Preclinical toxicity and pharmacokinetics of a new orally bioavailable flubendazole formulation and the impact for clinical trials and risk/benefit to patients

por Lachau-Durand, Sophie, Lammens, Lieve, van der Leede, Bas-jan, Van Gompel, Jacky, Bailey, Graham, Engelen, Marc, Lampo, Ann
Publicado 2019

Safety, Tolerability, and Pharmacokinetics of JNJ-1802, a Pan-serotype Dengue Direct Antiviral Small Molecule, in a Phase 1, Double-Blind, Randomized, Dose-Escalation Study in Heal...

por Ackaert, Oliver, Vanhoutte, Frédéric, Verpoorten, Nathalie, Buelens, Annemie, Lachau-Durand, Sophie, Lammens, Lieve, Hoetelmans, Richard, Van Loock, Marnix, Herrera-Taracena, Guillermo
Publicado 2023

A dynamic model of the intestinal epithelium integrates multiple sources of preclinical data and enables clinical translation of drug‐induced toxicity

por Gall, Louis, Jardi, Ferran, Lammens, Lieve, Piñero, Janet, Souza, Terezinha M., Rodrigues, Daniela, Jennen, Danyel G. J., de Kok, Theo M., Coyle, Luke, Chung, Seung‐Wook, Ferreira, Sofia, Jo, Heeseung, Beattie, Kylie A., Kelly, Colette, Duckworth, Carrie A., Pritchard, D. Mark, Pin, Carmen
Publicado 2023