Physiologically‐based pharmacokinetic modeling to predict drug interactions of lemborexant with CYP3A inhibitors

por Ueno, Takashi, Miyajima, Yukiko, Landry, Ishani, Lalovic, Bojan, Schuck, Edgar
Publicado 2021

Population Pharmacokinetics and Exposure‐Response Analyses for the Most Frequent Adverse Events Following Treatment With Lemborexant, an Orexin Receptor Antagonist, in Subjects Wit...

por Lalovic, Bojan, Majid, Oneeb, Aluri, Jagadeesh, Landry, Ishani, Moline, Margaret, Hussein, Ziad
Publicado 2020

Effect of gastric acid‐reducing agents on the pharmacokinetics and efficacy of lemborexant

por Landry, Ishani, Aluri, Jagadeesh, Hall, Nancy, Kumar, Dinesh, Dayal, Satish, Moline, Margaret, Reyderman, Larisa
Publicado 2020

Effect of severe renal impairment on pharmacokinetics, safety, and tolerability of lemborexant

por Landry, Ishani, Aluri, Jagadeesh, Hall, Nancy, Filippov, Gleb, Dayal, Satish, Moline, Margaret, Reyderman, Larisa
Publicado 2021

Effect of hepatic impairment on pharmacokinetics, safety, and tolerability of lemborexant

por Dayal, Satish, Aluri, Jagadeesh, Hall, Nancy, Filippov, Gleb, Moline, Margaret, Reyderman, Larisa, Landry, Ishani
Publicado 2021

Effects of Lemborexant on the Pharmacokinetics of Oral Contraceptives: Results From a Phase 1 Drug‐Drug Interaction Study in Healthy Females

por Landry, Ishani, Aluri, Jagadeesh, Hall, Nancy, Filippov, Gleb, Dayal, Satish, Moline, Margaret, Reyderman, Larisa
Publicado 2021

The abuse potential of lemborexant, a dual orexin receptor antagonist, according to the 8 factors of the Controlled Substances Act

por Moline, Margaret, Asakura, Shoji, Beuckman, Carsten, Landry, Ishani, Setnik, Beatrice, Ashworth, Judy, Henningfield, Jack E.
Publicado 2023

Pharmacokinetics, Pharmacodynamics, and Safety of the Dual Orexin Receptor Antagonist Lemborexant: Findings From Single‐Dose and Multiple‐Ascending‐Dose Phase 1 Studies in Healthy...

por Landry, Ishani, Nakai, Kenya, Ferry, Jim, Aluri, Jagadeesh, Hall, Nancy, Lalovic, Bojan, Moline, Margaret L.
Publicado 2020

Effect of alcohol coadministration on the pharmacodynamics, pharmacokinetics, and safety of lemborexant: A randomized, placebo-controlled crossover study

por Landry, Ishani, Hall, Nancy, Aluri, Jagadeesh, Filippov, Gleb, Setnik, Beatrice, Dayal, Satish, Reyderman, Larisa, Moline, Margaret
Publicado 2022

Abuse Potential of Lemborexant, a Dual Orexin Receptor Antagonist, Compared With Zolpidem and Suvorexant in Recreational Sedative Users

por Landry, Ishani, Hall, Nancy, Aluri, Jagadeesh, Filippov, Gleb, Reyderman, Larisa, Setnik, Beatrice, Henningfield, Jack, Moline, Margaret
Publicado 2022

Acute Cognitive Effects of the Dual Orexin Receptor Antagonist Lemborexant Compared With Suvorexant and Zolpidem in Recreational Sedative Users

por Landry, Ishani, Hall, Nancy, Alur, Jagadeesh, Filippov, Gleb, Reyderman, Larisa, Setnik, Beatrice, Henningfield, Jack, Moline, Margaret
Publicado 2022

Population pharmacokinetic‐pharmacodynamic analyses of amyloid positron emission tomography and plasma biomarkers for lecanemab in subjects with early Alzheimer's disease

por Hayato, Seiichi, Takenaka, Osamu, Sreerama Reddy, Sree Harsha, Landry, Ishani, Reyderman, Larisa, Koyama, Akihiko, Swanson, Chad, Yasuda, Sanae, Hussein, Ziad
Publicado 2022

Evaluation of the CYP3A and CYP2B6 Drug‐Drug Interaction Potential of Lemborexant

por Landry, Ishani, Aluri, Jagadeesh, Nakai, Kenya, Hall, Nancy, Miyajima, Yukiko, Ueno, Takashi, Dayal, Satish, Filippov, Gleb, Lalovic, Bojan, Moline, Margaret, Reyderman, Larisa
Publicado 2021

ECG Evaluation as Part of the Clinical Pharmacology Strategy in the Development of New Drugs: A Review of Current Practices and Opportunities Based on Five Case Studies

por Darpo, Borje, Borin, Marie, Ferber, Georg, Galluppi, Gerald R., Hopkins, Seth C., Landry, Ishani, Lo, Arthur, Rege, Bhaskar, Reyderman, Larisa, Sun, Lei, Watanabe, Takao, Xue, Hongqi, Yasuda, Sally
Publicado 2022

On-the-road driving performance the morning after bedtime administration of lemborexant in healthy adult and elderly volunteers

por Vermeeren, Annemiek, Jongen, Stefan, Murphy, Patricia, Moline, Margaret, Filippov, Gleb, Pinner, Kate, Perdomo, Carlos, Landry, Ishani, Majid, Oneeb, Van Oers, Anita C M, Van Leeuwen, Cees J, Ramaekers, Johannes G, Vuurman, Eric F P M
Publicado 2018

Erratum to: On-the-road driving performance the morning after bedtime administration of lemborexant in healthy adult and elderly volunteers

por Vermeeren, Annemiek, Jongen, Stefan, Murphy, Patricia, Moline, Margaret, Filippov, Gleb, Pinner, Kate, Perdomo, Carlos, Landry, Ishani, Majid, Oneeb, Van Oers, Anita C M, Van Leeuwen, Cees J, Ramaekers, Johannes G, Vuurman, Eric F P M
Publicado 2020