Comparative Analysis of Cesium Chloride- and Iodixanol-Based Purification of Recombinant Adeno-Associated Viral Vectors for Preclinical Applications

por Strobel, Benjamin, Miller, Felix D., Rist, Wolfgang, Lamla, Thorsten
Publicado 2015

FKBP51 modulates steroid sensitivity and NFκB signalling: A novel anti‐inflammatory drug target

por Kästle, Marc, Kistler, Barbara, Lamla, Thorsten, Bretschneider, Tom, Lamb, David, Nicklin, Paul, Wyatt, David
Publicado 2018

Rosa26-LSL-dCas9-VPR: a versatile mouse model for tissue specific and simultaneous activation of multiple genes for drug discovery

por Pakalniškytė, Dalia, Schönberger, Tanja, Strobel, Benjamin, Stierstorfer, Birgit, Lamla, Thorsten, Schuler, Michael, Lenter, Martin
Publicado 2022

Development of a Bispecific Antibody-Based Platform for Retargeting of Capsid Modified AAV Vectors

por Kuklik, Juliane, Michelfelder, Stefan, Schiele, Felix, Kreuz, Sebastian, Lamla, Thorsten, Müller, Philipp, Park, John E.
Publicado 2021

Standardized, Scalable, and Timely Flexible Adeno-Associated Virus Vector Production Using Frozen High-Density HEK-293 Cell Stocks and CELLdiscs

por Strobel, Benjamin, Zuckschwerdt, Kai, Zimmermann, Gudrun, Mayer, Christine, Eytner, Ruth, Rechtsteiner, Philipp, Kreuz, Sebastian, Lamla, Thorsten
Publicado 2019

AAV-Mediated Expression of Human VEGF, TNF-α, and IL-6 Induces Retinal Pathology in Mice

por Weigelt, Carina M., Fuchs, Holger, Schönberger, Tanja, Stierstorfer, Birgit, Strobel, Benjamin, Lamla, Thorsten, Ciossek, Thomas, Bakker, Remko A., Redemann, Norbert H.
Publicado 2021

Identification of Broadly Applicable Adeno-Associated Virus Vectors by Systematic Comparison of Commonly Used Capsid Variants In Vitro

por Weinmann, Jonas, Söllner, Julia, Abele, Sarah, Zimmermann, Gudrun, Zuckschwerdt, Kai, Mayer, Christine, Danner-Liskus, Jenny, Peltzer, Alexander, Schuler, Michael, Lamla, Thorsten, Strobel, Benjamin
Publicado 2022

AAV-mediated expression of a new conformational anti-aggregated α-synuclein antibody prolongs survival in a genetic model of α-synucleinopathies

por Düchs, Matthias, Blazevic, Dragica, Rechtsteiner, Philipp, Kenny, Cynthia, Lamla, Thorsten, Low, Sarah, Savistchenko, Jimmy, Neumann, Manuela, Melki, Ronald, Schönberger, Tanja, Stierstorfer, Birgit, Wyatt, David, Igney, Frederik, Ciossek, Thomas
Publicado 2023

Transcriptome analysis of AAV-induced retinopathy models expressing human VEGF, TNF-α, and IL-6 in murine eyes

por Becker, Kolja, Weigelt, Carina M., Fuchs, Holger, Viollet, Coralie, Rust, Werner, Wyatt, Hannah, Huber, Jochen, Lamla, Thorsten, Fernandez-Albert, Francesc, Simon, Eric, Zippel, Nina, Bakker, Remko A., Klein, Holger, Redemann, Norbert H.
Publicado 2022

Identification of a myotropic AAV by massively parallel in vivo evaluation of barcoded capsid variants

por Weinmann, Jonas, Weis, Sabrina, Sippel, Josefine, Tulalamba, Warut, Remes, Anca, El Andari, Jihad, Herrmann, Anne-Kathrin, Pham, Quang H., Borowski, Christopher, Hille, Susanne, Schönberger, Tanja, Frey, Norbert, Lenter, Martin, VandenDriessche, Thierry, Müller, Oliver J., Chuah, Marinee K., Lamla, Thorsten, Grimm, Dirk
Publicado 2020

Human stem cell-based retina on chip as new translational model for validation of AAV retinal gene therapy vectors

por Achberger, Kevin, Cipriano, Madalena, Düchs, Matthias J., Schön, Christian, Michelfelder, Stefan, Stierstorfer, Birgit, Lamla, Thorsten, Kauschke, Stefan G., Chuchuy, Johanna, Roosz, Julia, Mesch, Lena, Cora, Virginia, Pars, Selin, Pashkovskaia, Natalia, Corti, Serena, Hartmann, Sophia-Marie, Kleger, Alexander, Kreuz, Sebastian, Maier, Udo, Liebau, Stefan, Loskill, Peter
Publicado 2021

GPR180 is a component of TGFβ signalling that promotes thermogenic adipocyte function and mediates the metabolic effects of the adipocyte-secreted factor CTHRC1

por Balazova, Lucia, Balaz, Miroslav, Horvath, Carla, Horváth, Áron, Moser, Caroline, Kovanicova, Zuzana, Ghosh, Adhideb, Ghoshdastider, Umesh, Efthymiou, Vissarion, Kiehlmann, Elke, Sun, Wenfei, Dong, Hua, Ding, Lianggong, Amri, Ez-Zoubir, Nuutila, Pirjo, Virtanen, Kirsi A., Niemi, Tarja, Ukropcova, Barbara, Ukropec, Jozef, Pelczar, Pawel, Lamla, Thorsten, Hamilton, Bradford, Neubauer, Heike, Wolfrum, Christian
Publicado 2021