Immunotherapeutic Potential of Extracellular Vesicles

por Zhang, Bin, Yin, Yijun, Lai, Ruenn Chai, Lim, Sai Kiang
Publicado 2014

Therapeutic Efficacy of Mesenchymal Stem/Stromal Cell Small Extracellular Vesicles in Alleviating Arthritic Progression by Restoring Macrophage Balance

por Zhang, Bin, Lai, Ruenn Chai, Sim, Wei Kian, Lim, Sai Kiang
Publicado 2023

MSC exosome works through a protein-based mechanism of action

por Toh, Wei Seong, Lai, Ruenn Chai, Zhang, Bin, Lim, Sai Kiang
Publicado 2018

MSC−sEV Treatment Polarizes Pro−Fibrotic M2 Macrophages without Exacerbating Liver Fibrosis in NASH

por Zhang, Bin, Zhang, Biyan, Lai, Ruenn Chai, Sim, Wei Kian, Lam, Kong Peng, Lim, Sai Kiang
Publicado 2023

Mesenchymal stem cell-derived exosomes promote hepatic regeneration in drug-induced liver injury models

por Tan, Cheau Yih, Lai, Ruenn Chai, Wong, Winnie, Dan, Yock Young, Lim, Sai-Kiang, Ho, Han Kiat
Publicado 2014

Topical Application of Mesenchymal Stem Cell Exosomes Alleviates the Imiquimod Induced Psoriasis-Like Inflammation

por Zhang, Bin, Lai, Ruenn Chai, Sim, Wei Kian, Choo, Andre Boon Hwa, Lane, Ellen Birgit, Lim, Sai Kiang
Publicado 2021

Assessment of Tumorigenic Potential in Mesenchymal-Stem/Stromal-Cell-Derived Small Extracellular Vesicles (MSC-sEV)

por Tan, Thong Teck, Lai, Ruenn Chai, Padmanabhan, Jayanthi, Sim, Wei Kian, Choo, Andre Boon Hwa, Lim, Sai Kiang
Publicado 2021

Mesenchymal stem cell secretes microparticles enriched in pre-microRNAs

por Chen, Tian Sheng, Lai, Ruenn Chai, Lee, May May, Choo, Andre Boon Hwa, Lee, Chuen Neng, Lim, Sai Kiang
Publicado 2010

Therapeutic MSC exosomes are derived from lipid raft microdomains in the plasma membrane

por Tan, Soon Sim, Yin, Yijun, Lee, Tricia, Lai, Ruenn Chai, Yeo, Ronne Wee Yeh, Zhang, Bin, Choo, Andre, Lim, Sai Kiang
Publicado 2013

Mechanism for the attenuation of neutrophil and complement hyperactivity by MSC exosomes

por Loh, Jia Tong, Zhang, Bin, Teo, Joey Kay Hui, Lai, Ruenn Chai, Choo, Andre Boon Hwa, Lam, Kong-Peng, Lim, Sai Kiang
Publicado 2022

HuMSC-EV induce monocyte/macrophage mobilization to orchestrate neovascularization in wound healing process following radiation injury

por Loinard, Céline, Ribault, Alexandre, Lhomme, Bruno, Benderitter, Marc, Flamant, Stéphane, Paul, Sandrine, Dubois, Valérie, Lai, Ruenn Chai, Lim, Sai Kiang, Tamarat, Radia
Publicado 2023

Proteolytic Potential of the MSC Exosome Proteome: Implications for an Exosome-Mediated Delivery of Therapeutic Proteasome

por Lai, Ruenn Chai, Tan, Soon Sim, Teh, Bao Ju, Sze, Siu Kwan, Arslan, Fatih, de Kleijn, Dominique P., Choo, Andre, Lim, Sai Kiang
Publicado 2012

Mesenchymal stromal cell exosomes enhance dental pulp cell functions and promote pulp-dentin regeneration

por Shi, Jiajun, Teo, Kristeen Ye Wen, Zhang, Shipin, Lai, Ruenn Chai, Rosa, Vinicius, Tong, Huei Jinn, Duggal, Mandeep S., Lim, Sai Kiang, Toh, Wei Seong
Publicado 2023

Mesenchymal Stromal Cell Exosomes Mediate M2-like Macrophage Polarization through CD73/Ecto-5′-Nucleotidase Activity

por Teo, Kristeen Ye Wen, Zhang, Shipin, Loh, Jia Tong, Lai, Ruenn Chai, Hey, Hwee Weng Dennis, Lam, Kong-Peng, Lim, Sai Kiang, Toh, Wei Seong
Publicado 2023

Systemic Mesenchymal Stem Cell-Derived Exosomes Reduce Myocardial Infarct Size: Characterization With MRI in a Porcine Model

por Charles, Christopher J., Li, Renee R., Yeung, Teresa, Mazlan, Stephane M. Ibraham, Lai, Ruenn Chai, de Kleijn, Dominique P. V., Lim, Sai Kiang, Richards, A. Mark
Publicado 2020

Enabling a robust scalable manufacturing process for therapeutic exosomes through oncogenic immortalization of human ESC-derived MSCs

por Chen, Tian Sheng, Arslan, Fatih, Yin, Yijun, Tan, Soon Sim, Lai, Ruenn Chai, Choo, Andre Boon Hwa, Padmanabhan, Jayanthi, Lee, Chuen Neng, de Kleijn, Dominique PV, Lim, Sai Kiang
Publicado 2011

Mesenchymal Stem Cell Exosomes as Immunomodulatory Therapy for Corneal Scarring

por Ong, Hon Shing, Riau, Andri K., Yam, Gary Hin-Fai, Yusoff, Nur Zahirah Binte M., Han, Evelina J. Y., Goh, Tze-Wei, Lai, Ruenn Chai, Lim, Sai Kiang, Mehta, Jodhbir S.
Publicado 2023

MSC secretes at least 3 EV types each with a unique permutation of membrane lipid, protein and RNA

por Lai, Ruenn Chai, Tan, Soon Sim, Yeo, Ronne Wee Yeh, Choo, Andre Boon Hwa, Reiner, Agnes T., Su, Yan, Shen, Yang, Fu, Zhiyan, Alexander, Lezhava, Sze, Siu Kwan, Lim, Sai Kiang
Publicado 2016

Defining mesenchymal stromal cell (MSC)-derived small extracellular vesicles for therapeutic applications

por Witwer, Kenneth W., Van Balkom, Bas W.M., Bruno, Stefania, Choo, Andre, Dominici, Massimo, Gimona, Mario, Hill, Andrew F., De Kleijn, Dominique, Koh, Mickey, Lai, Ruenn Chai, Mitsialis, S. Alex, Ortiz, Luis A., Rohde, Eva, Asada, Takashi, Toh, Wei Seong, Weiss, Daniel J., Zheng, Lei, Giebel, Bernd, Lim, Sai Kiang
Publicado 2019

Mesenchymal stem cell‐derived extracellular vesicles reduce senescence and extend health span in mouse models of aging

por Dorronsoro, Akaitz, Santiago, Fernando E., Grassi, Diego, Zhang, Tianpeng, Lai, Ruenn Chai, McGowan, Sara J., Angelini, Luise, Lavasani, Mitra, Corbo, Lana, Lu, Aiping, Brooks, Robert W., Garcia‐Contreras, Marta, Stolz, Donna B., Amelio, Antonio, Boregowda, Siddaraju V., Fallahi, Mohammad, Reich, Adrian, Ricordi, Camillo, Phinney, Donald G., Huard, Johnny, Lim, Sai Kiang, Niedernhofer, Laura J., Robbins, Paul D.
Publicado 2021