Discovery of Highly Trimethoprim-Resistant DfrB Dihydrofolate Reductases in Diverse Environmental Settings Suggests an Evolutionary Advantage Unrelated to Antibiotic Resistance

por Cellier-Goetghebeur, Stella, Lafontaine, Kiana, Lemay-St-Denis, Claudèle, Tsamo, Princesse, Bonneau-Burke, Alexis, Copp, Janine N., Pelletier, Joelle N.
Publicado 2022

Epistasis between promoter activity and coding mutations shapes gene evolvability

por Cisneros, Angel F., Gagnon-Arsenault, Isabelle, Dubé, Alexandre K., Després, Philippe C., Kumar, Pradum, Lafontaine, Kiana, Pelletier, Joelle N., Landry, Christian R.
Publicado 2023

A conserved SH3-like fold in diverse putative proteins tetramerizes into an oxidoreductase providing an antimicrobial resistance phenotype

por Lemay-St-Denis, Claudèle, Alejaldre, Lorea, Jemouai, Zakaria, Lafontaine, Kiana, St-Aubin, Maxime, Hitache, Katia, Valikhani, Donya, Weerasinghe, Nuwani W., Létourneau, Myriam, Thibodeaux, Christopher J., Doucet, Nicolas, Baron, Christian, Copp, Janine N., Pelletier, Joelle N.
Publicado 2023