New developments in Huntington’s disease and other triplet repeat diseases: DNA repair turns to the dark side

por Lahue, Robert S.
Publicado 2020

CAG·CTG repeat instability in cultured human astrocytes

por Farrell, Brian T., Lahue, Robert S.
Publicado 2006

Rapid unwinding of triplet repeat hairpins by Srs2 helicase of Saccharomyces cerevisiae

por Dhar, Alok, Lahue, Robert S.
Publicado 2008

Histone deacetylase complexes as caretakers of genome stability

por Lahue, Robert, Frizzell, Aisling
Publicado 2012

The 26S proteasome drives trinucleotide repeat expansions

por Concannon, Claire, Lahue, Robert S.
Publicado 2013

Mechanistic features of CAG•CTG repeat contractions in cultured cells revealed by a novel genetic assay

por Pelletier, Richard, Farrell, Brian T., Miret, Juan José, Lahue, Robert S.
Publicado 2005

MutSβ and histone deacetylase complexes promote expansions of trinucleotide repeats in human cells

por Gannon, Anne-Marie M., Frizzell, Aisling, Healy, Evan, Lahue, Robert S.
Publicado 2012

A selective inhibitor of histone deacetylase 3 prevents cognitive deficits and suppresses striatal CAG repeat expansions in Huntington’s disease mice

por Suelves, Nuria, Kirkham-McCarthy, Lucy, Lahue, Robert S., Ginés, Silvia
Publicado 2017

MutSβ abundance and Msh3 ATP hydrolysis activity are important drivers of CTG•CAG repeat expansions

por Keogh, Norma, Chan, Kara Y., Li, Guo-Min, Lahue, Robert S.
Publicado 2017

Partial reconstitution of DNA large loop repair with purified proteins from Saccharomyces cerevisiae

por Sommer, Debbie, Stith, Carrie M., Burgers, Peter M. J., Lahue, Robert S.
Publicado 2008

Trinucleotide repeat expansions catalyzed by human cell-free extracts

por Stevens, Jennifer R, Lahue, Elaine E, Li, Guo-Min, Lahue, Robert S
Publicado 2013

Histone Deacetylase Complexes Promote Trinucleotide Repeat Expansions

por Debacker, Kim, Frizzell, Aisling, Gleeson, Olive, Kirkham-McCarthy, Lucy, Mertz, Tony, Lahue, Robert S.
Publicado 2012

New Functions of Ctf18-RFC in Preserving Genome Stability outside Its Role in Sister Chromatid Cohesion

por Gellon, Lionel, Razidlo, David F., Gleeson, Olive, Verra, Lauren, Schulz, Danae, Lahue, Robert S., Freudenreich, Catherine H.
Publicado 2011

Anc1, a Protein Associated with Multiple Transcription Complexes, Is Involved in Postreplication Repair Pathway in S. cerevisiae

por Erlich, Rachel L., Fry, Rebecca C., Begley, Thomas J., Daee, Danielle L., Lahue, Robert S., Samson, Leona D.
Publicado 2008

RTEL1 Inhibits Trinucleotide Repeat Expansions and Fragility

por Frizzell, Aisling, Nguyen, Jennifer H.G., Petalcorin, Mark I.R., Turner, Katherine D., Boulton, Simon J., Freudenreich, Catherine H., Lahue, Robert S.
Publicado 2014

HDAC3 deacetylates the DNA mismatch repair factor MutSβ to stimulate triplet repeat expansions

por Williams, Gregory M., Paschalis, Vasileios, Ortega, Janice, Muskett, Frederick W., Hodgkinson, James T., Li, Guo-Min, Schwabe, John W. R., Lahue, Robert S.
Publicado 2020