Differences in the pharmacokinetics of currently approved antimalarial drugs in uncomplicated malaria patients compared to healthy subjects

por Jain, Jay Prakash, Lakshminarayana, Suresh B, Lefèvre, Gilbert, Sivasubramanian, Rama, Blasco, Francesca, Sunkara, Gangadhar
Publicado 2012

Pharmacokinetic-Pharmacodynamic Analysis of Spiroindolone Analogs and KAE609 in a Murine Malaria Model

por Lakshminarayana, Suresh B., Freymond, Céline, Fischli, Christoph, Yu, Jing, Weber, Sebastian, Goh, Anne, Yeung, Bryan K. S., Ho, Paul C., Dartois, Véronique, Diagana, Thierry T., Rottmann, Matthias, Blasco, Francesca
Publicado 2015

Anti-Trypanosomal Proteasome Inhibitors Cure Hemolymphatic and Meningoencephalic Murine Infection Models of African Trypanosomiasis

por Rao, Srinivasa P S, Lakshminarayana, Suresh B, Jiricek, Jan, Kaiser, Marcel, Ritchie, Ryan, Myburgh, Elmarie, Supek, Frantisek, Tuntland, Tove, Nagle, Advait, Molteni, Valentina, Mäser, Pascal, Mottram, Jeremy C, Barrett, Michael P, Diagana, Thierry T
Publicado 2020

Lerisetron Analogues with Antimalarial Properties: Synthesis, Structure–Activity Relationship Studies, and Biological Assessment

por Mueller, Rudolf, Reddy, Virsinha, Nchinda, Aloysius T., Mebrahtu, Fanuel, Taylor, Dale, Lawrence, Nina, Tanner, Lloyd, Barnabe, Marine, Eyermann, Charles J., Zou, Bin, Kondreddi, Ravinder R., Lakshminarayana, Suresh B., Rottmann, Matthias, Street, Leslie J., Chibale, Kelly
Publicado 2020

Pharmacokinetics-Pharmacodynamics Analysis of Bicyclic 4-Nitroimidazole Analogs in a Murine Model of Tuberculosis

por Lakshminarayana, Suresh B., Boshoff, Helena I. M., Cherian, Joseph, Ravindran, Sindhu, Goh, Anne, Jiricek, Jan, Nanjundappa, Mahesh, Nayyar, Amit, Gurumurthy, Meera, Singh, Ramandeep, Dick, Thomas, Blasco, Francesca, Barry, Clifton E., Ho, Paul C., Manjunatha, Ujjini H.
Publicado 2014

PI4 Kinase Is a Prophylactic but Not Radical Curative Target in Plasmodium vivax-Type Malaria Parasites

por Zeeman, Anne-Marie, Lakshminarayana, Suresh B., van der Werff, Nicole, Klooster, Els J., Voorberg-van der Wel, Annemarie, Kondreddi, Ravinder R., Bodenreider, Christophe, Simon, Oliver, Sauerwein, Robert, Yeung, Bryan K. S., Diagana, Thierry T., Kocken, Clemens H. M.
Publicado 2016

Spirotetrahydro β-Carbolines (Spiroindolones): A New Class of Potent and Orally Efficacious Compounds for the Treatment of Malaria

por Yeung, Bryan K. S., Zou, Bin, Rottmann, Matthias, Lakshminarayana, Suresh B., Ang, Shi Hua, Leong, Seh Yong, Tan, Jocelyn, Wong, Josephine, Keller-Maerki, Sonja, Fischli, Christoph, Goh, Anne, Schmitt, Esther K., Krastel, Philipp, Francotte, Eric, Kuhen, Kelli, Plouffe, David, Henson, Kerstin, Wagner, Trixie, Winzeler, Elizabeth A., Petersen, Frank, Brun, Reto, Dartois, Veronique, Diagana, Thierry T., Keller, Thomas H.
Publicado 2010

Targeting the trypanosome kinetochore with CLK1 protein kinase inhibitors

por Saldivia, Manuel, Fang, Eric, Ma, Xiaolei, Myburgh, Elmarie, Carnielli, Juliana B. T., Bower-Lepts, Christopher, Brown, Elaine, Ritchie, Ryan, Lakshminarayana, Suresh B., Chen, Yen-Liang, Patra, Debjani, Ornelas, Elizabeth, Koh, Hazel X. Y., Williams, Sarah, Supek, Frantisek, Paape, Daniel, McCulloch, Richard, Kaiser, Marcel, Barrett, Michael P., Jiricek, Jan, Diagana, Thierry T., Mottram, Jeremy C., Rao, Srinivasa P.S.
Publicado 2020

A Cryptosporidium PI(4)K inhibitor is a drug candidate for cryptosporidiosis

por Manjunatha, Ujjini H., Vinayak, Sumiti, Zambriski, Jennifer A., Chao, Alexander T., Sy, Tracy, Noble, Christian G., Bonamy, Ghislain M. C., Kondreddi, Ravinder R., Zou, Bin, Gedeck, Peter, Brooks, Carrie F., Herbert, Gillian T., Sateriale, Adam, Tandel, Jayesh, Noh, Susan, Lakshminarayana, Suresh B., Lim, Siau H., Goodman, Laura B., Bodenreider, Christophe, Feng, Gu, Zhang, Lijun, Blasco, Francesca, Wagner, Juergen, Leong, F. Joel, Striepen, Boris, Diagana, Thierry T.
Publicado 2017

