Fast evolutionary rates associated with functional loss in class I glucose transporters of Schistosoma mansoni

por Cabezas-Cruz, Alejandro, Valdés, James J., Lancelot, Julien, Pierce, Raymond J.
Publicado 2015

Epigenetic control of gene function in schistosomes: a source of therapeutic targets?

por Cabezas-Cruz, Alejandro, Lancelot, Julien, Caby, Stéphanie, Oliveira, Guilherme, Pierce, Raymond J.
Publicado 2014

Compound library screening identified Akt/PKB kinase pathway inhibitors as potential key molecules for the development of new chemotherapeutics against schistosomiasis

por Morel, Marion, Vanderstraete, Mathieu, Cailliau, Katia, Lescuyer, Arlette, Lancelot, Julien, Dissous, Colette
Publicado 2014

Dual Targeting of Insulin and Venus Kinase Receptors of Schistosoma mansoni for Novel Anti-schistosome Therapy

por Vanderstraete, Mathieu, Gouignard, Nadège, Cailliau, Katia, Morel, Marion, Lancelot, Julien, Bodart, Jean-François, Dissous, Colette
Publicado 2013

Analysis of the interactome of Schistosoma mansoni histone deacetylase 8

por Caby, Stéphanie, Pagliazzo, Lucile, Lancelot, Julien, Saliou, Jean-Michel, Bertheaume, Nicolas, Pierce, Raymond J., Roger, Emmanuel
Publicado 2017

Schistosoma mansoni Sirtuins: Characterization and Potential as Chemotherapeutic Targets

por Lancelot, Julien, Caby, Stéphanie, Dubois-Abdesselem, Florence, Vanderstraete, Mathieu, Trolet, Jacques, Oliveira, Guilherme, Bracher, Franz, Jung, Manfred, Pierce, Raymond J.
Publicado 2013

Histone deacetylase 8 interacts with the GTPase SmRho1 in Schistosoma mansoni

por Pagliazzo, Lucile, Caby, Stéphanie, Lancelot, Julien, Salomé-Desnoulez, Sophie, Saliou, Jean-Michel, Heimburg, Tino, Chassat, Thierry, Cailliau, Katia, Sippl, Wolfgang, Vicogne, Jérôme, Pierce, Raymond J.
Publicado 2021

Structure‐Based Design, Synthesis, and Biological Evaluation of Triazole‐Based smHDAC8 Inhibitors

por Kalinin, Dmitrii V., Jana, Sunit K., Pfafenrot, Maxim, Chakrabarti, Alokta, Melesina, Jelena, Shaik, Tajith B., Lancelot, Julien, Pierce, Raymond J., Sippl, Wolfgang, Romier, Christophe, Jung, Manfred, Holl, Ralph
Publicado 2020

Effect of clinically approved HDAC inhibitors on Plasmodium, Leishmania and Schistosoma parasite growth

por Chua, Ming Jang, Arnold, Megan S.J., Xu, Weijun, Lancelot, Julien, Lamotte, Suzanne, Späth, Gerald F., Prina, Eric, Pierce, Raymond J., Fairlie, David P., Skinner-Adams, Tina S., Andrews, Katherine T.
Publicado 2016

A Novel Class of Schistosoma mansoni Histone Deacetylase 8 (HDAC8) Inhibitors Identified by Structure-Based Virtual Screening and In Vitro Testing

por Simoben, Conrad V., Robaa, Dina, Chakrabarti, Alokta, Schmidtkunz, Karin, Marek, Martin, Lancelot, Julien, Kannan, Srinivasaraghavan, Melesina, Jelena, Shaik, Tajith B., Pierce, Raymond J., Romier, Christophe, Jung, Manfred, Sippl, Wolfgang
Publicado 2018

Epigenetic Changes Modulate Schistosome Egg Formation and Are a Novel Target for Reducing Transmission of Schistosomiasis

por Carneiro, Vitor Coutinho, de Abreu da Silva, Isabel Caetano, Torres, Eduardo José Lopes, Caby, Stephany, Lancelot, Julien, Vanderstraete, Mathieu, Furdas, Silviya D., Jung, Manfred, Pierce, Raymond J., Fantappié, Marcelo Rosado
Publicado 2014

Structural Basis for the Inhibition of Histone Deacetylase 8 (HDAC8), a Key Epigenetic Player in the Blood Fluke Schistosoma mansoni

por Marek, Martin, Kannan, Srinivasaraghavan, Hauser, Alexander-Thomas, Moraes Mourão, Marina, Caby, Stéphanie, Cura, Vincent, Stolfa, Diana A., Schmidtkunz, Karin, Lancelot, Julien, Andrade, Luiza, Renaud, Jean-Paul, Oliveira, Guilherme, Sippl, Wolfgang, Jung, Manfred, Cavarelli, Jean, Pierce, Raymond J., Romier, Christophe
Publicado 2013

Pharmacological inhibition of lysine-specific demethylase 1 (LSD1) induces global transcriptional deregulation and ultrastructural alterations that impair viability in Schistosoma...

por Coutinho Carneiro, Vitor, de Abreu da Silva, Isabel Caetano, Amaral, Murilo Sena, Pereira, Adriana S. A., Silveira, Gilbert Oliveira, Pires, David da Silva, Verjovski-Almeida, Sergio, Dekker, Frank J., Rotili, Dante, Mai, Antonello, Lopes-Torres, Eduardo José, Robaa, Dina, Sippl, Wolfgang, Pierce, Raymond J., Borrello, M. Teresa, Ganesan, A., Lancelot, Julien, Thiengo, Silvana, Fernandez, Monica Ammon, Vicentino, Amanda Roberta Revoredo, Mourão, Marina Moraes, Coelho, Fernanda Sales, Fantappié, Marcelo Rosado
Publicado 2020