Chemical and Structural Aspects of Ebola Virus Entry Inhibitors

por Nyakatura, Elisabeth K., Frei, Julia C., Lai, Jonathan R.
Publicado 2014

Designed protein mimics of the Ebola virus glycoprotein GP2 α-helical bundle: Stability and pH effects

por Harrison, Joseph S, Higgins, Chelsea D, Chandran, Kartik, Lai, Jonathan R
Publicado 2011

Side chain requirements for affinity and specificity in D5, an HIV-1 antibody derived from the V(H)1-69 germline segment

por Stewart, Alex, Harrison, Joseph S, Regula, Lauren K, Lai, Jonathan R
Publicado 2013

Conformational and lipid bilayer-perturbing properties of Marburg virus GP2 segments containing the fusion loop and membrane-proximal external region/transmembrane domain

por Liu, Nina, Girvin, Mark E., Brenowitz, Michael, Lai, Jonathan R.
Publicado 2019

Bispecific Antibody Affords Complete Post-Exposure Protection of Mice from Both Ebola (Zaire) and Sudan Viruses

por Frei, Julia C., Nyakatura, Elisabeth K., Zak, Samantha E., Bakken, Russell R., Chandran, Kartik, Dye, John M., Lai, Jonathan R.
Publicado 2016

Inhibition of Ebola Virus Entry by a C-peptide Targeted to Endosomes

por Miller, Emily Happy, Harrison, Joseph S., Radoshitzky, Sheli R., Higgins, Chelsea D., Chi, Xiaoli, Dong, Lian, Kuhn, Jens H., Bavari, Sina, Lai, Jonathan R., Chandran, Kartik
Publicado 2011

Monoclonal antibodies from humans with Mycobacterium tuberculosis exposure or latent infection recognize distinct arabinomannan epitopes

por Ishida, Elise, Corrigan, Devin T., Malonis, Ryan J., Hofmann, Daniel, Chen, Tingting, Amin, Anita G., Chatterjee, Delphi, Joe, Maju, Lowary, Todd L., Lai, Jonathan R., Achkar, Jacqueline M.
Publicado 2021

Structural Characterization of the Glycoprotein GP2 Core Domain from the CAS Virus, a Novel Arenavirus-Like Species

por Koellhoffer, Jayne F., Dai, Zhou, Malashkevich, Vladimir N., Stenglein, Mark D., Liu, Yanyun, Toro, Rafael, S. Harrison, Joseph, Chandran, Kartik, DeRisi, Joseph L., Almo, Steven C., Lai, Jonathan R.
Publicado 2014

A Powassan virus domain III nanoparticle immunogen elicits neutralizing and protective antibodies in mice

por Malonis, Ryan J., Georgiev, George I., Haslwanter, Denise, VanBlargan, Laura A., Fallon, Georgia, Vergnolle, Olivia, Cahill, Sean M., Harris, Richard, Cowburn, David, Chandran, Kartik, Diamond, Michael S., Lai, Jonathan R.
Publicado 2022

Synthetic Antibodies with a Human Framework That Protect Mice from Lethal Sudan Ebolavirus Challenge

por Chen, Gang, Koellhoffer, Jayne F., Zak, Samantha E., Frei, Julia C., Liu, Nina, Long, Hua, Ye, Wei, Nagar, Kaajal, Pan, Guohua, Chandran, Kartik, Dye, John M., Sidhu, Sachdev S., Lai, Jonathan R.
Publicado 2014

Two Distinct Lysosomal Targeting Strategies Afford Trojan Horse Antibodies With Pan-Filovirus Activity

por Wirchnianski, Ariel S., Wec, Anna Z., Nyakatura, Elisabeth K., Herbert, Andrew S., Slough, Megan M., Kuehne, Ana I., Mittler, Eva, Jangra, Rohit K., Teruya, Jonathan, Dye, John M., Lai, Jonathan R., Chandran, Kartik
Publicado 2021

