Utility of CSF in translational neuroscience

por de Lange, Elizabeth C. M.
Publicado 2013

Understanding Drug Delivery to the Brain Using Liposome-Based Strategies: Studies that Provide Mechanistic Insights Are Essential

por Juhairiyah, Firda, de Lange, Elizabeth C. M.
Publicado 2021

Revisiting Cerebrospinal Fluid Flow Direction and Rate in Physiologically Based Pharmacokinetic Model

por Hirasawa, Makoto, de Lange, Elizabeth C. M.
Publicado 2022

Understanding the Blood‐Brain Barrier and Beyond: Challenges and Opportunities for Novel CNS Therapeutics

por de Lange, Elizabeth C. M., Hammarlund Udenaes, Margareta
Publicado 2022

Emerging Insights for Translational Pharmacokinetic and Pharmacokinetic-Pharmacodynamic Studies: Towards Prediction of Nose-to-Brain Transport in Humans

por Ruigrok, Mitchel J. R., de Lange, Elizabeth C. M.
Publicado 2015

The need for mathematical modelling of spatial drug distribution within the brain

por Vendel, Esmée, Rottschäfer, Vivi, de Lange, Elizabeth C. M.
Publicado 2019

The 3D Brain Unit Network Model to Study Spatial Brain Drug Exposure under Healthy and Pathological Conditions

por Vendel, Esmée, Rottschäfer, Vivi, de Lange, Elizabeth C.M.
Publicado 2020

A 3D brain unit model to further improve prediction of local drug distribution within the brain

por Vendel, Esmée, Rottschäfer, Vivi, de Lange, Elizabeth C. M.
Publicado 2020

Impact of CNS Diseases on Drug Delivery to Brain Extracellular and Intracellular Target Sites in Human: A “WHAT-IF” Simulation Study

por Saleh, Mohammed A. A., de Lange, Elizabeth C. M.
Publicado 2021

Imaging Techniques in Alzheimer’s Disease: A Review of Applications in Early Diagnosis and Longitudinal Monitoring

por van Oostveen, Wieke M., de Lange, Elizabeth C. M.
Publicado 2021

Physiologically Based Modeling Approach to Predict Dopamine D2 Receptor Occupancy of Antipsychotics in Brain: Translation From Rat to Human

por Wong, Yin Cheong, Centanni, Maddalena, de Lange, Elizabeth C. M.
Publicado 2019

The impact of P-gp functionality on non-steady state relationships between CSF and brain extracellular fluid

por Westerhout, Joost, Smeets, Jean, Danhof, Meindert, de Lange, Elizabeth C. M.
Publicado 2013

The Extension of the LeiCNS-PK3.0 Model in Combination with the “Handshake” Approach to Understand Brain Tumor Pathophysiology

por Hirasawa, Makoto, Saleh, Mohammed A. A., de Lange, Elizabeth C. M.
Publicado 2022

Potential Mechanisms Underlying Resistance to Dementia in Non-Demented Individuals with Alzheimer’s Disease Neuropathology

por Kok, Frédérique K., van Leerdam, Suzanne L., de Lange, Elizabeth C.M.
Publicado 2022

Status of Metabolomic Measurement for Insights in Alzheimer’s Disease Progression—What Is Missing?

por Yin, Chunyuan, Harms, Amy C., Hankemeier, Thomas, Kindt, Alida, de Lange, Elizabeth C. M.
Publicado 2023

Drug Distribution in Brain and Cerebrospinal Fluids in Relation to IC(50) Values in Aging and Alzheimer’s Disease, Using the Physiologically Based LeiCNS-PK3.0 Model

por Saleh, Mohammed A. A., Bloemberg, Julia S., Elassaiss-Schaap, Jeroen, de Lange, Elizabeth C. M.
Publicado 2022

Revisiting atenolol as a low passive permeability marker

por Chen, Xiaomei, Slättengren, Tim, de Lange, Elizabeth C. M., Smith, David E., Hammarlund-Udenaes, Margareta
Publicado 2017

Lumbar cerebrospinal fluid-to-brain extracellular fluid surrogacy is context-specific: insights from LeiCNS-PK3.0 simulations

por Saleh, Mohammed A. A., Loo, Chi Fong, Elassaiss-Schaap, Jeroen, De Lange, Elizabeth C. M.
Publicado 2021

A New Minimal-Stress Freely-Moving Rat Model for Preclinical Studies on Intranasal Administration of CNS Drugs

por Stevens, Jasper, Suidgeest, Ernst, van der Graaf, Piet Hein, Danhof, Meindert, de Lange, Elizabeth C. M.
Publicado 2009

Alteration in P-glycoprotein Functionality Affects Intrabrain Distribution of Quinidine More Than Brain Entry—A Study in Rats Subjected to Status Epilepticus by Kainate

por Syvänen, Stina, Schenke, Maarten, van den Berg, Dirk-Jan, Voskuyl, Rob A., de Lange, Elizabeth C.
Publicado 2012