GRKs as Key Modulators of Opioid Receptor Function

por Lemel, Laura, Lane, J Robert, Canals, Meritxell
Publicado 2020

Influence of Chemokine N-Terminal Modification on Biased Agonism at the Chemokine Receptor CCR1

por Sanchez, Julie, Lane, J. Robert, Canals, Meritxell, Stone, Martin J.
Publicado 2019

Systematic Assessment of Chemokine Signaling at Chemokine Receptors CCR4, CCR7 and CCR10

por Lim, Herman D., Lane, J. Robert, Canals, Meritxell, Stone, Martin J.
Publicado 2021

Enantioenriched Positive Allosteric Modulators Display Distinct Pharmacology at the Dopamine D(1) Receptor

por Fyfe, Tim J., Scammells, Peter J., Lane, J. Robert, Capuano, Ben
Publicado 2021

The respiratory depressant effects of mitragynine are limited by its conversion to 7‐OH mitragynine

por Hill, Rob, Kruegel, Andrew C., Javitch, Jonathan A., Lane, J. Robert, Canals, Meritxell
Publicado 2022

Reply to ‘Antipsychotics with similar association kinetics at dopamine D(2) receptors differ in extrapyramidal side-effects’

por Sykes, David A., Lane, J. Robert, Szabo, Monika, Capuano, Ben, Javitch, Jonathan A., Charlton, Steven J.
Publicado 2018

Extrapyramidal side effects of antipsychotics are linked to their association kinetics at dopamine D(2) receptors

por Sykes, David A., Moore, Holly, Stott, Lisa, Holliday, Nicholas, Javitch, Jonathan A., Lane, J. Robert, Charlton, Steven J.
Publicado 2017

The E(2.65)A mutation disrupts dynamic binding poses of SB269652 at the dopamine D2 and D3 receptors

por Verma, Ravi Kumar, Abramyan, Ara M., Michino, Mayako, Free, R. Benjamin, Sibley, David R., Javitch, Jonathan A., Lane, J. Robert, Shi, Lei
Publicado 2018

Arrestin recruitment to dopamine D2 receptor mediates locomotion but not incentive motivation

por Donthamsetti, Prashant, Gallo, Eduardo F., Buck, David C., Stahl, Edward L., Zhu, Ying, Lane, J. Robert, Bohn, Laura M., Neve, Kim A., Kellendonk, Christoph, Javitch, Jonathan A.
Publicado 2018

Distinct inactive conformations of the dopamine D2 and D3 receptors correspond to different extents of inverse agonism

por Lane, J Robert, Abramyan, Ara M, Adhikari, Pramisha, Keen, Alastair C, Lee, Kuo-Hao, Sanchez, Julie, Verma, Ravi Kumar, Lim, Herman D, Yano, Hideaki, Javitch, Jonathan A, Shi, Lei
Publicado 2020

OZITX, a pertussis toxin-like protein for occluding inhibitory G protein signalling including Gα(z)

por Keen, Alastair C., Pedersen, Maria Hauge, Lemel, Laura, Scott, Daniel J., Canals, Meritxell, Littler, Dene R., Beddoe, Travis, Ono, Yuki, Shi, Lei, Inoue, Asuka, Javitch, Jonathan A., Lane, J. Robert
Publicado 2022

A new mechanism of allostery in a G protein-coupled receptor dimer

por Lane, J. Robert, Donthamsetti, Prashant, Shonberg, Jeremy, Draper-Joyce, Christopher J., Dentry, Samuel, Michino, Mayako, Shi, Lei, López, Laura, Scammells, Peter J., Capuano, Ben, Sexton, Patrick M., Javitch, Jonathan A., Christopoulos, Arthur
Publicado 2014

The role of kinetic context in apparent biased agonism at GPCRs

por Klein Herenbrink, Carmen, Sykes, David A., Donthamsetti, Prashant, Canals, Meritxell, Coudrat, Thomas, Shonberg, Jeremy, Scammells, Peter J., Capuano, Ben, Sexton, Patrick M., Charlton, Steven J., Javitch, Jonathan A., Christopoulos, Arthur, Lane, J. Robert
Publicado 2016

β2-adrenoceptor signaling regulates invadopodia formation to enhance tumor cell invasion

por Creed, Sarah J., Le, Caroline P., Hassan, Mona, Pon, Cindy K., Albold, Sabine, Chan, Keefe T., Berginski, Matthew E., Huang, Zhendong, Bear, James E., Lane, J. Robert, Halls, Michelle L., Ferrari, Davide, Nowell, Cameron J., Sloan, Erica K.
Publicado 2015

The action of a negative allosteric modulator at the dopamine D(2) receptor is dependent upon sodium ions

por Draper-Joyce, Christopher J., Verma, Ravi Kumar, Michino, Mayako, Shonberg, Jeremy, Kopinathan, Anitha, Klein Herenbrink, Carmen, Scammells, Peter J., Capuano, Ben, Abramyan, Ara M., Thal, David M., Javitch, Jonathan A., Christopoulos, Arthur, Shi, Lei, Lane, J. Robert
Publicado 2018

Dual pancreatic adrenergic and dopaminergic signaling as a therapeutic target of bromocriptine

por Aslanoglou, Despoina, Bertera, Suzanne, Friggeri, Laura, Sánchez-Soto, Marta, Lee, Jeongkyung, Xue, Xiangning, Logan, Ryan W., Lane, J. Robert, Yechoor, Vijay K., McCormick, Peter J., Meiler, Jens, Free, R. Benjamin, Sibley, David R., Bottino, Rita, Freyberg, Zachary
Publicado 2022