Multiomics data integration to reveal chromatin remodeling and reorganization induced by gene mutational synergy

por Yun, Haiyang, Vohra, Shabana, Lara-Astiaso, David, Huntly, Brian J.P.
Publicado 2022

Genome-wide analysis of the H3K27me3 epigenome and transcriptome in Brassica rapa

por Payá-Milans, Miriam, Poza-Viejo, Laura, Martín-Uriz, Patxi San, Lara-Astiaso, David, Wilkinson, Mark D, Crevillén, Pedro
Publicado 2019

Complement anaphylatoxins C3a and C5a induce a failing regenerative program in cardiac resident cells. Evidence of a role for cardiac resident stem cells other than cardiomyocyte r...

por Lara-Astiaso, David, Izarra, Alberto, Estrada, Juan Camilo, Albo, Carmen, Moscoso, Isabel, Samper, Enrique, Moncayo, Javier, Solano, Abelardo, Bernad, Antonio, Díez-Juan, Antonio
Publicado 2012

Early metazoan cell type diversity and the evolution of multicellular gene regulation

por Sebé-Pedrós, Arnau, Chomsky, Elad, Pang, Kevin, Lara-Astiaso, David, Gaiti, Federico, Mukamel, Zohar, Amit, Ido, Hejnol, Andreas, Degnan, Bernard M., Tanay, Amos
Publicado 2018

Characterization of freshly isolated bone marrow mesenchymal stromal cells from healthy donors and patients with multiple myeloma: transcriptional modulation of the microenvironmen...

por Alameda, Daniel, Saez, Borja, Lara-Astiaso, David, Sarvide, Sarai, Lasa, Marta, Alignani, Diego, Rodriguez, Idoia, Garate, Sonia, Vilas, Amaia, Paiva, Bruno, Alfonso-Olmos, Matias, de Espinosa, Jose Maria Lamo, Prosper, Felipe, Miguel, Jesus F. San, Maiso, Patricia
Publicado 2020

Functional and transcriptomic analysis of extracellular vesicles identifies calprotectin as a new prognostic marker in peripheral arterial disease (PAD)

por Saenz-Pipaon, Goren, San Martín, Patxi, Planell, Núria, Maillo, Alberto, Ravassa, Susana, Vilas-Zornoza, Amaia, Martinez-Aguilar, Esther, Rodriguez, José Antonio, Alameda, Daniel, Lara-Astiaso, David, Prosper, Felipe, Paramo, José Antonio, Orbe, Josune, Gomez-Cabrero, David, Roncal, Carmen
Publicado 2020

CRISPR/Cas9-mediated glycolate oxidase disruption is an efficacious and safe treatment for primary hyperoxaluria type I

por Zabaleta, Nerea, Barberia, Miren, Martin-Higueras, Cristina, Zapata-Linares, Natalia, Betancor, Isabel, Rodriguez, Saray, Martinez-Turrillas, Rebeca, Torella, Laura, Vales, Africa, Olagüe, Cristina, Vilas-Zornoza, Amaia, Castro-Labrador, Laura, Lara-Astiaso, David, Prosper, Felipe, Salido, Eduardo, Gonzalez-Aseguinolaza, Gloria, Rodriguez-Madoz, Juan R.
Publicado 2018

The phospholipid transporter PITPNC1 links KRAS to MYC to prevent autophagy in lung and pancreatic cancer

por Entrialgo-Cadierno, Rodrigo, Cueto-Ureña, Cristina, Welch, Connor, Feliu, Iker, Macaya, Irati, Vera, Laura, Morales, Xabier, Michelina, Sandra Vietti, Scaparone, Pietro, Lopez, Ines, Darbo, Elodie, Erice, Oihane, Vallejo, Adrian, Moreno, Haritz, Goñi-Salaverri, Ainhoa, Lara-Astiaso, David, Halberg, Nils, Cortes-Dominguez, Ivan, Guruceaga, Elizabeth, Ambrogio, Chiara, Lecanda, Fernando, Vicent, Silve
Publicado 2023

Correction: The phospholipid transporter PITPNC1 links KRAS to MYC to prevent autophagy in lung and pancreatic cancer

por Entrialgo‑Cadierno, Rodrigo, Cueto‑Ureña, Cristina, Welch, Connor, Feliu, Iker, Macaya, Irati, Vera, Laura, Morales, Xabier, Michelina, Sandra Vietti, Scaparone, Pietro, Lopez, Ines, Darbo, Elodie, Erice, Oihane, Vallejo, Adrian, Moreno, Haritz, Goñi‑Salaverri, Ainhoa, Lara‑Astiaso, David, Halberg, Nils, Cortes‑Dominguez, Ivan, Guruceaga, Elizabeth, Ambrogio, Chiara, Lecanda, Fernando, Vicent, Silve
Publicado 2023