Imidazolopiperazines: Lead Optimization of the Second-Generation Antimalarial Agents

por Nagle, Advait, Wu, Tao, Kuhen, Kelli, Gagaring, Kerstin, Borboa, Rachel, Francek, Caroline, Chen, Zhong, Plouffe, David, Lin, Xuena, Caldwell, Christopher, Ek, Jared, Skolnik, Suzanne, Liu, Fenghua, Wang, Jianling, Chang, Jonathan, Li, Chun, Liu, Bo, Hollenbeck, Thomas, Tuntland, Tove, Isbell, John, Chuan, Tiffany, Alper, Philip B., Fischli, Christoph, Brun, Reto, Lakshminarayana, Suresh B., Rottmann, Matthias, Diagana, Thierry T., Winzeler, Elizabeth A., Glynne, Richard, Tully, David C., Chatterjee, Arnab K.
Publicado 2012

Discovery of Novel Quinoline-Based Proteasome Inhibitors for Human African Trypanosomiasis (HAT)

por Koester, Dennis C., Marx, Vanessa M., Williams, Sarah, Jiricek, Jan, Dauphinais, Maxime, René, Olivier, Miller, Sarah L., Zhang, Lei, Patra, Debjani, Chen, Yen-Liang, Cheung, Harry, Gable, Jonathan, Lakshminarayana, Suresh B., Osborne, Colin, Galarneau, Jean-Rene, Kulkarni, Upendra, Richmond, Wendy, Bretz, Angela, Xiao, Linda, Supek, Frantisek, Wiesmann, Christian, Honnappa, Srinivas, Be, Celine, Mäser, Pascal, Kaiser, Marcel, Ritchie, Ryan, Barrett, Michael P., Diagana, Thierry T., Sarko, Christopher, Rao, Srinivasa P. S.
Publicado 2022

Imidazolopiperazines: Hit to Lead Optimization of New Antimalarial Agents

por Wu, Tao, Nagle, Advait, Kuhen, Kelli, Gagaring, Kerstin, Borboa, Rachel, Francek, Caroline, Chen, Zhong, Plouffe, David, Goh, Anne, Lakshminarayana, Suresh B., Wu, Jeanette, Ang, Hui Qing, Zeng, Peiting, Kang, Min Low, Tan, William, Tan, Maria, Ye, Nicole, Lin, Xuena, Caldwell, Christopher, Ek, Jared, Skolnik, Suzanne, Liu, Fenghua, Wang, Jianling, Chang, Jonathan, Li, Chun, Hollenbeck, Thomas, Tuntland, Tove, Isbell, John, Fischli, Christoph, Brun, Reto, Rottmann, Matthias, Dartois, Veronique, Keller, Thomas, Diagana, Thierry, Winzeler, Elizabeth, Glynne, Richard, Tully, David C., Chatterjee, Arnab K.
Publicado 2011

A chemical genetic screen in Mycobacterium tuberculosis identifies carbon-source-dependent growth inhibitors devoid of in vivo efficacy

por Pethe, Kevin, Sequeira, Patricia C., Agarwalla, Sanjay, Rhee, Kyu, Kuhen, Kelli, Phong, Wai Yee, Patel, Viral, Beer, David, Walker, John R., Duraiswamy, Jeyaraj, Jiricek, Jan, Keller, Thomas H., Chatterjee, Arnab, Tan, Mai Ping, Ujjini, Manjunatha, Rao, Srinivasa P.S., Camacho, Luis, Bifani, Pablo, Mak, Puiying A., Ma, Ida, Barnes, S. Whitney, Chen, Zhong, Plouffe, David, Thayalan, Pamela, Ng, Seow Hwee, Au, Melvin, Lee, Boon Heng, Tan, Bee Huat, Ravindran, Sindhu, Nanjundappa, Mahesh, Lin, Xiuhua, Goh, Anne, Lakshminarayana, Suresh B., Shoen, Carolyn, Cynamon, Michael, Kreiswirth, Barry, Dartois, Veronique, Peters, Eric C., Glynne, Richard, Brenner, Sydney, Dick, Thomas
Publicado 2010

Discovery and Preclinical Pharmacology of INE963, a Potent and Fast-Acting Blood-Stage Antimalarial with a High Barrier to Resistance and Potential for Single-Dose Cures in Uncompl...

por Taft, Benjamin R., Yokokawa, Fumiaki, Kirrane, Tom, Mata, Anne-Catherine, Huang, Richard, Blaquiere, Nicole, Waldron, Grace, Zou, Bin, Simon, Oliver, Vankadara, Subramanyam, Chan, Wai Ling, Ding, Mei, Sim, Sandra, Straimer, Judith, Guiguemde, Armand, Lakshminarayana, Suresh B., Jain, Jay Prakash, Bodenreider, Christophe, Thompson, Christopher, Lanshoeft, Christian, Shu, Wei, Fang, Eric, Qumber, Jafri, Chan, Katherine, Pei, Luying, Chen, Yen-Liang, Schulz, Hanna, Lim, Jessie, Abas, Siti Nurdiana, Ang, Xiaoman, Liu, Yugang, Angulo-Barturen, Iñigo, Jiménez-Díaz, María Belén, Gamo, Francisco Javier, Crespo-Fernandez, Benigno, Rosenthal, Philip J., Cooper, Roland A., Tumwebaze, Patrick, Aguiar, Anna Caroline Campos, Campo, Brice, Campbell, Simon, Wagner, Jürgen, Diagana, Thierry T., Sarko, Christopher
Publicado 2022