Regulatory Roles of PINK1-Parkin and AMPK in Ubiquitin-Dependent Skeletal Muscle Mitophagy

por Seabright, Alex P., Lai, Yu-Chiang
Publicado 2020

Exercise mediates ubiquitin signalling in human skeletal muscle

por Lord, Samuel O., Lai, Yu‐Chiang
Publicado 2022

The Role of Skeletal Muscle Glycogen Breakdown for Regulation of Insulin Sensitivity by Exercise

por Jensen, Jørgen, Rustad, Per Inge, Kolnes, Anders Jensen, Lai, Yu-Chiang
Publicado 2011

Probes of Ubiquitin E3 ligases distinguish different stages of Parkin activation

por Pao, Kuan-Chuan, Stanley, Mathew, Han, Cong, Lai, Yu-Chiang, Murphy, Paul, Balk, Kristin, Wood, Nicola T., Corti, Olga, Corvol, Jean-Christophe, Muqit, Miratul M.K., Virdee, Satpal
Publicado 2016

PINK1-dependent phosphorylation of Serine111 within the SF3 motif of Rab GTPases impairs effector interactions and LRRK2-mediated phosphorylation at Threonine72

por Vieweg, Sophie, Mulholland, Katie, Bräuning, Bastian, Kachariya, Nitin, Lai, Yu-Chiang, Toth, Rachel, Singh, Pawan Kishor, Volpi, Ilaria, Sattler, Michael, Groll, Michael, Itzen, Aymelt, Muqit, Miratul M. K.
Publicado 2020

Kinetin Riboside and Its ProTides Activate the Parkinson’s Disease Associated PTEN-Induced Putative Kinase 1 (PINK1) Independent of Mitochondrial Depolarization

por Osgerby, Laura, Lai, Yu-Chiang, Thornton, Peter J., Amalfitano, Joseph, Le Duff, Cécile S., Jabeen, Iqra, Kadri, Hachemi, Miccoli, Ageo, Tucker, James H. R., Muqit, Miratul M. K., Mehellou, Youcef
Publicado 2017

Global Deletion of 11β-HSD1 Prevents Muscle Wasting Associated with Glucocorticoid Therapy in Polyarthritis

por Webster, Justine M., Sagmeister, Michael S., Fenton, Chloe G., Seabright, Alex P., Lai, Yu-Chiang, Jones, Simon W., Filer, Andrew, Cooper, Mark S., Lavery, Gareth G., Raza, Karim, Langen, Ramon, Hardy, Rowan S.
Publicado 2021

Benzimidazole derivative small-molecule 991 enhances AMPK activity and glucose uptake induced by AICAR or contraction in skeletal muscle

por Bultot, Laurent, Jensen, Thomas E., Lai, Yu-Chiang, Madsen, Agnete L. B., Collodet, Caterina, Kviklyte, Samanta, Deak, Maria, Yavari, Arash, Foretz, Marc, Ghaffari, Sahar, Bellahcene, Mohamed, Ashrafian, Houman, Rider, Mark H., Richter, Erik A., Sakamoto, Kei
Publicado 2016

AMPK activation induces mitophagy and promotes mitochondrial fission while activating TBK1 in a PINK1‐Parkin independent manner

por Seabright, Alex P., Fine, Nicholas H. F., Barlow, Jonathan P., Lord, Samuel O., Musa, Ibrahim, Gray, Alexander, Bryant, Jack A., Banzhaf, Manuel, Lavery, Gareth G., Hardie, D. Grahame, Hodson, David J., Philp, Andrew, Lai, Yu‐Chiang
Publicado 2020

Phosphoproteomic screening identifies Rab GTPases as novel downstream targets of PINK1

por Lai, Yu‐Chiang, Kondapalli, Chandana, Lehneck, Ronny, Procter, James B, Dill, Brian D, Woodroof, Helen I, Gourlay, Robert, Peggie, Mark, Macartney, Thomas J, Corti, Olga, Corvol, Jean‐Christophe, Campbell, David G, Itzen, Aymelt, Trost, Matthias, Muqit, Miratul MK
Publicado 2015

The Effect of Ex Vivo Human Serum from Liver Disease Patients on Cellular Protein Synthesis and Growth

por Allen, Sophie L., Seabright, Alex P., Quinlan, Jonathan I., Dhaliwal, Amritpal, Williams, Felicity R., Fine, Nicholas H. F., Hodson, David J., Armstrong, Matthew J., Elsharkaway, Ahmed M., Greig, Carolyn A., Lai, Yu-Chiang, Lord, Janet M., Lavery, Gareth G., Breen, Leigh
Publicado 2022

PDX1(LOW) MAFA(LOW) β-cells contribute to islet function and insulin release

por Nasteska, Daniela, Fine, Nicholas H. F., Ashford, Fiona B., Cuozzo, Federica, Viloria, Katrina, Smith, Gabrielle, Dahir, Aisha, Dawson, Peter W. J., Lai, Yu-Chiang, Bastidas-Ponce, Aimée, Bakhti, Mostafa, Rutter, Guy A., Fiancette, Remi, Nano, Rita, Piemonti, Lorenzo, Lickert, Heiko, Zhou, Qiao, Akerman, Ildem, Hodson, David J.
Publicado 2021

Author Correction: PDX1(LOW) MAFA(LOW) β-cells contribute to islet function and insulin release

por Nasteska, Daniela, Fine, Nicholas H. F., Ashford, Fiona B., Cuozzo, Federica, Viloria, Katrina, Smith, Gabrielle, Dahir, Aisha, Dawson, Peter W. J., Lai, Yu-Chiang, Bastidas-Ponce, Aimée, Bakhti, Mostafa, Rutter, Guy A., Fiancette, Remi, Nano, Rita, Piemonti, Lorenzo, Lickert, Heiko, Zhou, Qiao, Akerman, Ildem, Hodson, David J.
Publicado 2021

Nicotinamide Riboside Augments the Aged Human Skeletal Muscle NAD(+) Metabolome and Induces Transcriptomic and Anti-inflammatory Signatures

por Elhassan, Yasir S., Kluckova, Katarina, Fletcher, Rachel S., Schmidt, Mark S., Garten, Antje, Doig, Craig L., Cartwright, David M., Oakey, Lucy, Burley, Claire V., Jenkinson, Ned, Wilson, Martin, Lucas, Samuel J.E., Akerman, Ildem, Seabright, Alex, Lai, Yu-Chiang, Tennant, Daniel A., Nightingale, Peter, Wallis, Gareth A., Manolopoulos, Konstantinos N., Brenner, Charles, Philp, Andrew, Lavery, Gareth G.
Publicado 2019