Telomere dysfunction promotes cholangiocyte senescence and biliary fibrosis in primary sclerosing cholangitis

por Jalan-Sakrikar, Nidhi, Anwar, Abid, Yaqoob, Usman, Gan, Can, Lagnado, Anthony B., Wixom, Alexander Q., Jurk, Diana, Huebert, Robert C.
Publicado 2023

A chronic wound model to investigate skin cellular senescence

por Wyles, Saranya P., Dashti, Parisa, Pirtskhalava, Tamar, Tekin, Burak, Inman, Christina, Gomez, Lilian Sales, Lagnado, Anthony B., Prata, Larissa, Jurk, Diana, Passos, João F., Tchkonia, Tamar, Kirkland, James L.
Publicado 2023

Cytoplasmic innate immune sensing by the caspase-4 non-canonical inflammasome promotes cellular senescence

por Fernández-Duran, Irene, Quintanilla, Andrea, Tarrats, Núria, Birch, Jodie, Hari, Priya, Millar, Fraser R., Lagnado, Anthony B., Smer-Barreto, Vanessa, Muir, Morwenna, Brunton, Valerie G., Passos, João F., Acosta, Juan Carlos
Publicado 2021

Rapamycin improves healthspan but not inflammaging in nfκb1 (−/−) mice

por Correia‐Melo, Clara, Birch, Jodie, Fielder, Edward, Rahmatika, Dina, Taylor, Jennifer, Chapman, James, Lagnado, Anthony, Carroll, Bernadette M., Miwa, Satomi, Richardson, Gavin, Jurk, Diana, Oakley, Fiona, Mann, Jelena, Mann, Derek A., Korolchuk, Viktor I., Passos, João F.
Publicado 2018

Targeted clearance of p21‐ but not p16‐positive senescent cells prevents radiation‐induced osteoporosis and increased marrow adiposity

por Chandra, Abhishek, Lagnado, Anthony B., Farr, Joshua N., Doolittle, Madison, Tchkonia, Tamara, Kirkland, James L., LeBrasseur, Nathan K., Robbins, Paul D., Niedernhofer, Laura J., Ikeno, Yuji, Passos, João F., Monroe, David G., Pignolo, Robert J., Khosla, Sundeep
Publicado 2022

Temporal inhibition of autophagy reveals segmental reversal of ageing with increased cancer risk

por Cassidy, Liam D., Young, Andrew R. J., Young, Christopher N. J., Soilleux, Elizabeth J., Fielder, Edward, Weigand, Bettina M., Lagnado, Anthony, Brais, Rebecca, Ktistakis, Nicholas T., Wiggins, Kimberley A., Pyrillou, Katerina, Clarke, Murray C. H., Jurk, Diana, Passos, Joao F., Narita, Masashi
Publicado 2020

Mitochondria-to-nucleus retrograde signaling drives formation of cytoplasmic chromatin and inflammation in senescence

por Vizioli, Maria Grazia, Liu, Tianhui, Miller, Karl N., Robertson, Neil A., Gilroy, Kathryn, Lagnado, Anthony B., Perez-Garcia, Arantxa, Kiourtis, Christos, Dasgupta, Nirmalya, Lei, Xue, Kruger, Patrick J., Nixon, Colin, Clark, William, Jurk, Diana, Bird, Thomas G., Passos, João F., Berger, Shelley L., Dou, Zhixun, Adams, Peter D.
Publicado 2020

Local senolysis in aged mice only partially replicates the benefits of systemic senolysis

por Farr, Joshua N., Saul, Dominik, Doolittle, Madison L., Kaur, Japneet, Rowsey, Jennifer L., Vos, Stephanie J., Froemming, Mitchell N., Lagnado, Anthony B., Zhu, Yi, Weivoda, Megan, Ikeno, Yuji, Pignolo, Robert J., Niedernhofer, Laura J., Robbins, Paul D., Jurk, Diana, Passos, João F., LeBrasseur, Nathan K., Tchkonia, Tamara, Kirkland, James L., Monroe, David G., Khosla, Sundeep
Publicado 2023

Length‐independent telomere damage drives post‐mitotic cardiomyocyte senescence

por Anderson, Rhys, Lagnado, Anthony, Maggiorani, Damien, Walaszczyk, Anna, Dookun, Emily, Chapman, James, Birch, Jodie, Salmonowicz, Hanna, Ogrodnik, Mikolaj, Jurk, Diana, Proctor, Carole, Correia‐Melo, Clara, Victorelli, Stella, Fielder, Edward, Berlinguer‐Palmini, Rolando, Owens, Andrew, Greaves, Laura C, Kolsky, Kathy L, Parini, Angelo, Douin‐Echinard, Victorine, LeBrasseur, Nathan K, Arthur, Helen M, Tual‐Chalot, Simon, Schafer, Marissa J, Roos, Carolyn M, Miller, Jordan D, Robertson, Neil, Mann, Jelena, Adams, Peter D, Tchkonia, Tamara, Kirkland, James L, Mialet‐Perez, Jeanne, Richardson, Gavin D, Passos, João F
Publicado 2019

