Combining fatty acid amide hydrolase (FAAH) inhibition with peroxisome proliferator-activated receptor (PPAR) activation: a new potential multi-target therapeutic strategy for the...

por Brunetti, Leonardo, Laghezza, Antonio, Loiodice, Fulvio, Tortorella, Paolo, Piemontese, Luca
Publicado 2019

Beyond the Canonical Endocannabinoid System. A Screening of PPAR Ligands as FAAH Inhibitors

por Brunetti, Leonardo, Carrieri, Antonio, Piemontese, Luca, Tortorella, Paolo, Loiodice, Fulvio, Laghezza, Antonio
Publicado 2020

Natural Compounds for the Prevention and Treatment of Cardiovascular and Neurodegenerative Diseases

por Leuci, Rosalba, Brunetti, Leonardo, Poliseno, Viviana, Laghezza, Antonio, Loiodice, Fulvio, Tortorella, Paolo, Piemontese, Luca
Publicado 2020

(2-Aminobenzothiazole)-Methyl-1,1-Bisphosphonic Acids: Targeting Matrix Metalloproteinase 13 Inhibition to the Bone

por Laghezza, Antonio, Piemontese, Luca, Brunetti, Leonardo, Caradonna, Alessia, Agamennone, Mariangela, Loiodice, Fulvio, Tortorella, Paolo
Publicado 2021

Insights into the Complex Formed by Matrix Metalloproteinase-2 and Alloxan Inhibitors: Molecular Dynamics Simulations and Free Energy Calculations

por Giangreco, Ilenia, Lattanzi, Gianluca, Nicolotti, Orazio, Catto, Marco, Laghezza, Antonio, Leonetti, Francesco, Stefanachi, Angela, Carotti, Angelo
Publicado 2011

Screening of saponins and sapogenins from Medicago species as potential PPARγ agonists and X-ray structure of the complex PPARγ/caulophyllogenin

por Montanari, Roberta, Capelli, Davide, Tava, Aldo, Galli, Andrea, Laghezza, Antonio, Tortorella, Paolo, Loiodice, Fulvio, Pochetti, Giorgio
Publicado 2016

Seeking for Non-Zinc-Binding MMP-2 Inhibitors: Synthesis, Biological Evaluation and Molecular Modelling Studies

por Ammazzalorso, Alessandra, De Filippis, Barbara, Campestre, Cristina, Laghezza, Antonio, Marrone, Alessandro, Amoroso, Rosa, Tortorella, Paolo, Agamennone, Mariangela
Publicado 2016

Structural basis for PPAR partial or full activation revealed by a novel ligand binding mode

por Capelli, Davide, Cerchia, Carmen, Montanari, Roberta, Loiodice, Fulvio, Tortorella, Paolo, Laghezza, Antonio, Cervoni, Laura, Pochetti, Giorgio, Lavecchia, Antonio
Publicado 2016

Dual targeting of cancer-related human matrix metalloproteinases and carbonic anhydrases by chiral N-(biarylsulfonyl)-phosphonic acids

por Luisi, Grazia, Angelini, Guido, Gasbarri, Carla, Laghezza, Antonio, Agamennone, Mariangela, Loiodice, Fulvio, Supuran, Claudiu T., Campestre, Cristina, Tortorella, Paolo
Publicado 2017

A New Series of Aryloxyacetic Acids Endowed with Multi-Target Activity towards Peroxisome Proliferator-Activated Receptors (PPARs), Fatty Acid Amide Hydrolase (FAAH), and Acetylcho...

por Leuci, Rosalba, Brunetti, Leonardo, Laghezza, Antonio, Piemontese, Luca, Carrieri, Antonio, Pisani, Leonardo, Tortorella, Paolo, Catto, Marco, Loiodice, Fulvio
Publicado 2022

Natural Scaffolds with Multi-Target Activity for the Potential Treatment of Alzheimer’s Disease

por Piemontese, Luca, Vitucci, Gabriele, Catto, Marco, Laghezza, Antonio, Perna, Filippo Maria, Rullo, Mariagrazia, Loiodice, Fulvio, Capriati, Vito, Solfrizzo, Michele
Publicado 2018