Mutational synergy during leukemia induction remodels chromatin accessibility, modification and 3-Dimensional DNA topology to alter gene expression

por Yun, Haiyang, Narayan, Nisha, Vohra, Shabana, Giotopoulos, George, Mupo, Annalisa, Madrigal, Pedro, Sasca, Daniel, Lara-Astiaso, David, Horton, Sarah J., Agrawal-Singh, Shuchi, Meduri, Eshwar, Basheer, Faisal, Marando, Ludovica, Gozdecka, Malgorzata, Dovey, Oliver M., Castillo-Venzor, Aracely, Wang, Xiaonan, Gallipoli, Paolo, Müller-Tidow, Carsten, Osborne, Cameron S., Vassiliou, George S., Huntly, Brian J. P.
Publicado 2021

In vivo screening characterizes chromatin factor functions during normal and malignant hematopoiesis

por Lara-Astiaso, David, Goñi-Salaverri, Ainhoa, Mendieta-Esteban, Julen, Narayan, Nisha, Del Valle, Cynthia, Gross, Torsten, Giotopoulos, George, Beinortas, Tumas, Navarro-Alonso, Mar, Aguado-Alvaro, Laura Pilar, Zazpe, Jon, Marchese, Francesco, Torrea, Natalia, Calvo, Isabel A., Lopez, Cecile K., Alignani, Diego, Lopez, Aitziber, Saez, Borja, Taylor-King, Jake P., Prosper, Felipe, Fortelny, Nikolaus, Huntly, Brian J. P.
Publicado 2023

Signature-driven repurposing of Midostaurin for combination with MEK1/2 and KRASG12C inhibitors in lung cancer

por Macaya, Irati, Roman, Marta, Welch, Connor, Entrialgo-Cadierno, Rodrigo, Salmon, Marina, Santos, Alba, Feliu, Iker, Kovalski, Joanna, Lopez, Ines, Rodriguez-Remirez, Maria, Palomino-Echeverria, Sara, Lonfgren, Shane M., Ferrero, Macarena, Calabuig, Silvia, Ludwig, Iziar A., Lara-Astiaso, David, Jantus-Lewintre, Eloisa, Guruceaga, Elizabeth, Narayanan, Shruthi, Ponz-Sarvise, Mariano, Pineda-Lucena, Antonio, Lecanda, Fernando, Ruggero, Davide, Khatri, Purvesh, Santamaria, Enrique, Fernandez-Irigoyen, Joaquin, Ferrer, Irene, Paz-Ares, Luis, Drosten, Matthias, Barbacid, Mariano, Gil-Bazo, Ignacio, Vicent, Silve
Publicado 2023

The transcription factor DDIT3 is a potential driver of dyserythropoiesis in myelodysplastic syndromes

por Berastegui, Nerea, Ainciburu, Marina, Romero, Juan P., Garcia-Olloqui, Paula, Alfonso-Pierola, Ana, Philippe, Céline, Vilas-Zornoza, Amaia, San Martin-Uriz, Patxi, Ruiz-Hernández, Raquel, Abarrategi, Ander, Ordoñez, Raquel, Alignani, Diego, Sarvide, Sarai, Castro-Labrador, Laura, Lamo-Espinosa, José M., San-Julian, Mikel, Jimenez, Tamara, López-Cadenas, Félix, Muntion, Sandra, Sanchez-Guijo, Fermin, Molero, Antonieta, Montoro, Maria Julia, Tazón, Bárbara, Serrano, Guillermo, Diaz-Mazkiaran, Aintzane, Hernaez, Mikel, Huerga, Sofía, Bewicke-Copley, Findlay, Rio-Machin, Ana, Maurano, Matthew T., Díez-Campelo, María, Valcarcel, David, Rouault-Pierre, Kevin, Lara-Astiaso, David, Ezponda, Teresa, Prosper, Felipe
Publicado 2022

Chromatin activation as a unifying principle underlying pathogenic mechanisms in multiple myeloma

por Ordoñez, Raquel, Kulis, Marta, Russiñol, Nuria, Chapaprieta, Vicente, Carrasco-Leon, Arantxa, García-Torre, Beatriz, Charalampopoulou, Stella, Clot, Guillem, Beekman, Renée, Meydan, Cem, Duran-Ferrer, Martí, Verdaguer-Dot, Núria, Vilarrasa-Blasi, Roser, Soler-Vila, Paula, Garate, Leire, Miranda, Estíbaliz, San José-Enériz, Edurne, Rodriguez-Madoz, Juan R., Ezponda, Teresa, Martínez-Turrilas, Rebeca, Vilas-Zornoza, Amaia, Lara-Astiaso, David, Dupéré-Richer, Daphné, Martens, Joost H.A., El-Omri, Halima, Taha, Ruba Y., Calasanz, Maria J., Paiva, Bruno, San Miguel, Jesus, Flicek, Paul, Gut, Ivo, Melnick, Ari, Mitsiades, Constantine S., Licht, Jonathan D., Campo, Elias, Stunnenberg, Hendrik G., Agirre, Xabier, Prosper, Felipe, Martin-Subero, Jose I.
Publicado 2020