Human-induced pluripotent stem cell-derived cardiomyocytes have limited I(Ks) for repolarization reserve as revealed by specific KCNQ1/KCNE1 blocker

por Zeng, Haoyu, Wang, Jixin, Clouse, Holly, Lagrutta, Armando, Sannajust, Frederick
Publicado 2019

FRESH™ 3D bioprinted cardiac tissue, a bioengineered platform for in vitro pharmacology

por Finkel, Samuel, Sweet, Shannon, Locke, Tyler, Smith, Sydney, Wang, Zhefan, Sandini, Christopher, Imredy, John, He, Yufang, Durante, Marc, Lagrutta, Armando, Feinberg, Adam, Lee, Andrew
Publicado 2023

Cardiac drug-drug interaction between HCV-NS5B pronucleotide inhibitors and amiodarone is determined by their specific diastereochemistry

por Lagrutta, Armando, Regan, Christopher P., Zeng, Haoyu, Imredy, John P., Koeplinger, Kenneth, Morissette, Pierre, Liu, Liping, Wollenberg, Gordon, Brynczka, Christopher, Lebrón, José, DeGeorge, Joseph, Sannajust, Frederick
Publicado 2017

Preclinical pharmacology and pharmacokinetics of CERC‐301, a GluN2B‐selective N‐methyl‐D‐aspartate receptor antagonist

por Garner, Rachel, Gopalakrishnan, Shobha, McCauley, John A., Bednar, Rodney A., Gaul, Stanley L., Mosser, Scott D., Kiss, Laszlo, Lynch, Joseph J., Patel, Shil, Fandozzi, Christine, Lagrutta, Armando, Briscoe, Richard, Liverton, Nigel J., Paterson, Blake M., Vornov, James J., Mazhari, Reza
Publicado 2015

Time for a Fully Integrated Nonclinical–Clinical Risk Assessment to Streamline QT Prolongation Liability Determinations: A Pharma Industry Perspective

por Vargas, Hugo M., Rolf, Michael G., Wisialowski, Todd A., Achanzar, William, Bahinski, Anthony, Bass, Alan, Benson, Charles T, Chaudhary, Khuram W., Couvreur, Nicolas, Dota, Corina, Engwall, Michael J, Michael Foley, C., Gallacher, David, Greiter‐Wilke, Andrea, Guillon, Jean‐Michel, Guth, Brian, Himmel, Herbert M., Hegele‐Hartung, Christa, Ito, Maki, Jenkinson, Stephen, Chiba, Katsuyoshi, Lagrutta, Armando, Levesque, Paul, Martel, Eric, Okai, Yoshiko, Peri, Ravikumar, Pointon, Amy, Qu, Yusheng, Teisman, Ard, Traebert, Martin, Yoshinaga, Takashi, Gintant, Gary A., Leishman, Derek J., Valentin, Jean‐Pierre
Publicado 2020