Biological Screening and Crystallographic Studies of Hydroxy γ-Lactone Derivatives to Investigate PPARγ Phosphorylation Inhibition

por Capelli, Davide, Cazzaniga, Giulia, Mori, Matteo, Laghezza, Antonio, Loiodice, Fulvio, Quaglia, Martina, Negro, Elisa, Meneghetti, Fiorella, Villa, Stefania, Montanari, Roberta
Publicado 2023

Single-Nucleotide Polymorphism of PPARγ, a Protein at the Crossroads of Physiological and Pathological Processes

por Petrosino, Maria, Lori, Laura, Pasquo, Alessandra, Lori, Clorinda, Consalvi, Valerio, Minicozzi, Velia, Morante, Silvia, Laghezza, Antonio, Giorgi, Alessandra, Capelli, Davide, Chiaraluce, Roberta
Publicado 2017

Betulinic acid is a PPARγ antagonist that improves glucose uptake, promotes osteogenesis and inhibits adipogenesis

por Brusotti, Gloria, Montanari, Roberta, Capelli, Davide, Cattaneo, Giulia, Laghezza, Antonio, Tortorella, Paolo, Loiodice, Fulvio, Peiretti, Franck, Bonardo, Bernadette, Paiardini, Alessandro, Calleri, Enrica, Pochetti, Giorgio
Publicado 2017

Bone-Seeking Matrix Metalloproteinase Inhibitors for the Treatment of Skeletal Malignancy

por Laghezza, Antonio, Piemontese, Luca, Brunetti, Leonardo, Caradonna, Alessia, Agamennone, Mariangela, Di Pizio, Antonella, Pochetti, Giorgio, Montanari, Roberta, Capelli, Davide, Tauro, Marilena, Loiodice, Fulvio, Tortorella, Paolo
Publicado 2020

Derivatives of Tenuazonic Acid as Potential New Multi-Target Anti-Alzheimer’s Disease Agents

por Poliseno, Viviana, Chaves, Sílvia, Brunetti, Leonardo, Loiodice, Fulvio, Carrieri, Antonio, Laghezza, Antonio, Tortorella, Paolo, Magalhães, João D., Cardoso, Sandra M., Santos, M. Amélia, Piemontese, Luca
Publicado 2021

Novel Benzylidene Thiazolidinedione Derivatives as Partial PPARγ Agonists and their Antidiabetic Effects on Type 2 Diabetes

por Yasmin, Sabina, Capone, Fabio, Laghezza, Antonio, Piaz, Fabrizio Dal, Loiodice, Fulvio, Vijayan, Viswanathan, Devadasan, Velmurugan, Mondal, Susanta K., Atlı, Özlem, Baysal, Merve, Pattnaik, Ashok K., Jayaprakash, Venkatesan, Lavecchia, Antonio
Publicado 2017

Novel Phenothiazine/Donepezil-like Hybrids Endowed with Antioxidant Activity for a Multi-Target Approach to the Therapy of Alzheimer’s Disease

por Carocci, Alessia, Barbarossa, Alexia, Leuci, Rosalba, Carrieri, Antonio, Brunetti, Leonardo, Laghezza, Antonio, Catto, Marco, Limongelli, Francesco, Chaves, Sílvia, Tortorella, Paolo, Altomare, Cosimo Damiano, Santos, Maria Amélia, Loiodice, Fulvio, Piemontese, Luca
Publicado 2022

Sulfonimide and Amide Derivatives as Novel PPARα Antagonists: Synthesis, Antiproliferative Activity, and Docking Studies

por Ammazzalorso, Alessandra, Bruno, Isabella, Florio, Rosalba, De Lellis, Laura, Laghezza, Antonio, Cerchia, Carmen, De Filippis, Barbara, Fantacuzzi, Marialuigia, Giampietro, Letizia, Maccallini, Cristina, Tortorella, Paolo, Veschi, Serena, Loiodice, Fulvio, Lavecchia, Antonio, Cama, Alessandro, Amoroso, Rosa
Publicado 2020