Neutrophils induce paracrine telomere dysfunction and senescence in ROS‐dependent manner

por Lagnado, Anthony, Leslie, Jack, Ruchaud‐Sparagano, Marie‐Helene, Victorelli, Stella, Hirsova, Petra, Ogrodnik, Mikolaj, Collins, Amy L, Vizioli, Maria Grazia, Habiballa, Leena, Saretzki, Gabriele, Evans, Shane A, Salmonowicz, Hanna, Hruby, Adam, Geh, Daniel, Pavelko, Kevin D, Dolan, David, Reeves, Helen L, Grellscheid, Sushma, Wilson, Colin H, Pandanaboyana, Sanjay, Doolittle, Madison, von Zglinicki, Thomas, Oakley, Fiona, Gallage, Suchira, Wilson, Caroline L, Birch, Jodie, Carroll, Bernadette, Chapman, James, Heikenwalder, Mathias, Neretti, Nicola, Khosla, Sundeep, Masuda, Claudio Akio, Tchkonia, Tamar, Kirkland, James L, Jurk, Diana, Mann, Derek A, Passos, João F
Publicado 2021

Apoptotic stress causes mtDNA release during senescence and drives the SASP

por Victorelli, Stella, Salmonowicz, Hanna, Chapman, James, Martini, Helene, Vizioli, Maria Grazia, Riley, Joel S., Cloix, Catherine, Hall-Younger, Ella, Machado Espindola-Netto, Jair, Jurk, Diana, Lagnado, Anthony B., Sales Gomez, Lilian, Farr, Joshua N., Saul, Dominik, Reed, Rebecca, Kelly, George, Eppard, Madeline, Greaves, Laura C., Dou, Zhixun, Pirius, Nicholas, Szczepanowska, Karolina, Porritt, Rebecca A., Huang, Huijie, Huang, Timothy Y., Mann, Derek A., Masuda, Claudio Akio, Khosla, Sundeep, Dai, Haiming, Kaufmann, Scott H., Zacharioudakis, Emmanouil, Gavathiotis, Evripidis, LeBrasseur, Nathan K., Lei, Xue, Sainz, Alva G., Korolchuk, Viktor I., Adams, Peter D., Shadel, Gerald S., Tait, Stephen W. G., Passos, João F.
Publicado 2023

Senolytics decrease senescent cells in humans: Preliminary report from a clinical trial of Dasatinib plus Quercetin in individuals with diabetic kidney disease

por Hickson, LaTonya J., Langhi Prata, Larissa G.P., Bobart, Shane A., Evans, Tamara K., Giorgadze, Nino, Hashmi, Shahrukh K., Herrmann, Sandra M., Jensen, Michael D., Jia, Qingyi, Jordan, Kyra L., Kellogg, Todd A., Khosla, Sundeep, Koerber, Daniel M., Lagnado, Anthony B., Lawson, Donna K., LeBrasseur, Nathan K., Lerman, Lilach O., McDonald, Kathleen M., McKenzie, Travis J., Passos, João F., Pignolo, Robert J., Pirtskhalava, Tamar, Saadiq, Ishran M., Schaefer, Kalli K., Textor, Stephen C., Victorelli, Stella G., Volkman, Tammie L., Xue, Ailing, Wentworth, Mark A., Wissler Gerdes, Erin O., Zhu, Yi, Tchkonia, Tamara, Kirkland, James L.
Publicado 2019

Corrigendum to ‘Senolytics decrease senescent cells in humans: Preliminary report from a clinical trial of Dasatinib plus Quercetin in individuals with diabetic kidney disease’ EBi...

por Hickson, LaTonya J., Langhi Prata, Larissa G.P., Bobart, Shane A., Evans, Tamara K., Giorgadze, Nino, Hashmi, Shahrukh K., Herrmann, Sandra M., Jensen, Michael D., Jia, Qingyi, Jordan, Kyra L., Kellogg, Todd A., Khosla, Sundeep, Koerber, Daniel M., Lagnado, Anthony B., Lawson, Donna K., LeBrasseur, Nathan K., Lerman, Lilach O., McDonald, Kathleen M., McKenzie, Travis J., Passos, João F., Pignolo, Robert J., Pirtskhalava, Tamar, Saadiq, Ishran M., Schaefer, Kalli K., Textor, Stephen C., Victorelli, Stella G., Volkman, Tammie L., Xue, Ailing, Wentworth, Mark A., Wissler Gerdes, Erin O., Allison, David B., Dickinson, Stephanie L., Ejima, Keisuke, Atkinson, Elizabeth J., Lenburg, Marc, Zhu, Yi, Tchkonia, Tamara, Kirkland, James L.
Publicado 2020