Efficient secretion of small proteins in mammalian cells relies on Sec62-dependent posttranslational translocation

por Lakkaraju, Asvin K. K., Thankappan, Ratheeshkumar, Mary, Camille, Garrison, Jennifer L., Taunton, Jack, Strub, Katharina
Publicado 2012

Loss of PIKfyve drives the spongiform degeneration in prion diseases

por Lakkaraju, Asvin K K, Frontzek, Karl, Lemes, Emina, Herrmann, Uli, Losa, Marco, Marpakwar, Rajlakshmi, Aguzzi, Adriano
Publicado 2021

Glial activation in prion diseases is selectively triggered by neuronal PrP(Sc)

por Lakkaraju, Asvin K. K., Sorce, Silvia, Senatore, Assunta, Nuvolone, Mario, Guo, Jingjing, Schwarz, Petra, Moos, Rita, Pelczar, Pawel, Aguzzi, Adriano
Publicado 2022

Soluble dimeric prion protein ligand activates Adgrg6 receptor but does not rescue early signs of demyelination in PrP-deficient mice

por Henzi, Anna, Senatore, Assunta, Lakkaraju, Asvin K. K., Scheckel, Claudia, Mühle, Jonas, Reimann, Regina, Sorce, Silvia, Schertler, Gebhard, Toyka, Klaus V., Aguzzi, Adriano
Publicado 2020

Inhibition of group-I metabotropic glutamate receptors protects against prion toxicity

por Goniotaki, Despoina, Lakkaraju, Asvin K. K., Shrivastava, Amulya N., Bakirci, Pamela, Sorce, Silvia, Senatore, Assunta, Marpakwar, Rajlakshmi, Hornemann, Simone, Gasparini, Fabrizio, Triller, Antoine, Aguzzi, Adriano
Publicado 2017

Neurodegeneration and Unfolded-Protein Response in Mice Expressing a Membrane-Tethered Flexible Tail of PrP

por Dametto, Paolo, Lakkaraju, Asvin K. K., Bridel, Claire, Villiger, Lukas, O’Connor, Tracy, Herrmann, Uli S., Pelczar, Pawel, Rülicke, Thomas, McHugh, Donal, Adili, Arlind, Aguzzi, Adriano
Publicado 2015

GPR56/ADGRG1 regulates development and maintenance of peripheral myelin

por Ackerman, Sarah D., Luo, Rong, Poitelon, Yannick, Mogha, Amit, Harty, Breanne L., D’Rozario, Mitchell, Sanchez, Nicholas E., Lakkaraju, Asvin K.K., Gamble, Paul, Li, Jun, Qu, Jun, MacEwan, Matthew R., Ray, Wilson Zachary, Aguzzi, Adriano, Feltri, M. Laura, Piao, Xianhua, Monk, Kelly R.
Publicado 2018