Tumour necrosis factor signalling in health and disease

por Holbrook, Jonathan, Lara-Reyna, Samuel, Jarosz-Griffiths, Heledd, McDermott, Michael F.
Publicado 2019

Dysregulated signalling pathways in innate immune cells with cystic fibrosis mutations

por Lara-Reyna, Samuel, Holbrook, Jonathan, Jarosz-Griffiths, Heledd H., Peckham, Daniel, McDermott, Michael F.
Publicado 2020

Inflammasome activation: from molecular mechanisms to autoinflammation

por Lara‐Reyna, Samuel, Caseley, Emily A, Topping, Joanne, Rodrigues, François, Jimenez Macias, Jorge, Lawler, Sean E, McDermott, Michael F
Publicado 2022

Species- and strain-specific differences in the phagocytosis of Prototheca: insights from live-cell imaging

por Haider, Mohammed J. A., Shave, Christopher D., Onyishi, Chinaemerem U., Jagielski, Tomasz, Lara-Reyna, Samuel, Frickel, Eva-Maria, May, Robin C.
Publicado 2023

Identification of Critical Transcriptomic Signaling Pathways in Patients with H Syndrome and Rosai-Dorfman Disease

por Lara-Reyna, Samuel, Poulter, James A., Vasconcelos, Elton J.R., Kacar, Mark, McDermott, Michael F., Tooze, Reuben, Doffinger, Rainer, Savic, Sinisa
Publicado 2020

Metabolic Reprograming of Cystic Fibrosis Macrophages via the IRE1α Arm of the Unfolded Protein Response Results in Exacerbated Inflammation

por Lara-Reyna, Samuel, Scambler, Thomas, Holbrook, Jonathan, Wong, Chi, Jarosz-Griffiths, Heledd H., Martinon, Fabio, Savic, Sinisa, Peckham, Daniel, McDermott, Michael F.
Publicado 2019

Evidence of B Cell Clonality and Investigation Into Properties of the IgM in Patients With Schnitzler Syndrome

por Pathak, Shelly, Rowczenio, Dorota, Lara-Reyna, Samuel, Kacar, Mark, Owen, Roger, Doody, Gina, Krause, Karoline, Lachmann, Helen, Doffinger, Rainer, Newton, Darren, Savic, Sinisa
Publicado 2020

An Atypical Autoinflammatory Disease Due to an LRR Domain NLRP3 Mutation Enhancing Binding to NEK7

por Caseley, Emily A., Lara-Reyna, Samuel, Poulter, James A., Topping, Joanne, Carter, Clive, Nadat, Fatima, Spickett, Gavin P., Savic, Sinisa, McDermott, Michael F.
Publicado 2021

ENaC-mediated sodium influx exacerbates NLRP3-dependent inflammation in cystic fibrosis

por Scambler, Thomas, Jarosz-Griffiths, Heledd H, Lara-Reyna, Samuel, Pathak, Shelly, Wong, Chi, Holbrook, Jonathan, Martinon, Fabio, Savic, Sinisa, Peckham, Daniel, McDermott, Michael F
Publicado 2019

Neurodegenerative Disease and the NLRP3 Inflammasome

por Holbrook, Jonathan A., Jarosz-Griffiths, Heledd H., Caseley, Emily, Lara-Reyna, Samuel, Poulter, James A., Williams-Gray, Caroline H., Peckham, Daniel, McDermott, Michael F.
Publicado 2021

Toll-like receptor 4 and macrophage scavenger receptor 1 crosstalk regulates phagocytosis of a fungal pathogen

por Onyishi, Chinaemerem U., Desanti, Guillaume E., Wilkinson, Alex L., Lara-Reyna, Samuel, Frickel, Eva-Maria, Fejer, Gyorgy, Christophe, Olivier D., Bryant, Clare E., Mukhopadhyay, Subhankar, Gordon, Siamon, May, Robin C.
Publicado 2023

Dexamethasone impairs the expression of antimicrobial mediators in lipopolysaccharide-activated primary macrophages by inhibiting both expression and function of interferon β

por O’Neil, John D., Bolimowska, Oliwia O., Clayton, Sally A., Tang, Tina, Daley, Kalbinder K., Lara-Reyna, Samuel, Warner, Jordan, Martin, Claire S., Mahida, Rahul Y., Hardy, Rowan S., Arthur, J. Simon C., Clark, Andrew R.
Publicado 2023

Different CFTR modulator combinations downregulate inflammation differently in cystic fibrosis

por Jarosz-Griffiths, Heledd H, Scambler, Thomas, Wong, Chi H, Lara-Reyna, Samuel, Holbrook, Jonathan, Martinon, Fabio, Savic, Sinisa, Whitaker, Paul, Etherington, Christine, Spoletini, Giulia, Clifton, Ian, Mehta, Anil, McDermott, Michael F, Peckham, Daniel
Publicado 2020

PIM1 controls GBP1 activity to limit self-damage and to guard against pathogen infection

por Fisch, Daniel, Pfleiderer, Moritz M, Anastasakou, Eleni, Mackie, Gillian M, Wendt, Fabian, Liu, Xiangyang, Clough, Barbara, Lara-Reyna, Samuel, Encheva, Vesela, Snijders, Ambrosius P, Bando, Hironori, Yamamoto, Masahiro, Beggs, Andrew D, Mercer, Jason, Shenoy, Avinash R, Wollscheid, Bernd, Maslowski, Kendle M, Galej, Wojtek P, Frickel, Eva-Maria
Publicado 2023

Depletion of WFS1 compromises mitochondrial function in hiPSC-derived neuronal models of Wolfram syndrome

por Zatyka, Malgorzata, Rosenstock, Tatiana R., Sun, Congxin, Palhegyi, Adina M., Hughes, Georgina W., Lara-Reyna, Samuel, Astuti, Dewi, di Maio, Alessandro, Sciauvaud, Axel, Korsgen, Miriam E., Stanulovic, Vesna, Kocak, Gamze, Rak, Malgorzata, Pourtoy-Brasselet, Sandra, Winter, Katherine, Varga, Thiago, Jarrige, Margot, Polvèche, Hélène, Correia, Joao, Frickel, Eva-Maria, Hoogenkamp, Maarten, Ward, Douglas G., Aubry, Laetitia, Barrett, Timothy, Sarkar, Sovan
Publicado 2023