Probing differences among Aβ oligomers with two triangular trimers derived from Aβ

por Kreutzer, Adam G., Guaglianone, Gretchen, Yoo, Stan, Parrocha, Chelsea Marie T., Ruttenberg, Sarah M., Malonis, Ryan J., Tong, Karen, Lin, Yu-Fu, Nguyen, Jennifer T., Howitz, William J., Diab, Michelle N., Hamza, Imane L., Lai, Jonathan R., Wysocki, Vicki H., Nowick, James S.
Publicado 2023

Human monoclonal antibodies against chikungunya virus target multiple distinct epitopes in the E1 and E2 glycoproteins

por Quiroz, Jose A., Malonis, Ryan J., Thackray, Larissa B., Cohen, Courtney A., Pallesen, Jesper, Jangra, Rohit K., Brown, Rebecca S., Hofmann, Daniel, Holtsberg, Frederick W., Shulenin, Sergey, Nyakatura, Elisabeth K., Durnell, Lorellin A., Rayannavar, Vinayak, Daily, Johanna P., Ward, Andrew B., Aman, M. Javad, Dye, John M., Chandran, Kartik, Diamond, Michael S., Kielian, Margaret, Lai, Jonathan R.
Publicado 2019

A replication-competent vesicular stomatitis virus for studies of SARS-CoV-2 spike-mediated cell entry and its inhibition

por Dieterle, M. Eugenia, Haslwanter, Denise, Bortz, Robert H., Wirchnianski, Ariel S., Lasso, Gorka, Vergnolle, Olivia, Abbasi, Shawn A., Fels, J. Maximilian, Laudermilch, Ethan, Florez, Catalina, Mengotto, Amanda, Kimmel, Duncan, Malonis, Ryan J., Georgiev, George, Quiroz, Jose, Barnhill, Jason, Pirofski, Liise-anne, Daily, Johanna P., Dye, John M., Lai, Jonathan R., Herbert, Andrew S., Chandran, Kartik, Jangra, Rohit K.
Publicado 2020

A Replication-Competent Vesicular Stomatitis Virus for Studies of SARS-CoV-2 Spike-Mediated Cell Entry and Its Inhibition

por Dieterle, M. Eugenia, Haslwanter, Denise, Bortz, Robert H., Wirchnianski, Ariel S., Lasso, Gorka, Vergnolle, Olivia, Abbasi, Shawn A., Fels, J. Maximilian, Laudermilch, Ethan, Florez, Catalina, Mengotto, Amanda, Kimmel, Duncan, Malonis, Ryan J., Georgiev, George, Quiroz, Jose, Barnhill, Jason, Pirofski, Liise-anne, Daily, Johanna P., Dye, John M., Lai, Jonathan R., Herbert, Andrew S., Chandran, Kartik, Jangra, Rohit K.
Publicado 2020

A Combination of Receptor-Binding Domain and N-Terminal Domain Neutralizing Antibodies Limits the Generation of SARS-CoV-2 Spike Neutralization-Escape Mutants

por Haslwanter, Denise, Dieterle, M. Eugenia, Wec, Anna Z., O’Brien, Cecilia M., Sakharkar, Mrunal, Florez, Catalina, Tong, Karen, Rappazzo, C. Garrett, Lasso, Gorka, Vergnolle, Olivia, Wirchnianski, Ariel S., Bortz, Robert H., Laudermilch, Ethan, Fels, J. Maximilian, Mengotto, Amanda, Malonis, Ryan J., Georgiev, George I., Quiroz, Jose A., Wrapp, Daniel, Wang, Nianshuang, Dye, Kathryn E., Barnhill, Jason, Dye, John M., McLellan, Jason S., Daily, Johanna P., Lai, Jonathan R., Herbert, Andrew S., Walker, Laura M., Chandran, Kartik, Jangra, Rohit K.
Publicado 2021

