Activation of autophagy by FOXO3 regulates redox homeostasis during osteogenic differentiation

por Gómez-Puerto, M. C., Verhagen, L. P., Braat, A. K., Lam, E. W.-F., Coffer, P. J., Lorenowicz, M. J.
Publicado 2016

Aurora kinase A regulates Survivin stability through targeting FBXL7 in gastric cancer drug resistance and prognosis

por Kamran, M, Long, Z-J, Xu, D, Lv, S-S, Liu, B, Wang, C-L, Xu, J, Lam, E W-F, Liu, Q
Publicado 2017

RNF168 cooperates with RNF8 to mediate FOXM1 ubiquitination and degradation in breast cancer epirubicin treatment

por Kongsema, M, Zona, S, Karunarathna, U, Cabrera, E, Man, E P S, Yao, S, Shibakawa, A, Khoo, U-S, Medema, R H, Freire, R, Lam, E W-F
Publicado 2016

FOXA1 repression is associated with loss of BRCA1 and increased promoter methylation and chromatin silencing in breast cancer

por Gong, C, Fujino, K, Monteiro, L J, Gomes, A R, Drost, R, Davidson-Smith, H, Takeda, S, Khoo, U S, Jonkers, J, Sproul, D, Lam, E W-F
Publicado 2015

FOXM1 recruits nuclear Aurora kinase A to participate in a positive feedback loop essential for the self-renewal of breast cancer stem cells

por Yang, N, Wang, C, Wang, Z, Zona, S, Lin, S-X, Wang, X, Yan, M, Zheng, F-M, Li, S-S, Xu, B, Bella, L, Yong, J-S, Lam, E W-F, Liu, Q
Publicado 2017

Forkhead box K2 modulates epirubicin and paclitaxel sensitivity through FOXO3a in breast cancer

por de Moraes, G Nestal, Khongkow, P, Gong, C, Yao, S, Gomes, A R, Ji, Z, Kandola, N, Delbue, D, Man, E P S, Khoo, U S, Sharrocks, A D, Lam, E W-F
Publicado 2015

Paclitaxel targets FOXM1 to regulate KIF20A in mitotic catastrophe and breast cancer paclitaxel resistance

por Khongkow, P, Gomes, A R, Gong, C, Man, E P S, Tsang, J W-H, Zhao, F, Monteiro, L J, Coombes, R C, Medema, R H, Khoo, U S, Lam, E W-F
Publicado 2016

OTUB1 inhibits the ubiquitination and degradation of FOXM1 in breast cancer and epirubicin resistance

por Karunarathna, U, Kongsema, M, Zona, S, Gong, C, Cabrera, E, Gomes, A R, Man, E P S, Khongkow, P, Tsang, J W-H, Khoo, U-S, Medema, R H, Freire, R, Lam, E W-F
Publicado 2016

BRCA1 positively regulates FOXO3 expression by restricting FOXO3 gene methylation and epigenetic silencing through targeting EZH2 in breast cancer

por Gong, C, Yao, S, Gomes, A R, Man, E P S, Lee, H J, Gong, G, Chang, S, Kim, S-B, Fujino, K, Kim, S-W, Park, S K, Lee, J W, Lee, M H, Khoo, U S, Lam, E W-F
Publicado 2016

SUMOylation inhibits FOXM1 activity and delays mitotic transition

por Myatt, S S, Kongsema, M, Man, C W-Y, Kelly, D J, Gomes, A R, Khongkow, P, Karunarathna, U, Zona, S, Langer, J K, Dunsby, C W, Coombes, R C, French, P M, Brosens, J J, Lam, E W-F
Publicado 2014

FOXO3a and the MAPK p38 are activated by cetuximab to induce cell death and inhibit cell proliferation and their expression predicts cetuximab efficacy in colorectal cancer

por Marzi, L, Combes, E, Vié, N, Ayrolles-Torro, A, Tosi, D, Desigaud, D, Perez-Gracia, E, Larbouret, C, Montagut, C, Iglesias, M, Jarlier, M, Denis, V, Linares, L K, Lam, E W-F, Martineau, P, Del Rio, M, Gongora, C
Publicado 2016

p62/SQSTM1 enhances breast cancer stem-like properties by stabilizing MYC mRNA

por Xu, L-Z, Li, S-S, Zhou, W, Kang, Z-J, Zhang, Q-X, Kamran, M, Xu, J, Liang, D-P, Wang, C-L, Hou, Z-J, Wan, X-B, Wang, H-J, Lam, E W-F, Zhao, Z-W, Liu, Q
Publicado 2017

Dysfunction of the WT1-MEG3 signaling promotes AML leukemogenesis via p53-dependent and -independent pathways

por Lyu, Y, Lou, J, Yang, Y, Feng, J, Hao, Y, Huang, S, Yin, L, Xu, J, Huang, D, Ma, B, Zou, D, Wang, Y, Zhang, Y, Zhang, B, Chen, P, Yu, K, Lam, E W-F, Wang, X, Liu, Q, Yan, J, Jin, B
Publicado 2017

Erratum: Glycolysis gatekeeper PDK1 reprograms breast cancer stem cells under hypoxia

por Peng, F, Wang, J-H, Fan, W-J, Meng, Y-T, Li, M-M, Li, T-T, Cui, B, Wang, H-F, Zhao, Y, An, F, Guo, T, Liu, X-F, Zhang, L, Lv, L, Lv, D-K, Xu, L-Z, Xie, J-J, Lin, W-X, Lam, E W-F, Xu, J, Liu, Q
Publicado 2017

Glycolysis gatekeeper PDK1 reprograms breast cancer stem cells under hypoxia

por Peng, F, Wang, J-H, Fan, W-J, Meng, Y-T, Li, M-M, Li, T-T, Cui, B, Wang, H-F, Zhao, Y, An, F, Guo, T, Liu, X-F, Zhang, L, Lv, L, Lv, D-K, Xu, L-Z, Xie, J-J, Lin, W-X, Lam, E W-F, Xu, J, Liu, Q
Publicado 2018