In Vitro Resistance Selections for Plasmodium falciparum Dihydroorotate Dehydrogenase Inhibitors Give Mutants with Multiple Point Mutations in the Drug-binding Site and Altered Gro...

por Ross, Leila S., Gamo, Francisco Javier, Lafuente-Monasterio, Maria José, Singh, Onkar M. P., Rowland, Paul, Wiegand, Roger C., Wirth, Dyann F.
Publicado 2014

Identification of Collateral Sensitivity to Dihydroorotate Dehydrogenase Inhibitors in Plasmodium falciparum

por Ross, Leila Saxby, Lafuente-Monasterio, Maria José, Sakata-Kato, Tomoyo, Mandt, Rebecca E. K., Gamo, Francisco Javier, Wirth, Dyann F., Lukens, Amanda K.
Publicado 2018

Identification of Plasmodium PI4 kinase as target of MMV390048 by chemoproteomics

por Ghidelli-Disse, Sonja, Lafuente-Monasterio, Maria Jose, Waterson, David, Witty, Michael, Younis, Yassir, Paquet, Tanya, Street, Leslie J, Chibale, Kelly, Gamo-Benito, Francisco Javier, Bantscheff, Marcus, Drewes, Gerard
Publicado 2014

Diverse evolutionary pathways challenge the use of collateral sensitivity as a strategy to suppress resistance

por Mandt, Rebecca EK, Luth, Madeline R, Tye, Mark A, Mazitschek, Ralph, Ottilie, Sabine, Winzeler, Elizabeth A, Lafuente-Monasterio, Maria Jose, Gamo, Francisco Javier, Wirth, Dyann F, Lukens, Amanda K
Publicado 2023

Disruption of the Plasmodium falciparum Life Cycle through Transcriptional Reprogramming by Inhibitors of Jumonji Demethylases

por Matthews, Krista A., Senagbe, Kossi M., Nötzel, Christopher, Gonzales, Christopher A., Tong, Xinran, Rijo-Ferreira, Filipa, Bhanu, Natarajan V., Miguel-Blanco, Celia, Lafuente-Monasterio, Maria Jose, Garcia, Benjamin A., Kafsack, Björn F. C., Martinez, Elisabeth D.
Publicado 2020

Development of an ectopic huLiver model for Plasmodium liver stage infection

por Samayoa-Reyes, Gabriela, Flaherty, Siobhan M., Wickham, Kristina S., Viera-Morilla, Sara, Strauch, Pamela M., Roth, Alison, Padrón, Laura, Jackson, Conner M., Meireles, Patricia, Calvo, David, Roobsoong, Wanlapa, Kangwanrangsan, Niwat, Sattabongkot, Jetsumon, Reichard, Gregory, Lafuente-Monasterio, Maria José, Rochford, Rosemary
Publicado 2023

Isoxazolopyrimidine-Based Inhibitors of Plasmodium falciparum Dihydroorotate Dehydrogenase with Antimalarial Activity

por Kokkonda, Sreekanth, El Mazouni, Farah, White, Karen L., White, John, Shackleford, David M., Lafuente-Monasterio, Maria Jose, Rowland, Paul, Manjalanagara, Krishne, Joseph, Jayan T., Garcia-Pérez, Adolfo, Fernandez, Jorge, Gamo, Francisco Javier, Waterson, David, Burrows, Jeremy N., Palmer, Michael J., Charman, Susan A., Rathod, Pradipsinh K., Phillips, Margaret A.
Publicado 2018

A potent antimalarial benzoxaborole targets a Plasmodium falciparum cleavage and polyadenylation specificity factor homologue

por Sonoiki, Ebere, Ng, Caroline L., Lee, Marcus C. S., Guo, Denghui, Zhang, Yong-Kang, Zhou, Yasheen, Alley, M. R. K., Ahyong, Vida, Sanz, Laura M., Lafuente-Monasterio, Maria Jose, Dong, Chen, Schupp, Patrick G., Gut, Jiri, Legac, Jenny, Cooper, Roland A., Gamo, Francisco-Javier, DeRisi, Joseph, Freund, Yvonne R., Fidock, David A., Rosenthal, Philip J.
Publicado 2017

