Will morphing boron-based inhibitors beat the β-lactamases?

por Krajnc, Alen, Lang, Pauline A, Panduwawala, Tharindi D, Brem, Jürgen, Schofield, Christopher J
Publicado 2019

Structural Investigations of the Inhibition of Escherichia coli AmpC β-Lactamase by Diazabicyclooctanes

por Lang, Pauline A., Leissing, Thomas M., Page, Malcolm G. P., Schofield, Christopher J., Brem, Jürgen
Publicado 2021

Molecular Basis of Class A β-Lactamase Inhibition by Relebactam

por Tooke, Catherine L., Hinchliffe, Philip, Lang, Pauline A., Mulholland, Adrian J., Brem, Jürgen, Schofield, Christopher J., Spencer, James
Publicado 2019

Studies on enmetazobactam clarify mechanisms of widely used β-lactamase inhibitors

por Lang, Pauline A., Raj, Ritu, Tumber, Anthony, Lohans, Christopher T., Rabe, Patrick, Robinson, Carol V., Brem, Jürgen, Schofield, Christopher J.
Publicado 2022

Targeting the Mycobacterium tuberculosis transpeptidase Ldt(Mt2) with cysteine-reactive inhibitors including ebselen

por de Munnik, Mariska, Lohans, Christopher T., Lang, Pauline A., Langley, Gareth W., Malla, Tika R., Tumber, Anthony, Schofield, Christopher J., Brem, Jürgen
Publicado 2019

High-throughput screen with the l,d-transpeptidase Ldt(Mt2) of Mycobacterium tuberculosis reveals novel classes of covalently reacting inhibitors

por de Munnik, Mariska, Lang, Pauline A., De Dios Anton, Francisco, Cacho, Mónica, Bates, Robert H., Brem, Jürgen, Rodríguez Miquel, Beatriz, Schofield, Christopher J.
Publicado 2023

Pretargeted PET Imaging with a TCO-Conjugated Anti-CD44v6 Chimeric mAb U36 and [(89)Zr]Zr-DFO-PEG(5)-Tz

por Lumen, Dave, Vugts, Danielle, Chomet, Marion, Imlimthan, Surachet, Sarparanta, Mirkka, Vos, Ricardo, Schreurs, Maxime, Verlaan, Mariska, Lang, Pauline A., Hippeläinen, Eero, Beaino, Wissam, Windhorst, Albert D., Airaksinen, Anu J.
Publicado 2022

Bicyclic Boronates as Potent Inhibitors of AmpC, the Class C β-Lactamase from Escherichia coli

por Lang, Pauline A., Parkova, Anete, Leissing, Thomas M., Calvopiña, Karina, Cain, Ricky, Krajnc, Alen, Panduwawala, Tharindi D., Philippe, Jules, Fishwick, Colin W. G., Trapencieris, Peteris, Page, Malcolm G. P., Schofield, Christopher J., Brem, Jürgen
Publicado 2020

Bicyclic Boronate VNRX-5133 Inhibits Metallo- and Serine-β-Lactamases

por Krajnc, Alen, Brem, Jürgen, Hinchliffe, Philip, Calvopiña, Karina, Panduwawala, Tharindi D., Lang, Pauline A., Kamps, Jos J. A. G., Tyrrell, Jonathan M., Widlake, Emma, Saward, Benjamin G., Walsh, Timothy R., Spencer, James, Schofield, Christopher J.
Publicado 2019

Anaerobic fixed-target serial crystallography

por Rabe, Patrick, Beale, John H., Butryn, Agata, Aller, Pierre, Dirr, Anna, Lang, Pauline A., Axford, Danny N., Carr, Stephen B., Leissing, Thomas M., McDonough, Michael A., Davy, Bradley, Ebrahim, Ali, Orlans, Julien, Storm, Selina L. S., Orville, Allen M., Schofield, Christopher J., Owen, Robin L.
Publicado 2020

An on-demand, drop-on-drop method for studying enzyme catalysis by serial crystallography

por Butryn, Agata, Simon, Philipp S., Aller, Pierre, Hinchliffe, Philip, Massad, Ramzi N., Leen, Gabriel, Tooke, Catherine L., Bogacz, Isabel, Kim, In-Sik, Bhowmick, Asmit, Brewster, Aaron S., Devenish, Nicholas E., Brem, Jürgen, Kamps, Jos J. A. G., Lang, Pauline A., Rabe, Patrick, Axford, Danny, Beale, John H., Davy, Bradley, Ebrahim, Ali, Orlans, Julien, Storm, Selina L. S., Zhou, Tiankun, Owada, Shigeki, Tanaka, Rie, Tono, Kensuke, Evans, Gwyndaf, Owen, Robin L., Houle, Frances A., Sauter, Nicholas K., Schofield, Christopher J., Spencer, James, Yachandra, Vittal K., Yano, Junko, Kern, Jan F., Orville, Allen M.
Publicado 2021

X-ray free-electron laser studies reveal correlated motion during isopenicillin N synthase catalysis

por Rabe, Patrick, Kamps, Jos J. A. G., Sutherlin, Kyle D., Linyard, James D. S., Aller, Pierre, Pham, Cindy C., Makita, Hiroki, Clifton, Ian, McDonough, Michael A., Leissing, Thomas M., Shutin, Denis, Lang, Pauline A., Butryn, Agata, Brem, Jürgen, Gul, Sheraz, Fuller, Franklin D., Kim, In-Sik, Cheah, Mun Hon, Fransson, Thomas, Bhowmick, Asmit, Young, Iris D., O’Riordan, Lee, Brewster, Aaron S., Pettinati, Ilaria, Doyle, Margaret, Joti, Yasumasa, Owada, Shigeki, Tono, Kensuke, Batyuk, Alexander, Hunter, Mark S., Alonso-Mori, Roberto, Bergmann, Uwe, Owen, Robin L., Sauter, Nicholas K., Claridge, Timothy D. W., Robinson, Carol V., Yachandra, Vittal K., Yano, Junko, Kern, Jan F., Orville, Allen M., Schofield, Christopher J.
Publicado 2021