HIV-1 anchor inhibitors and membrane fusion inhibitors target distinct but overlapping steps in virus entry

por Eggink, Dirk, Bontjer, Ilja, de Taeye, Steven W., Langedijk, Johannes P. M., Berkhout, Ben, Sanders, Rogier W.
Publicado 2019

Structure-Based Design of Prefusion-Stabilized Filovirus Glycoprotein Trimers

por Rutten, Lucy, Gilman, Morgan S.A., Blokland, Sven, Juraszek, Jarek, McLellan, Jason S., Langedijk, Johannes P.M.
Publicado 2020

Correction: HIV-1 anchor inhibitors and membrane fusion inhibitors target distinct but overlapping steps in virus entry

por Eggink, Dirk, Bontjer, Ilja, de Taeye, Steven W., Langedijk, Johannes P.M., Berkhout, Ben, Sanders, Rogier W.
Publicado 2022

Transient opening of trimeric prefusion RSV F proteins

por Gilman, Morgan S. A., Furmanova-Hollenstein, Polina, Pascual, Gabriel, B. van ‘t Wout, Angélique, Langedijk, Johannes P. M., McLellan, Jason S.
Publicado 2019

Stabilizing the closed SARS-CoV-2 spike trimer

por Juraszek, Jarek, Rutten, Lucy, Blokland, Sven, Bouchier, Pascale, Voorzaat, Richard, Ritschel, Tina, Bakkers, Mark J. G., Renault, Ludovic L. R., Langedijk, Johannes P. M.
Publicado 2021

Sequential Conformational Changes in the Morbillivirus Attachment Protein Initiate the Membrane Fusion Process

por Ader-Ebert, Nadine, Khosravi, Mojtaba, Herren, Michael, Avila, Mislay, Alves, Lisa, Bringolf, Fanny, Örvell, Claes, Langedijk, Johannes P., Zurbriggen, Andreas, Plemper, Richard K., Plattet, Philippe
Publicado 2015

Adenovector 26 encoded prefusion conformation stabilized RSV-F protein induces long-lasting Th1-biased immunity in neonatal mice

por van der Fits, Leslie, Bolder, Renske, Heemskerk-van der Meer, Marjolein, Drijver, Joke, van Polanen, Yolinda, Serroyen, Jan, Langedijk, Johannes P. M., Schuitemaker, Hanneke, Saeland, Eirikur, Zahn, Roland
Publicado 2020

A highly stable prefusion RSV F vaccine derived from structural analysis of the fusion mechanism

por Krarup, Anders, Truan, Daphné, Furmanova-Hollenstein, Polina, Bogaert, Lies, Bouchier, Pascale, Bisschop, Ilona J. M., Widjojoatmodjo, Myra N., Zahn, Roland, Schuitemaker, Hanneke, McLellan, Jason S., Langedijk, Johannes P. M.
Publicado 2015

Peptide mimetics of immunoglobulin A (IgA) and FcαRI block IgA‐induced human neutrophil activation and migration

por Heineke, Marieke H., van der Steen, Lydia P.E., Korthouwer, Rianne M., Hage, J. Joris, Langedijk, Johannes P.M., Benschop, Joris J., Bakema, Jantine E., Slootstra, Jerry W., van Egmond, Marjolein
Publicado 2017

Universal stabilization of the influenza hemagglutinin by structure-based redesign of the pH switch regions

por Milder, Fin J., Jongeneelen, Mandy, Ritschel, Tina, Bouchier, Pascale, Bisschop, Ilona J. M., de Man, Martijn, Veldman, Daniel, Le, Lam, Kaufmann, Baerbel, Bakkers, Mark J. G., Juraszek, Jarek, Brandenburg, Boerries, Langedijk, Johannes P. M.
Publicado 2022

Structural basis for recognition of the central conserved region of RSV G by neutralizing human antibodies

por Jones, Harrison G., Ritschel, Tina, Pascual, Gabriel, Brakenhoff, Just P. J., Keogh, Elissa, Furmanova-Hollenstein, Polina, Lanckacker, Ellen, Wadia, Jehangir S., Gilman, Morgan S. A., Williamson, R. Anthony, Roymans, Dirk, van ‘t Wout, Angélique B., Langedijk, Johannes P., McLellan, Jason S.
Publicado 2018

Combination Ad26.RSV.preF/preF protein vaccine induces superior protective immunity compared with individual vaccine components in preclinical models

por Saeland, Eirikur, van der Fits, Leslie, Bolder, Renske, Heemskerk-van der Meer, Marjolein, Drijver, Joke, van Polanen, Yolinda, Vaneman, Cornelis, Tettero, Lisanne, Cox, Freek, Serroyen, Jan, Jorgensen, Matthew J., Langedijk, Johannes P. M., Schuitemaker, Hanneke, Callendret, Benoit, Zahn, Roland C.
Publicado 2023

Convergence of immune escape strategies highlights plasticity of SARS-CoV-2 spike

por Yu, Xiaodi, Juraszek, Jarek, Rutten, Lucy, Bakkers, Mark J. G., Blokland, Sven, Melchers, Jelle M., van den Broek, Niels J. F., Verwilligen, Annemiek Y. W., Abeywickrema, Pravien, Vingerhoets, Johan, Neefs, Jean-Marc, Bakhash, Shah A. Mohamed, Roychoudhury, Pavitra, Greninger, Alex, Sharma, Sujata, Langedijk, Johannes P. M.
Publicado 2023