Biochemical Screening of Five Protein Kinases from Plasmodium falciparum against 14,000 Cell-Active Compounds

por Crowther, Gregory J., Hillesland, Heidi K., Keyloun, Katelyn R., Reid, Molly C., Lafuente-Monasterio, Maria Jose, Ghidelli-Disse, Sonja, Leonard, Stephen E., He, Panqing, Jones, Jackson C., Krahn, Mallory M., Mo, Jack S., Dasari, Kartheek S., Fox, Anna M. W., Boesche, Markus, El Bakkouri, Majida, Rivas, Kasey L., Leroy, Didier, Hui, Raymond, Drewes, Gerard, Maly, Dustin J., Van Voorhis, Wesley C., Ojo, Kayode K.
Publicado 2016

A broad analysis of resistance development in the malaria parasite

por Corey, Victoria C., Lukens, Amanda K., Istvan, Eva S., Lee, Marcus C. S., Franco, Virginia, Magistrado, Pamela, Coburn-Flynn, Olivia, Sakata-Kato, Tomoyo, Fuchs, Olivia, Gnädig, Nina F., Goldgof, Greg, Linares, Maria, Gomez-Lorenzo, Maria G., De Cózar, Cristina, Lafuente-Monasterio, Maria Jose, Prats, Sara, Meister, Stephan, Tanaseichuk, Olga, Wree, Melanie, Zhou, Yingyao, Willis, Paul A., Gamo, Francisco-Javier, Goldberg, Daniel E., Fidock, David A., Wirth, Dyann F., Winzeler, Elizabeth A.
Publicado 2016

Novel Antitubercular 6-Dialkylaminopyrimidine Carboxamides from Phenotypic Whole-Cell High Throughput Screening of a SoftFocus Library: Structure–Activity Relationship and Target I...

por Wilson, Colin R., Gessner, Richard K., Moosa, Atica, Seldon, Ronnett, Warner, Digby F., Mizrahi, Valerie, Soares de Melo, Candice, Simelane, Sandile B., Nchinda, Aloysius, Abay, Efrem, Taylor, Dale, Njoroge, Mathew, Brunschwig, Christel, Lawrence, Nina, Boshoff, Helena I. M., Barry, Clifton E., Sirgel, Frederick A., van Helden, Paul, Harris, C. John, Gordon, Richard, Ghidelli-Disse, Sonja, Pflaumer, Hannah, Boesche, Markus, Drewes, Gerard, Sanz, Olalla, Santos, Gracia, Rebollo-Lopez, Maria José, Urones, Beatriz, Selenski, Carolyn, Lafuente-Monasterio, Maria Jose, Axtman, Matthew, Lelièvre, Joël, Ballell, Lluis, Mueller, Rudolf, Street, Leslie J., Ghorpade, Sandeep R., Chibale, Kelly
Publicado 2017

Setting Our Sights on Infectious Diseases

por De Rycker, Manu, Horn, David, Aldridge, Bree, Amewu, Richard K., Barry, Clifton E., Buckner, Frederick S., Cook, Sarah, Ferguson, Michael A. J., Gobeau, Nathalie, Herrmann, Jennifer, Herrling, Paul, Hope, William, Keiser, Jennifer, Lafuente-Monasterio, Maria Jose, Leeson, Paul D., Leroy, Didier, Manjunatha, Ujjini H., McCarthy, James, Miles, Timothy J., Mizrahi, Valerie, Moshynets, Olena, Niles, Jacquin, Overington, John P., Pottage, John, Rao, Srinivasa P. S., Read, Kevin D., Ribeiro, Isabela, Silver, Lynn L., Southern, Jen, Spangenberg, Thomas, Sundar, Shyam, Taylor, Caitlin, Van Voorhis, Wes, White, Nicholas J., Wyllie, Susan, Wyatt, Paul G., Gilbert, Ian H.
Publicado 2019