Longitudinally monitored immune biomarkers predict the timing of COVID-19 outcomes

por Lasso, Gorka, Khan, Saad, Allen, Stephanie A., Mariano, Margarette, Florez, Catalina, Orner, Erika P., Quiroz, Jose A., Quevedo, Gregory, Massimi, Aldo, Hegde, Aditi, Wirchnianski, Ariel S., Bortz, Robert H., Malonis, Ryan J., Georgiev, George I., Tong, Karen, Herrera, Natalia G., Morano, Nicholas C., Garforth, Scott J., Malaviya, Avinash, Khokhar, Ahmed, Laudermilch, Ethan, Dieterle, M. Eugenia, Fels, J. Maximilian, Haslwanter, Denise, Jangra, Rohit K., Barnhill, Jason, Almo, Steven C., Chandran, Kartik, Lai, Jonathan R., Kelly, Libusha, Daily, Johanna P., Vergnolle, Olivia
Publicado 2022

Antibody Treatment of Ebola and Sudan Virus Infection via a Uniquely Exposed Epitope within the Glycoprotein Receptor-Binding Site

por Howell, Katie A., Qiu, Xiangguo, Brannan, Jennifer M., Bryan, Christopher, Davidson, Edgar, Holtsberg, Frederick W., Wec, Anna Z., Shulenin, Sergey, Biggins, Julia E., Douglas, Robin, Enterlein, Sven G., Turner, Hannah L., Pallesen, Jesper, Murin, Charles D., He, Shihua, Kroeker, Andrea, Vu, Hong, Herbert, Andrew S., Fusco, Marnie L., Nyakatura, Elisabeth K., Lai, Jonathan R., Keck, Zhen-Yong, Foung, Steven K.H., Saphire, Erica Ollmann, Zeitlin, Larry, Ward, Andrew B., Chandran, Kartik, Doranz, Benjamin J., Kobinger, Gary P., Dye, John M., Aman, M. Javad
Publicado 2016

Characterization of the SARS-CoV-2 S Protein: Biophysical, Biochemical, Structural, and Antigenic Analysis

por Herrera, Natalia G., Morano, Nicholas C., Celikgil, Alev, Georgiev, George I., Malonis, Ryan J., Lee, James H., Tong, Karen, Vergnolle, Olivia, Massimi, Aldo B., Yen, Laura Y., Noble, Alex J., Kopylov, Mykhailo, Bonanno, Jeffrey B., Garrett-Thomson, Sarah C., Hayes, David B., Bortz, Robert H., Wirchnianski, Ariel S., Florez, Catalina, Laudermilch, Ethan, Haslwanter, Denise, Fels, J. Maximilian, Dieterle, M. Eugenia, Jangra, Rohit K., Barnhill, Jason, Mengotto, Amanda, Kimmel, Duncan, Daily, Johanna P., Pirofski, Liise-anne, Chandran, Kartik, Brenowitz, Michael, Garforth, Scott J., Eng, Edward T., Lai, Jonathan R., Almo, Steven C.
Publicado 2020

Characterization of the SARS-CoV-2 S Protein: Biophysical, Biochemical, Structural, and Antigenic Analysis

por Herrera, Natalia G., Morano, Nicholas C., Celikgil, Alev, Georgiev, George I., Malonis, Ryan J., Lee, James H., Tong, Karen, Vergnolle, Olivia, Massimi, Aldo B., Yen, Laura Y., Noble, Alex J., Kopylov, Mykhailo, Bonanno, Jeffrey B., Garrett-Thomson, Sarah C., Hayes, David B., Bortz, Robert H., Wirchnianski, Ariel S., Florez, Catalina, Laudermilch, Ethan, Haslwanter, Denise, Fels, J. Maximilian, Dieterle, M. Eugenia, Jangra, Rohit K., Barnhill, Jason, Mengotto, Amanda, Kimmel, Duncan, Daily, Johanna P., Pirofski, Liise-anne, Chandran, Kartik, Brenowitz, Michael, Garforth, Scott J., Eng, Edward T., Lai, Jonathan R., Almo, Steven C.
Publicado 2020