Enhancing breadth and durability of humoral immune responses in non-human primates with an adjuvanted group 1 influenza hemagglutinin stem antigen

por Swart, Maarten, Kuipers, Harmjan, Milder, Fin, Jongeneelen, Mandy, Ritschel, Tina, Tolboom, Jeroen, Muchene, Leacky, van der Lubbe, Joan, Izquierdo Gil, Ana, Veldman, Daniel, Huizingh, Jeroen, Verspuij, Johan, Schmit-Tillemans, Sonja, Blokland, Sven, de Man, Martijn, Roozendaal, Ramon, Fox, Christopher B., Schuitemaker, Hanneke, Capelle, Martinus, Langedijk, Johannes P. M., Zahn, Roland, Brandenburg, Boerries
Publicado 2023

Therapeutic efficacy of a respiratory syncytial virus fusion inhibitor

por Roymans, Dirk, Alnajjar, Sarhad S, Battles, Michael B, Sitthicharoenchai, Panchan, Furmanova-Hollenstein, Polina, Rigaux, Peter, Berg, Joke Van den, Kwanten, Leen, Ginderen, Marcia Van, Verheyen, Nick, Vranckx, Luc, Jaensch, Steffen, Arnoult, Eric, Voorzaat, Richard, Gallup, Jack M., Larios-Mora, Alejandro, Crabbe, Marjolein, Huntjens, Dymphy, Raboisson, Pierre, Langedijk, Johannes P., Ackermann, Mark R., McLellan, Jason S, Vendeville, Sandrine, Koul, Anil
Publicado 2017

Safety and immunogenicity of two heterologous HIV vaccine regimens in healthy, HIV-uninfected adults (TRAVERSE): a randomised, parallel-group, placebo-controlled, double-blind, pha...

por Baden, Lindsey R, Stieh, Daniel J, Sarnecki, Michal, Walsh, Stephen R, Tomaras, Georgia D, Kublin, James G, McElrath, M Juliana, Alter, Galit, Ferrari, Guido, Montefiori, David, Mann, Philipp, Nijs, Steven, Callewaert, Katleen, Goepfert, Paul, Edupuganti, Srilatha, Karita, Etienne, Langedijk, Johannes P, Wegmann, Frank, Corey, Lawrence, Pau, Maria G, Barouch, Dan H, Schuitemaker, Hanneke, Tomaka, Frank
Publicado 2020

Analysis of Memory B Cell Responses and Isolation of Novel Monoclonal Antibodies with Neutralizing Breadth from HIV-1-Infected Individuals

por Corti, Davide, Langedijk, Johannes P. M., Hinz, Andreas, Seaman, Michael S., Vanzetta, Fabrizia, Fernandez-Rodriguez, Blanca M., Silacci, Chiara, Pinna, Debora, Jarrossay, David, Balla-Jhagjhoorsingh, Sunita, Willems, Betty, Zekveld, Maria J., Dreja, Hanna, O'Sullivan, Eithne, Pade, Corinna, Orkin, Chloe, Jeffs, Simon A., Montefiori, David C., Davis, David, Weissenhorn, Winfried, McKnight, Áine, Heeney, Jonathan L., Sallusto, Federica, Sattentau, Quentin J., Weiss, Robin A., Lanzavecchia, Antonio
Publicado 2010

A gp41 MPER-specific Llama VHH Requires a Hydrophobic CDR3 for Neutralization but not for Antigen Recognition

por Lutje Hulsik, David, Liu, Ying-ying, Strokappe, Nika M., Battella, Simone, El Khattabi, Mohamed, McCoy, Laura E., Sabin, Charles, Hinz, Andreas, Hock, Miriam, Macheboeuf, Pauline, Bonvin, Alexandre M. J. J., Langedijk, Johannes P. M., Davis, David, Forsman Quigley, Anna, Aasa-Chapman, Marlén M. I., Seaman, Michael S., Ramos, Alejandra, Poignard, Pascal, Favier, Adrien, Simorre, Jean-Pierre, Weiss, Robin A., Verrips, C. Theo, Weissenhorn, Winfried, Rutten, Lucy
Publicado 2013

Ad26 vector-based COVID-19 vaccine encoding a prefusion-stabilized SARS-CoV-2 Spike immunogen induces potent humoral and cellular immune responses

por Bos, Rinke, Rutten, Lucy, van der Lubbe, Joan E. M., Bakkers, Mark J. G., Hardenberg, Gijs, Wegmann, Frank, Zuijdgeest, David, de Wilde, Adriaan H., Koornneef, Annemart, Verwilligen, Annemiek, van Manen, Danielle, Kwaks, Ted, Vogels, Ronald, Dalebout, Tim J., Myeni, Sebenzile K., Kikkert, Marjolein, Snijder, Eric J., Li, Zhenfeng, Barouch, Dan H., Vellinga, Jort, Langedijk, Johannes P. M., Zahn, Roland C., Custers, Jerome, Schuitemaker, Hanneke
Publicado 2020

Ad26.COV2.S protects Syrian hamsters against G614 spike variant SARS-CoV-2 and does not enhance respiratory disease

por van der Lubbe, Joan E. M., Rosendahl Huber, Sietske K., Vijayan, Aneesh, Dekking, Liesbeth, van Huizen, Ella, Vreugdenhil, Jessica, Choi, Ying, Baert, Miranda R. M., Feddes-de Boer, Karin, Izquierdo Gil, Ana, van Heerden, Marjolein, Dalebout, Tim J., Myeni, Sebenzile K., Kikkert, Marjolein, Snijder, Eric J., de Waal, Leon, Stittelaar, Koert J., Tolboom, Jeroen T. B. M., Serroyen, Jan, Muchene, Leacky, van der Fits, Leslie, Rutten, Lucy, Langedijk, Johannes P. M., Barouch, Dan H., Schuitemaker, Hanneke, Zahn, Roland C., Wegmann, Frank
Publicado 2021