A Polyaminobiaryl-Based β-secretase Modulator Alleviates Cognitive Impairments, Amyloid Load, Astrogliosis, and Neuroinflammation in APP(Swe)/PSEN1(ΔE9) Mice Model of Amyloid Patho...

por Tautou, Marie, Descamps, Florian, Larchanché, Paul-Emmanuel, Buée, Luc, El Bakali, Jamal, Melnyk, Patricia, Sergeant, Nicolas
Publicado 2023

Discovery of Compounds That Selectively Repress the Amyloidogenic Processing of the Amyloid Precursor Protein: Design, Synthesis and Pharmacological Evaluation of Diphenylpyrazoles

por Mesangeau, Christophe, Carato, Pascal, Renault, Nicolas, Coevoet, Mathilde, Larchanché, Paul-Emmanuel, Barczyk, Amélie, Buée, Luc, Sergeant, Nicolas, Melnyk, Patricia
Publicado 2022

A ß-Secretase Modulator Decreases Tau Pathology and Preserves Short-Term Memory in a Mouse Model of Neurofibrillary Degeneration

por Tautou, Marie, Eddarkaoui, Sabiha, Descamps, Florian, Larchanché, Paul-Emmanuel, El Bakali, Jamal, Goveas, Liesel Mary, Dumoulin, Mélanie, Lamarre, Chloé, Blum, David, Buée, Luc, Melnyk, Patricia, Sergeant, Nicolas
Publicado 2021