions

por De Giorgi, Francesca, Abdul-Shukkoor, Muhammed Bilal, Kashyrina, Marianna, Largitte, Leslie-Ann, De Nuccio, Francesco, Kauffmann, Brice, Lends, Alons, Laferrière, Florent, Bonhommeau, Sébastien, Lofrumento, Dario Domenico, Bousset, Luc, Bezard, Erwan, Buffeteau, Thierry, Loquet, Antoine, Ichas, François
Publicado 2022

Novel self-replicating α-synuclein polymorphs that escape ThT monitoring can spontaneously emerge and acutely spread in neurons

por De Giorgi, Francesca, Laferrière, Florent, Zinghirino, Federica, Faggiani, Emilie, Lends, Alons, Bertoni, Mathilde, Yu, Xuan, Grélard, Axelle, Morvan, Estelle, Habenstein, Birgit, Dutheil, Nathalie, Doudnikoff, Evelyne, Daniel, Jonathan, Claverol, Stéphane, Qin, Chuan, Loquet, Antoine, Bezard, Erwan, Ichas, François
Publicado 2020