Quantitative conformational profiling of kinase inhibitors reveals origins of selectivity for Aurora kinase activation states

por Lake, Eric W., Muretta, Joseph M., Thompson, Andrew R., Rasmussen, Damien M., Majumdar, Abir, Faber, Erik B., Ruff, Emily F., Thomas, David D., Levinson, Nicholas M.
Publicado 2018

A dynamic mechanism for allosteric activation of Aurora kinase A by activation loop phosphorylation

por Ruff, Emily F, Muretta, Joseph M, Thompson, Andrew R, Lake, Eric W, Cyphers, Soreen, Albanese, Steven K, Hanson, Sonya M, Behr, Julie M, Thomas, David D, Chodera, John D, Levinson, Nicholas M
Publicado 2018

Mechanisms of SARS-CoV-2 neutralization by shark variable new antigen receptors elucidated through X-ray crystallography

por Ubah, Obinna C., Lake, Eric W., Gunaratne, Gihan S., Gallant, Joseph P., Fernie, Marie, Robertson, Austin J., Marchant, Jonathan S., Bold, Tyler D., Langlois, Ryan A., Matchett, William E., Thiede, Joshua M., Shi, Ke, Yin, Lulu, Moeller, Nicholas H., Banerjee, Surajit, Ferguson, Laura, Kovaleva, Marina, Porter, Andrew J., Aihara, Hideki, LeBeau, Aaron M., Barelle, Caroline J.
Publicado 2021